WordNet

of critical importance and consequence; "an acute (or critical) lack of research funds"
having or demonstrating ability to recognize or draw fine distinctions; "an acute observer of politics and politicians"; "incisive comments"; "icy knifelike reasoning"; "as sharp and incisive as the stroke of a fang"; "penetrating insight"; "frequent penetrative observations" (同)discriminating, incisive, keen, knifelike, penetrating, penetrative, piercing, sharp
extremely sharp or intense; "acute pain"; "felt acute annoyance"; "intense itching and burning" (同)intense
having or experiencing a rapid onset and short but severe course; "acute appendicitis"; "the acute phase of the illness"; "acute patients"
of an angle; less than 90 degrees
malignant neoplasm of blood-forming tissues; characterized by abnormal proliferation of leukocytes; one of the four major types of cancer (同)leukaemia, leucaemia, cancer of the blood

PrepTutorEJDIC

(先の)『鋭い』,とがった / (痛み・感情などが)『激しい』,強い / (知力・感覚などが)『鋭い』,鋭敏な / (事態が)重大な / (病気が)急性の / (音が)高い,鋭い / 鋭角の
白血病

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/05/06 01:19:24」(JST)

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Acute myelomonocytic leukemia (AMMoL) is a form of acute myeloid leukemia that involves a proliferation of CFU-GM myeloblasts and monoblasts.

It is classified under "M4" in the French-American-British classification (FAB).^[1]

It is classified under "AML, not otherwise classified" in the WHO classification.^[2]

Translocations have been observed.^[3]

Progression from myelodysplastic syndrome has been reported.^[4]

Acute myeloblastic leukemia (AML) is a group of malignant bone marrow neoplasms of myeloid precursors of white blood cells. Acute myelomonocytic leukemia (AML-M4) is a common type of pediatric AML. However, the condition is rare and represents approximately 3 % of all leukemias during childhood and has an incidence of 1.1 – 1.7 per million per year. The symptoms may be aspecific: asthenia, pallor, fever, dizziness and respiratory symptoms. More specific symptoms are bruises and/or (excessive)bleeding, coagulation disorders (DIC), neurological disorders and gingival hyperplasia. Diagnosticmethods include blood analysis, bone marrow aspirate for cytochemical, immunological and cytogeneticalanalysis, and cerebrospinal fluid (CSF) investigations. A characteristic chromosomal abnormalityobserved in AML-M4 is inv(16). Treatment includes intensive multidrug chemotherapy and in selected cases allogeneic bone marrow transplantation. Nevertheless, outcome of AML remains poor with an overall survival of 35-60%. Children with AML-M4 carrying the inv(16) abnormality have a better prognosis (61% 5-year overall survival). New therapeutics are required to increase the probability of cure in this serious disorder.

References

^ "Acute Myeloid Leukemia - Signs and Symptoms".
^ "eMedicine - Acute Myelogenous Leukemia : Article by Karen Seiter".
^ Yamamoto K, Nagata K, Tsurukubo Y; et al. (2002). "Translocation (8;12)(q13;p13) during disease progression in acute myelomonocytic leukemia with t(11;19)(q23;p13.1)". Cancer Genet. Cytogenet. 137 (1): 64–7. doi:10.1016/S0165-4608(02)00555-1. PMID 12377416.
^ Zhang L, Alsabeh R, Mecucci C; et al. (2007). "Rare t(1;11)(q23;p15) in therapy-related myelodysplastic syndrome evolving into acute myelomonocytic leukemia: a case report and review of the literature". Cancer Genet. Cytogenet. 178 (1): 42–8. doi:10.1016/j.cancergencyto.2007.06.012. PMID 17889707.

External links

Overview at Marist College
Histology at University of Virginia
Images at Nagoya University

UpToDate Contents

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1. 急性骨髄性白血病の分類 classification of acute myeloid leukemia
2. 急性骨髄性白血病の臨床症状、病理学的特徴、および診断 clinical manifestations pathologic features and diagnosis of acute myeloid leukemia
3. 高齢者における急性骨髄性白血病の治療前評価および予後 pretreatment evaluation and prognosis of acute myeloid leukemia in older adults
4. 若年成人における急性骨髄性白血病に対する導入療法 induction therapy for acute myeloid leukemia in younger adults
5. 急性骨髄性白血病における細胞遺伝学 cytogenetics in acute myeloid leukemia

English Journal

Human NUP98-IQCG fusion protein induces acute myelomonocytic leukemia in mice by dysregulating the Hox/Pbx3 pathway.

Pan MM1, Zhang QY1,2, Wang YY1, Liu P1, Ren RB1, Huang JY1, Chen LT1, Xi XD1, Chen Z1,2, Chen SJ1,2.
Leukemia.Leukemia.2016 Jul;30(7):1590-3. doi: 10.1038/leu.2015.347. Epub 2015 Dec 17.
PMID 26675333

Chronic myelomonocytic leukemia mimicking hematologic systemic lupus erythematosus.

Moura CA1, Santiago M2, Neto J3, Gomes de Souza VH4, Moura CG5.
Lupus.Lupus.2016 Jun 30. pii: 0961203316657436. [Epub ahead of print]
The relationship between primary hematologic disease and rheumatologic manifestations is well known, especially acute lymphocytic leukemia, lymphomas, plasma cell dyscrasias and myelodysplastic syndrome (MDS). Currently, more has been described about autoimmune manifestations in chronic myelomonocyt
PMID 27365372

Activity of the oral mitogen-activated protein kinase kinase inhibitor trametinib in RAS-mutant relapsed or refractory myeloid malignancies.

Borthakur G1, Popplewell L2, Boyiadzis M3, Foran J4, Platzbecker U5, Vey N6, Walter RB7, Olin R8, Raza A9, Giagounidis A10, Al-Kali A11, Jabbour E1, Kadia T1, Garcia-Manero G1, Bauman JW12, Wu Y13, Liu Y14, Schramek D15, Cox DS16, Wissel P17, Kantarjian H1.
Cancer.Cancer.2016 Jun 15;122(12):1871-9. doi: 10.1002/cncr.29986. Epub 2016 Mar 18.
BACKGROUND: RAS/RAF/mitogen-activated protein kinase activation is common in myeloid malignancies. Trametinib, a mitogen-activated protein kinase kinase 1 (MEK1)/MEK2 inhibitor with activity against multiple myeloid cell lines at low nanomolar concentrations, was evaluated for safety and clinical ac
PMID 26990290

Japanese Journal

造血器腫瘍におけるTET2のゲートキーパーとしての役割

武藤秀治,坂田（柳元）麻実子,千葉滋
臨床血液 56(6), 651-656, 2015
TET (Ten Eleven Translocation)ファミリータンパク質はメチルシトシンをヒドロキシメチルシトシンに変換する酵素であり，DNAの脱メチル化に重要な役割を果たしている。中でもTET2遺伝子異常は，骨髄異形成症候群，骨髄増殖性腫瘍，慢性骨髄単球性白血病，急性骨髄性白血病などの骨髄球系造血器腫瘍のみならず，血管免疫芽球性T細胞性リンパ腫，分類不能型末梢性T細胞性リンパ腫の一部とい …
NAID 130005093097

症例報告心タンポナーデを契機に診断された急性骨髄単球性白血病の1例

熊野梨奈,中村秀志,小池隆夫 [他]
広島医学 67(10), 690-694, 2014-10
NAID 40020255175

髄液中に白血病細胞が検出された急性骨髄単球性白血病の1例

大城雄介,手塚俊介,花井亜莉沙,土橋悦子,長谷川達朗,土井誠一,宮崎澄夫
医学検査 63(3), 327-330, 2014
患者は咳嗽，発熱，頭痛，眼瞼腫脹，下肢痛，歩行失行を主訴とし当院小児科外来を受診した1歳男児．血液像検査で異常細胞が認められなかったにもかかわらず，髄液サムソン染色で大型，N/C比大，核小体明瞭，核クロマチン構造が繊細な細胞が孤立散在性に認められた．血液疾患が疑われた為，髄液検体を用いてメイグリュンワルド・ギムザ染色，ペルオキシダーゼ染色，エステラーゼ二重染色を行った．メイグリュンワルド・ギムザ染 …
NAID 130004601865