acute tubular necrosis

出典: meddic

急性尿細管壊死 ATN

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/12/16 19:08:55」(JST)

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  • Lumican overexpression exacerbates lipopolysaccharide-induced renal injury in mice.
  • Lu XM1, Ma L1, Jin YN1, Yu YQ1.
  • Molecular medicine reports.Mol Med Rep.2015 Sep;12(3):4089-94. doi: 10.3892/mmr.2015.3940. Epub 2015 Jun 16.
  • The present study aimed to investigate the role of lumican in mice with endotoxin-induced acute renal failure (ARF). Lumican transgenic mice and wild‑type mice were injected with lipopolysaccharide (LPS; 10 mg/kg) to establish a model of ARF. The mice were sacrificed at 24 h and the blood and re
  • PMID 26081832
  • Human Endothelial Colony-Forming Cells Protect against Acute Kidney Injury: Role of Exosomes.
  • Burger D1, Viñas JL1, Akbari S1, Dehak H1, Knoll W1, Gutsol A1, Carter A1, Touyz RM2, Allan DS3, Burns KD4.
  • The American journal of pathology.Am J Pathol.2015 Aug;185(8):2309-23. doi: 10.1016/j.ajpath.2015.04.010. Epub 2015 Jun 12.
  • The administration of certain progenitor cells is protective in experimental acute kidney injury (AKI), and mechanisms may involve the release of paracrine factors. Endothelial colony-forming cells (ECFCs) are endothelial precursor cells with a high proliferative capacity and pro-angiogenic potentia
  • PMID 26073035
  • Transient and Persistent Acute Kidney Injury and the Risk of Hospital Mortality in Critically Ill Patients: Results of a Multicenter Cohort Study.
  • Perinel S1, Vincent F, Lautrette A, Dellamonica J, Mariat C, Zeni F, Cohen Y, Tardy B, Souweine B, Darmon M.
  • Critical care medicine.Crit Care Med.2015 Aug;43(8):e269-75. doi: 10.1097/CCM.0000000000001077.
  • OBJECTIVE: To assess the prognostic impact of transient and persistent acute kidney injury in critically ill patients.DESIGN: Retrospective analysis of prospectively collected patient dataSETTING: : Six hospital ICUs.PATIENTS: Critically-ill patients with ICU stay longer than three days.INTERVENTION
  • PMID 25962084



Promptly treating conditions that can lead to decreased blood flow as well as decreased oxygen to the kidneys can reduce the risk of acute tubular necrosis. Blood transfusions are crossmatched to reduce the risk of ...
Acute tubular necrosis (ATN) is the most common cause of acute kidney injury (AKI) in the renal category. AKI is commonly defined as an abrupt decline in renal function, manifested by acute elevation in plasma blood ...



リンク元急性尿細管壊死」「acute kidney tubular necrosis
拡張検索nephrotoxic acute tubular necrosis


  [★] 急性腎尿細管壊死



acute tubular necrosis ATN
急性腎尿細管壊死 acute kidney tubular necrosis
[show details]

see also BPT.565


  • 臨床病理的な病態概念であり、臨床的には腎機能低下、病理的には尿細管上皮細胞の障害により形態学的に特徴づけられる。(BPT.564)
  • 急性尿細管壊死は急性腎不全の最も一般的な原因である。(BPT.564)
  • ちなみに急性腎不全をきたす他の疾患には以下のような者がある。
1. 高度の糸球体病変(RPGNなど)
2. びまん性の腎血管疾患(顕微鏡的多発血管炎、血栓性微小血管症)
3. 急性腎盂腎炎に関連した急性乳頭壊死
4. 急性薬物誘発性間質性腎炎
5. びまん性皮質壊死


大きく虚血(ischemic ATN)と毒物(nephrotoxic ATN)に分けられる。


  • 急性腎不全の症状:乏尿、尿毒症、

acute kidney tubular necrosis」



acute tubular necrosis

nephrotoxic acute tubular necrosis」

  [★] 腎毒性急性尿細管壊死



  • adj.
  • (疾患)急性の、急性型の、急性的な。(形状が)鋭い、鋭角の。(感覚、才知などが)鋭い。明敏な、鋭い眼識のある。

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「of critical importance and consequence; "an acute (or critical) lack of research funds"」

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「(先の)『鋭い』,とがった / (痛み・感情などが)『激しい』,強い / (知力・感覚などが)『鋭い』,鋭敏な / (事態が)重大な / (病気が)急性の / (音が)高い,鋭い / 鋭角の」

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「having or demonstrating ability to recognize or draw fine distinctions; "an acute observer of politics and politicians"; "incisive comments"; "icy knifelike reasoning"; "as sharp and incisive as the stroke of a fang"; "penetrating insight"; "frequent penetrative observations"」
discriminating, incisive, keen, knifelike, penetrating, penetrative, piercing, sharp

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「extremely sharp or intense; "acute pain"; "felt acute annoyance"; "intense itching and burning"」

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「having or experiencing a rapid onset and short but severe course; "acute appendicitis"; "the acute phase of the illness"; "acute patients"」

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「of an angle; less than 90 degrees」



  • adj.
  • 尿細管の、細尿管の、管状の
canalicularkidney tubulerenal tubularrenal tubuletrachearytubuleuriniferous tubule

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「constituting a tube; having hollow tubes (as for the passage of fluids)」
cannular, tubelike, tube-shaped, vasiform

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  [★] 壊死

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「the localized death of living cells (as from infection or the interruption of blood supply)」
mortification, gangrene, sphacelus

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