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1. 酸関連疾患治療のためのプロトンポンプ阻害剤の概要および比較 overview and comparison of the proton pump inhibitors for the treatment of acid related disorders
2. 成人における難治性胃食道逆流症へのアプローチ approach to refractory gastroesophageal reflux disease in adults
3. 抗潰瘍剤の薬理学 pharmacology of antiulcer medications
4. 出血性消化性潰瘍の治療の概要 overview of the treatment of bleeding peptic ulcers
5. 咽喉頭逆流 laryngopharyngeal reflux

RAF265, a dual BRAF and VEGFR2 inhibitor, prevents osteoclast formation and resorption. Therapeutic implications.

Garcia-Gomez A, Ocio EM, Pandiella A, San Miguel JF, Garayoa M.SourceCentro de Investigación del Cáncer, IBMCC (Universidad de Salamanca-CSIC), Campus Miguel de Unamuno, Avda. Coimbra s/n, 37007, Salamanca, Spain.
Investigational new drugs.Invest New Drugs.2013 Feb;31(1):200-5. doi: 10.1007/s10637-012-9845-3. Epub 2012 Jul 7.
Introduction The RAS/RAF/MEK/ERK signaling pathway plays an important role in osteoclast (OC) differentiation and survival mediated by macrophage-colony stimulating factor (M-CSF). Also, vascular endothelial growth factor (VEGF) may greatly influence OC formation and resorption through VEGFR1 and VE
PMID 22773056

SLC4A2-mediated Cl-/HCO3- exchange activity is essential for calpain-dependent regulation of the actin cytoskeleton in osteoclasts.

Coury F, Zenger S, Stewart AK, Stephens S, Neff L, Tsang K, Shull GE, Alper SL, Baron R, Aliprantis AO.SourceDepartment of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115.
Proceedings of the National Academy of Sciences of the United States of America.Proc Natl Acad Sci U S A.2013 Jan 22. [Epub ahead of print]
Bone remodeling requires osteoclasts to generate and maintain an acidified resorption compartment between the apical membrane and the bone surface to solubilize hydroxyapatite crystals within the bone matrix. This acidification process requires (i) apical proton secretion by a vacuolar H(+)-ATPase,
PMID 23341620

Activation of the proton pump, V-ATPase, triggers JNK-dependent cell invasion and overgrowth in a Drosophila epithelium.

Petzoldt AG, Gleixner EM, Fumagalli A, Vaccari T, Simons M.SourceFreie Universität, Berlin, Germany;
Disease models & mechanisms.Dis Model Mech.2013 Jan 18. [Epub ahead of print]
The C subunit of the vacuolar H(+)-ATPase or V-ATPase regulates the activity and assembly of the proton pump at cellular membranes. It has been shown to be strongly upregulated in oral squamous cell carcinoma, a highly metastatic epithelial cancer. In addition, increased V-ATPase activity appears to
PMID 23335205

Increased production of reactive oxygen species by the vacuolar-type (H+)-ATPase inhibitors bafilomycin A1 and concanamycin A in RAW 264 cells

YOKOMAKURA Aya,HONG JangJa,OHUCHI Kazuo,OH Seong-Eun,LEE Jin-Yong,MANO Nariyasu,TAKAHASHI Tsutomu,HWANG Gi-Wook,NAGANUMA Akira
Journal of toxicological sciences 37(5), 1045-1048, 2012-10-01
NAID 10030876740