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V-type ATPasevacuolar ATPasevacuolar H+-ATPasevacuolar proton-translocating ATPase

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/03/26 20:40:45」(JST)

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  • Vacuolar H+ ATPase expression and activity is required for Rab27B-dependent invasive growth and metastasis of breast cancer.
  • Hendrix A, Sormunen R, Westbroek W, Lambein K, Denys H, Sys G, Braems G, Van den Broecke R, Cocquyt V, Gespach C, Bracke M, De Wever O.SourceLaboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium; Department of Medical Oncology, Ghent University Hospital, Ghent, Belgium.
  • International journal of cancer. Journal international du cancer.Int J Cancer.2013 Aug 15;133(4):843-54. doi: 10.1002/ijc.28079. Epub 2013 Mar 7.
  • The secretory Rab27B small GTPase promotes invasive growth and metastasis in estrogen receptor (ER) α-positive breast cancer cells by orchestrating the peripheral targeting of vesicles secreting proinvasive growth regulators. Increased Rab27B expression is associated with poor prognosis in breast c
  • PMID 23390068
  • V-ATPase is a candidate therapeutic target for Ewing sarcoma.
  • Avnet S, Di Pompo G, Lemma S, Salerno M, Perut F, Bonuccelli G, Granchi D, Zini N, Baldini N.SourceLaboratory for Orthopaedic Pathophysiology and Regenerative Medicine, Istituto Ortopedico Rizzoli, via di Barbiano 1/10, 40136, Bologna, Italy. Electronic address: sofia.avnet@ior.it.
  • Biochimica et biophysica acta.Biochim Biophys Acta.2013 Aug;1832(8):1105-16. doi: 10.1016/j.bbadis.2013.04.003. Epub 2013 Apr 8.
  • Suppression of oxidative phosphorylation combined with enhanced aerobic glycolysis and the resulting increased generation of protons are common features of several types of cancer. An efficient mechanism to escape cell death resulting from intracellular acidification is proton pump activation. In Ew
  • PMID 23579072
  • Effect of pantoprazole on human gastric adenocarcinoma SGC7901 cells through regulation of phospho‑LRP6 expression in Wnt/β-catenin signaling.
  • Shen W, Zou X, Chen M, Shen Y, Huang S, Guo H, Zhang L, Liu P.SourceDepartment of Digestive Disease, Gastrointestinal Center, Jiangyin People's Hospital, Medical School of the University of Southeast China, Jiangyin, Jiangsu 214400. P.R. China.
  • Oncology reports.Oncol Rep.2013 Aug;30(2):851-5. doi: 10.3892/or.2013.2524. Epub 2013 Jun 7.
  • Recent studies have found that an acidic tumor microenvironment is the key to managing cancer progression and metastasis. Our previous study found that proton pump inhibitors (PPIs) inhibit the expression of vacuolar-ATPases (V-ATPases) and reverse the transmembrane pH gradient. The present study wa
  • PMID 23754096


  • Enhanced Cell Expansion in a KRP2 Overexpressor is Mediated by Increased V-ATPase Activity
  • Ferjani Ali,Ishikawa Kazuki,Asaoka Mariko [他]
  • Plant and cell physiology 54(12), 1989-1998, 2013-12
  • NAID 40019938257
  • 網膜神経回路におけるH⁺負帰還信号の分子機構としてのV-ATPase
  • 山田 雅弘
  • 比較生理生化学 = Comparative physiology and biochemistry 30(4), 183-193, 2013
  • NAID 40019906140
  • Increased production of reactive oxygen species by the vacuolar-type (H+)-ATPase inhibitors bafilomycin A1 and concanamycin A in RAW 264 cells
  • YOKOMAKURA Aya,HONG JangJa,OHUCHI Kazuo,OH Seong-Eun,LEE Jin-Yong,MANO Nariyasu,TAKAHASHI Tsutomu,HWANG Gi-Wook,NAGANUMA Akira
  • Journal of toxicological sciences 37(5), 1045-1048, 2012-10-01
  • NAID 10030876740


Vacuolar-type H+-ATPase (V-ATPase) is a highly conserved evolutionarily ancient enzyme with remarkably diverse functions in eukaryotic organisms. V- ATPases acidify a wide array of intracellular organelles and pump protons across the ...


間 距離 測定 により v atpase The V-ATPase proton pump maintains proper FIGURE 3 | Assembly of the V-ATPase Structure and evolution of the V-ATPase Les inhibiteurs des pompes à protons : un Targeting of V-ATPase complexes:

リンク元液胞型プロトンポンプ」「vacuolar H+-ATPase」「vacuolar proton-translocating ATPase」「vacuolar ATPase」「V-type ATPase



vacuolar proton-translocating ATPasevacuolar H+-ATPaseV-ATPase

vacuolar H+-ATPase」


V-ATPaseV-type ATPasevacuolar ATPasevacuolar proton-translocating ATPase

vacuolar proton-translocating ATPase」


V-ATPaseV-type ATPasevacuolar ATPasevacuolar H+-ATPase

vacuolar ATPase」



V-ATPaseV-type ATPasevacuolar H+-ATPasevacuolar proton-translocating ATPase

V-type ATPase」


V-ATPasevacuolar ATPasevacuolar H+-ATPasevacuolar proton-translocating ATPase



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「the 22nd letter of the Roman alphabet」

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「vanadium の化学記号」



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「verb / verso / 《話》very / velocity / volt[s] / volume / vide」





ATP hydrolase