- 同
- lymphotactin
- 同
- lymphotactin
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/08/24 08:24:35」(JST)
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chemokine (C motif) ligand 1, lymphotactin |
Identifiers |
Symbol |
XCL1 |
Alt. symbols |
SCYC1, LTN, LPTN, ATAC, SCM-1a, SCM-1 |
Entrez |
6375 |
HUGO |
10645 |
OMIM |
600250 |
RefSeq |
NM_002995 |
UniProt |
P47992 |
Other data |
Locus |
Chr. 1 q24.2 |
Chemokine (C motif) ligand (XCL1) is a small cytokine belonging to the XC chemokine family that is also known as lymphotactin. It is found in high levels in spleen, thymus, intestine and peripheral blood leukocytes, and at lower levels in lung, prostate gland and ovary. Cellular sources for XCL1 include activated thymic and peripheral blood CD8+ T cells.[1][2][3] This chemokine attracts T cells. In humans, XCL1 is closely related to another chemokine called XCL2, whose gene is found at the same locus on chromosome 1.[3] XCL1 induces it chemotactic function by binding to a chemokine receptor called XCR1.[4]
Lymphotactin, LTN, is found in two states: a monomer at 10 °C, LTN10, and a dimer at 40 °C, LTN40.[5]
References
- ^ Kelner G, Kennedy J, Bacon K, Kleyensteuber S, Largaespada D, Jenkins N, Copeland N, Bazan J, Moore K, Schall T, Zlotnik A (1994). "Lymphotactin: a cytokine that represents a new class of chemokine". Science 266 (25): 1395–9. PMID 7973732.
- ^ Kennedy J, Kelner G, Kleyensteuber S, Schall T, Weiss M, Yssel H, Schneider P, Cocks B, Bacon K, Zlotnik A (1995). "Molecular cloning and functional characterization of human lymphotactin". J Immunol 155 (1): 203–9. PMID 7602097.
- ^ a b Yoshida T, Imai T, Takagi S, Nishimura M, Ishikawa I, Yaoi T, Yoshie O (1996). "Structure and expression of two highly related genes encoding SCM-1/human lymphotactin". FEBS Lett 395 (1): 82–8. doi:10.1016/0014-5793(96)01004-6. PMID 8849694.
- ^ Yoshida T, Imai T, Kakizaki M, Nishimura M, Takagi S, Yoshie O (1998). "Identification of single C motif-1/lymphotactin receptor XCR1". J Biol Chem 273 (26): 16551–4. doi:10.1074/jbc.273.26.16551. PMID 9632725.
- ^ Tyler, Robert C.; Tyler, R. C.; Murray, N. J.; Peterson, F. C.; Volkman, B. F. (2011). "Native state interconversion of a metamorphic protein requires global unfolding". Biochemistry 50 (33): 7077–9. doi:10.1021/bi200750k. PMC 3160782. PMID 21776971.
Cell signaling: cytokines
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By family |
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By function/
cell |
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Index of signal transduction
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Description |
- Intercellular
- neuropeptides
- growth factors
- cytokines
- hormones
- Cell surface receptors
- ligand-gated
- enzyme-linked
- G protein-coupled
- immunoglobulin superfamily
- integrins
- neuropeptide
- growth factor
- cytokine
- Intracellular
- adaptor proteins
- GTP-binding
- MAP kinase
- Calcium signaling
- Lipid signaling
- Pathways
- hedgehog
- Wnt
- TGF beta
- MAPK ERK
- notch
- JAK-STAT
- apoptosis
- hippo
- TLR
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English Journal
- Apoptosis induction and release of inflammatory cytokines in the oviduct of egg-laying hens experimentally infected with H9N2 avian influenza virus.
- Wang J1, Tang C2, Wang Q2, Li R2, Chen Z2, Han X2, Wang J2, Xu X3.
- Veterinary microbiology.Vet Microbiol.2015 Jun 12;177(3-4):302-14. doi: 10.1016/j.vetmic.2015.04.005. Epub 2015 Apr 14.
- The H9N2 subtype avian influenza virus (AIV) can cause serious damage to the reproductive tract of egg-laying hens, leading to severe egg-drop and poor egg shell quality. However, previous studies in relation to the oviductal-dysfunction resulted from this agent have not clearly been elucidated. In
- PMID 25911114
- Laser-Assisted Intradermal Delivery of Adjuvant-Free Vaccines Targeting XCR1+ Dendritic Cells Induces Potent Antitumoral Responses.
- Terhorst D1, Fossum E2, Baranska A3, Tamoutounour S3, Malosse C3, Garbani M4, Braun R5, Lechat E5, Crameri R4, Bogen B6, Henri S7, Malissen B7.
- Journal of immunology (Baltimore, Md. : 1950).J Immunol.2015 May 4. pii: 1500564. [Epub ahead of print]
- The development of vaccines inducing efficient CD8+ T cell responses is the focus of intense research. Dendritic cells (DCs) expressing the XCR1 chemokine receptor, also known as CD103+ or CD8α+ DCs, excel in the presentation of extracellular Ags to CD8+ T cells. Because of its high numbers of DCs,
- PMID 25941327
- Myeloperoxidase Is Increased in Human Cerebral Aneurysms and Increases Formation and Rupture of Cerebral Aneurysms in Mice.
- Chu Y1, Wilson K1, Gu H1, Wegman-Points L1, Dooley SA1, Pierce GL1, Cheng G1, Silva RA1, Heistad DD1, Hasan D2.
- Stroke; a journal of cerebral circulation.Stroke.2015 Apr 28. pii: STROKEAHA.114.008589. [Epub ahead of print]
- BACKGROUND AND PURPOSE: Cerebral aneurysm (CA) affects 3% of the population and is associated with hemodynamic stress and inflammation. Myeloperoxidase, a major oxidative enzyme associated with inflammation, is increased in patients with CA, but whether myeloperoxidase contributes to CA is not known
- PMID 25922506
Japanese Journal
- アフリカツメガエル血清レクチンXCL1の特性とLPSによる発現誘導(平成24年度大学院理学研究科修士論文題目と要旨)
- The Chemokines CXCL10 and XCL1 Recruit Human Annulus Fibrosus Cells
- HEGEWALD Aldemar A.,NEUMANN Katja,KALWITZ Gregor,FREYMANN Undine,ENDRES Michaela,SCHMIEDER Kirsten,KAPS Christian,THOME Claudius
- Spine 37(2), 101-107, 2012-01-15
- NAID 10030903550
- XCL1 and XCR1 in the immune system
Related Links
- Complete information for XCL1 gene (Protein Coding), Chemokine (C Motif) Ligand 1, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium ... This antimicrobial ...
- 1. Microbes Infect. 2012 Mar;14(3):262-7. doi: 10.1016/j.micinf.2011.10.003. Epub 2011 Oct 31. XCL1 and XCR1 in the immune system. Lei Y, Takahama Y. Key Laboratory of Molecular Biology for Infectious Disease ...
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