出典: meddic

zeta-associated protein-70

zeta-associated protein 70

  • ZAP-70は2つのSH2ドメインを有するチロシンキナーゼである。

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2017/08/28 14:29:29」(JST)

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  • Clinical Monoclonal B Lymphocytosis versus Rai 0 Chronic Lymphocytic Leukemia: A Comparison of Cellular, Cytogenetic, Molecular, and Clinical Features.
  • Morabito F, Mosca L, Cutrona G, Agnelli L, Tuana G, Ferracin M, Zagatti B, Lionetti M, Fabris S, Maura F, Matis S, Gentile M, Vigna E, Colombo M, Massucco C, Recchia AG, Bossio S, De Stefano L, Ilariucci F, Musolino C, Molica S, Di Raimondo F, Cortelezzi A, Tassone P, Negrini M, Monti S, Rossi D, Gaidano G, Ferrarini M, Neri A.SourceAuthors' Affiliations: Department of Onco-Hematology, A.O. of Cosenza, Cosenza; Department of Clinical Sciences and Community Health, University of Milano and Hematology 1 CTMO, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano; SS Molecular Diagnostics, Scientific Direction, and Direzione Scientifica, IRCCS, San Martino IST, Genoa; Department of Experimental and Diagnostic Medicine, University of Ferrara, Ferrara; Division of Hematology, A.O. Arcispedale Santa Maria Nuova-IRCCS, Reggio Emilia; Division of Hematology, University of Messina, Messina; Department of Oncology and Hematology, Pugliese-Ciaccio Hospital; University of Magna Graecia and Cancer Center, Catanzaro; Division of Hematology, Department of Biomedical Sciences, University of Catania and Ferrarotto Hospital, Catania; and Division of Hematology, Department of Clinical and Experimental Medicine, Amedeo Avogadro University of Eastern Piedmont, Novara, Italy.
  • Clinical cancer research : an official journal of the American Association for Cancer Research.Clin Cancer Res.2013 Nov 1;19(21):5890-900. doi: 10.1158/1078-0432.CCR-13-0622. Epub 2013 Sep 13.
  • PURPOSE: To investigate the incidence and clinical relevance of classic and new prognostic markers, IGHV gene mutational status, and chromosomal abnormalities in clinical monoclonal B lymphocytosis (cMBL) compared with Rai stage 0 chronic lymphocytic leukemia (Rai0-CLL).EXPERIMENTAL DESIGN: A group
  • PMID 24036852
  • Neutrophil cell surface receptors and their intracellular signal transduction pathways.
  • Futosi K, Fodor S, Mócsai A.SourceDepartment of Physiology, Semmelweis University School of Medicine, 1094 Budapest, Hungary.
  • International immunopharmacology.Int Immunopharmacol.2013 Nov;17(3):638-50. doi: 10.1016/j.intimp.2013.06.034. Epub 2013 Aug 30.
  • Neutrophils play a critical role in the host defense against bacterial and fungal infections, but their inappropriate activation also contributes to tissue damage during autoimmune and inflammatory diseases. Neutrophils express a large number of cell surface receptors for the recognition of pathogen
  • PMID 23994464
  • Immunoregulatory Effects of Interferon-β in Suppression of Th17 cells.
  • Pennell LM, Fish EN.Source1 Toronto General Research Institute, University Health Network , Toronto, Canada .
  • Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.J Interferon Cytokine Res.2013 Oct 31. [Epub ahead of print]
  • To investigate the immunoregulatory effects of interferon (IFN)-β on CD4+ T cells, we examined the response of CD4+ T cells from IFN-β+/+ and IFN-β-/- mice to CD3/CD28 activation and to differentiation to Th17 lineage, analyzing the expression of signaling effectors, cell surface receptors, produ
  • PMID 24175628


  • HTLV-1 bZIP Factor Enhances T-Cell Proliferation by Impeding the Suppressive Signaling of Co-inhibitory Receptors
  • ZAP70の変異と自己免疫疾患
  • ZAP70の変異と自己免疫疾患 (特集 自己免疫疾患の発症関与要因)


LYMPHOCYTE SIGNALING ZAP-70 Zap-70は、T細胞とNK細胞に発現するSykファミリーのタンパクチロシンキナーゼで、T細胞レセプター(TCR)を介したT細胞の活性化に重要な役割を担っています。TCR結合に引き続き、Zap-70の複数の ...
Method This 4-color flow cytometry assay utilizes ZAP-70, CD3, CD19, and CD45 monoclonal antibodies. The fluorescently labeled lymphocyte population is selected by CD45 versus side scatter gating. The percentages of ...



拡張検索ZAP-70 protein-tyrosine kinase





  T細胞 B細胞
抗原受容体 TCR(β鎖, α鎖) BCR(H鎖, L鎖)
受容体に付随するタンパク質 CD3δ Igα
CD3ε Igβ
CD5 CD19
CD6 CD22
Src kinase Lck, Fyn Kyn, Blk, Fyn
Syc kinase
ZAP-70 kinase
ZAP-70,Syk Syk
Down stream enzymes MAP kinase  
PLCγ1 PLCγ1, PLCγ2
GAP(+/-) GAP
  PI3 kinase
Others Ezrin  
Valosin-containing protein  

ZAP-70 protein-tyrosine kinase」





WordNet   license wordnet

「strike suddenly and with force; "This show zaps the viewers with some shocking scenes"」

WordNet   license wordnet

「a sudden event that imparts energy or excitement, usually with a dramatic impact; "they gave it another zap of radiation"」

PrepTutorEJDIC   license prepejdic

「(特にすばやく)…‘を'殺す,撃つ,滅ぼす / すばやく動く / 活力,活気;攻撃」

WordNet   license wordnet

「kill with or as if with a burst of gunfire or electric current or as if by shooting; "in this computer game, space travellers are vaporized by aliens"」




WordNet   license wordnet

「the 26th letter of the Roman alphabet; "the British call Z zed and the Scots call it ezed but Americans call it zee"; "he doesn''t know A from izzard"」
z, zee, zed, ezed, izzard

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