- 同
- transporter associated with antigen presentation 2
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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/04/04 22:38:10」(JST)
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Transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) |
Identifiers |
Symbols |
TAP2 (; ABC18; ABCB3; APT2; D6S217E; PSF-2; PSF2; RING11) |
External IDs |
OMIM: 170261 MGI: 98484 HomoloGene: 37323 GeneCards: TAP2 Gene |
Gene Ontology |
Molecular function |
• transporter activity
• protein binding
• ATP binding
• peptide transporter activity
• oligopeptide-transporting ATPase activity
• peptide antigen-transporting ATPase activity
• MHC class I protein binding
• peptide antigen binding
• TAP1 binding
• TAP2 binding
• tapasin binding
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Cellular component |
• nucleus
• mitochondrial inner membrane
• endoplasmic reticulum
• endoplasmic reticulum membrane
• plasma membrane
• integral to membrane
• integral to endoplasmic reticulum membrane
• TAP complex
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Biological process |
• positive regulation of T cell mediated cytotoxicity
• antigen processing and presentation of peptide antigen via MHC class I
• antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
• antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
• antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent
• antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent
• positive regulation of antigen processing and presentation of peptide antigen via MHC class I
• peptide transport
• intracellular transport of viral proteins in host cell
• antigen processing and presentation of endogenous peptide antigen via MHC class I
• antigen processing and presentation of exogenous peptide antigen via MHC class I
• cytosol to ER transport
• peptide antigen transport
• transmembrane transport
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Sources: Amigo / QuickGO |
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RNA expression pattern |
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More reference expression data |
Orthologs |
Species |
Human |
Mouse |
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Entrez |
6891 |
21355 |
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Ensembl |
ENSG00000204267 |
ENSMUSG00000024339 |
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UniProt |
Q03519 |
P36371 |
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RefSeq (mRNA) |
NM_000544 |
NM_011530 |
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RefSeq (protein) |
NP_000535 |
NP_035660 |
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Location (UCSC) |
Chr 6:
32.79 – 32.81 Mb |
Chr 17:
34.2 – 34.22 Mb |
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PubMed search |
[1] |
[2] |
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TAP2 is a gene in humans that encodes the protein Antigen peptide transporter 2.[1][2][3]
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This gene is located 7 kb telomeric to gene family member ABCB2. The protein encoded by this gene is involved in antigen presentation. This protein forms a heterodimer with ABCB2 in order to transport peptides from the cytoplasm to the endoplasmic reticulum. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, schizophrenia,[4] and celiac disease. Alternative splicing of this gene produces two products which differ in peptide selectivity and level of restoration of surface expression of MHC class I molecules.[5]
Contents
- 1 See also
- 2 References
- 3 Further reading
- 4 External links
See also
- ATP-binding cassette transporter
References
- ^ Bodmer JG, Marsh SG, Albert ED, Bodmer WF, Dupont B, Erlich HA, Mach B, Mayr WR, Parham P (Oct 1992). "Nomenclature for factors of the HLA system, 1991. WHO Nomenclature Committee for factors of the HLA system". Tissue Antigens 39 (4): 161–73. PMID 1529427.
- ^ Bahram S, Arnold D, Bresnahan M, Strominger JL, Spies T (Dec 1991). "Two putative subunits of a peptide pump encoded in the human major histocompatibility complex class II region". Proc Natl Acad Sci U S A 88 (22): 10094–8. doi:10.1073/pnas.88.22.10094. PMC 52874. PMID 1946428.
- ^ Hahn Y, Lee B (Feb 2006). "Human-specific nonsense mutations identified by genome sequence comparisons". Hum Genet 119 (1–2): 169–78. doi:10.1007/s00439-005-0125-6. PMID 16395595.
- ^ Yu H. Protein-interaction-network-based analysis for genome-wide association analysis of schizophrenia in Han Chinese population.
- ^ "Entrez Gene: TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)".
Further reading
- Townsend A, Trowsdale J (1993). "The transporters associated with antigen presentation". Semin. Cell Biol. 4 (1): 53–61. doi:10.1006/scel.1993.1007. PMID 8453065.
- Beck S, Kelly A, Radley E et al. (1992). "DNA sequence analysis of 66 kb of the human MHC class II region encoding a cluster of genes for antigen processing". J. Mol. Biol. 228 (2): 433–41. doi:10.1016/0022-2836(92)90832-5. PMID 1453454.
- Kelly A, Powis SH, Kerr LA et al. (1992). "Assembly and function of the two ABC transporter proteins encoded in the human major histocompatibility complex". Nature 355 (6361): 641–4. doi:10.1038/355641a0. PMID 1538751.
- Colonna M, Bresnahan M, Bahram S et al. (1992). "Allelic variants of the human putative peptide transporter involved in antigen processing". Proc. Natl. Acad. Sci. U.S.A. 89 (9): 3932–6. doi:10.1073/pnas.89.9.3932. PMC 525605. PMID 1570316.
- Powis SH, Mockridge I, Kelly A et al. (1992). "Polymorphism in a second ABC transporter gene located within the class II region of the human major histocompatibility complex". Proc. Natl. Acad. Sci. U.S.A. 89 (4): 1463–7. doi:10.1073/pnas.89.4.1463. PMC 48471. PMID 1741401.
- Trowsdale J, Hanson I, Mockridge I et al. (1991). "Sequences encoded in the class II region of the MHC related to the 'ABC' superfamily of transporters". Nature 348 (6303): 741–4. doi:10.1038/348741a0. PMID 2259383.
- de la Salle H (1994). "Homozygous human TAP peptide transporter mutation in HLA class I deficiency". Science 265 (5169): 237–41. doi:10.1126/science.7517574. PMID 7517574.
- Cano P, Baxter-Lowe LA (1995). "Novel human TAP2*103 allele shows further polymorphism in the ATP-binding domain". Tissue Antigens 45 (2): 139–42. doi:10.1111/j.1399-0039.1995.tb02431.x. PMID 7792761.
- Roby KF, Fei K, Yang Y, Hunt JS (1995). "Expression of HLA class II-associated peptide transporter and proteasome genes in human placentas and trophoblast cell lines". Immunology 83 (3): 444–8. PMC 1415039. PMID 7835969.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Singal DP, Ye M, Qiu X, D'Souza M (1994). "Polymorphisms in the TAP2 gene and their association with rheumatoid arthritis". Clin. Exp. Rheumatol. 12 (1): 29–33. PMID 8162639.
- Powis SH, Tonks S, Mockridge I et al. (1993). "Alleles and haplotypes of the MHC-encoded ABC transporters TAP1 and TAP2". Immunogenetics 37 (5): 373–80. doi:10.1007/BF00216802. PMID 8428770.
- Glynne R, Kerr LA, Mockridge I et al. (1993). "The major histocompatibility complex-encoded proteasome component LMP7: alternative first exons and post-translational processing". Eur. J. Immunol. 23 (4): 860–6. doi:10.1002/eji.1830230414. PMID 8458375.
- Beck S, Abdulla S, Alderton RP et al. (1996). "Evolutionary dynamics of non-coding sequences within the class II region of the human MHC". J. Mol. Biol. 255 (1): 1–13. doi:10.1006/jmbi.1996.0001. PMID 8568858.
- Ahn K, Meyer TH, Uebel S et al. (1996). "Molecular mechanism and species specificity of TAP inhibition by herpes simplex virus ICP47". EMBO J. 15 (13): 3247–55. PMC 451885. PMID 8670825.
- Pattanakitsakul S, Takeuchi F, Nabeta H et al. (1996). "A novel TAP 2 gene RFLP observed in a Japanese". Tissue Antigens 47 (4): 353–5. doi:10.1111/j.1399-0039.1996.tb02567.x. PMID 8773329.
- Lewis JW, Neisig A, Neefjes J, Elliott T (1997). "Point mutations in the alpha 2 domain of HLA-A2.1 define a functionally relevant interaction with TAP". Curr. Biol. 6 (7): 873–83. doi:10.1016/S0960-9822(02)00611-5. PMID 8805302.
External links
- TAP2 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
Membrane proteins, carrier proteins: membrane transport proteins ABC-transporter (TC 3A1)
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A |
- A1
- A2
- A3
- A4
- A7
- A8
- A12
- A13
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B |
- B1
- B2-3 (B2
- B3)
- B4
- B5
- B6
- B7
- B9
- B11
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C |
- C1
- C2
- C3
- C4
- C5
- C6
- C7
- C8-9 (C8, C9)
- C10
- C11
- C13
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D |
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E |
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F |
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G |
- G1
- G2
- G4
- Sterolin (G5, G8)
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see also ABC transporter disorders
B memb: cead, trns (1A, 1C, 1F, 2A, 3A1, 3A2-3, 3D), other
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UpToDate Contents
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English Journal
- Analysis of HLA-DM polymorphisms in the Chinese Han population.
- Feng ML, Liu RZ, Shen T, Zhao YL, Zhu ZY, Liu DZ.SourceShanghai Blood Center, Shanghai, China School of Life Science, East China Normal University, Shanghai, China.
- Tissue antigens.Tissue Antigens.2012 Mar;79(3):157-64. doi: 10.1111/j.1399-0039.2012.01838.x.
- Non-classical human leukocyte antigen (HLA)-DM plays an important and unique role in the processing and presentation of exogenous antigens. Polymorphisms of certain genes and frequency of alleles in populations may indicate susceptibility to certain diseases. In this study, the analysis of HLA-DMA a
- PMID 22309257
- Clonal Evolution Including Partial Loss of Human Leukocyte Antigen Genes Favoring Extramedullary Acute Myeloid Leukemia Relapse After Matched Related Allogeneic Hematopoietic Stem Cell Transplantation.
- Stölzel F, Hackmann K, Kuithan F, Mohr B, Füssel M, Oelschlägel U, Thiede C, Röllig C, Platzbecker U, Schetelig J, Illmer T, Schaich M, Seliger B, Hartmann A, Baretton G, Zietz C, Ehninger G, Schrock E, Bornhäuser M.Source1 Medizinische Klinik und Poliklinik I, Universitätsklinikum Carl Gustav Carus, Dresden, Germany. 2 Institut für Klinische Genetik, Universitätsklinikum Carl Gustav Carus, Dresden, Germany. 3 Institut für Pathologie, Universitätsklinikum Carl Gustav Carus, Dresden, Germany. 4 DKMS Life Science Lab GmbH, Dresden, Germany. 5 Institut für Medizinische Immunologie, Medizinische Fakultät der Martin-Luther-Universität, Halle-Wittenberg, Halle/Saale, Germany. 6 Institut für Pathologie, Universitätsklinikum Erlangen, Erlangen, Germany.
- Transplantation.Transplantation.2012 Feb 6. [Epub ahead of print]
- BACKGROUND: Relapse of acute myeloid leukemia (AML) after allogeneic hematopoietic stem cell transplantation (HSCT) leaves few therapeutic options, and mechanisms of immune escape of recurring leukemic cells remain poorly understood. Recently, acquired loss of mismatched human leukocyte antigen (HLA
- PMID 22314337
Japanese Journal
- Genetic association analysis of TAP1 and TAP2 polymorphisms with aspirin exacerbated respiratory disease and its FEV1 decline
- Kim Jeong-Hyun,Park Byung-Lae,Pasaje Charisse Flerida A. [他],BAE Joon Seol,PARK Jong Sook,PARK Sung Woo,UH Soo-Taek,KIM Mi-Kyeong,CHOI Inseon S,CHO Sang Heon,CHOI Byoung Whui,PARK Choon-Sik,SHIN Hyoung Doo
- Journal of human genetics 56(9), 652-659, 2011-09-01
- NAID 10030660849
- TAP1 and TAP2 gene polymorphisms in childhood cystic echinococcosis
- KIPER Nural,GERCEKER Filiz,UTINE Eda,YALCIN Ebru,PEKCAN Sevgi,COBANOGLU Nazan,ASLAN Ayse,KOSE Mehmet,DOGRU Deniz,OZCELIK Ugur,OZGUC Meral
- Parasitology international : official journal of the Japanese Society of Parasitology 59(2), 283-285, 2010-06-01
- NAID 10029824579
- Correlation between expression of major histocompatibility complex class I and that of antigen presenting machineries in carcinoma cell lines of the pancreas, biliary tract and colon
- Imanishi Tatsuya,Kamigaki Takashi,Nakamura Tetsu,Hayashi Shun,Yasuda Takashi,Kawasaki Kentaro,Takase Shiro,Ajiki Tetsuo,Kuroda Yoshikazu
- The Kobe journal of the medical sciences 52(3/4), 85-95, 2006-00-00
- … Quantitative real-time PCR demonstrated lower expression for TAP1, TAP2,LMP2 and LMP7 gene in five cancer cell lines. …
- NAID 110004792455
Related Links
- 有限会社タップ擬人化キャラ製作計画(仮) (http://chara.tap2.jp/) オンラインショップ始めました。 タップオンラインショップ (http://sign-tap.ocnk.net/) 作ったもの(動画) ・YouTube http://www.youtube.com/user/stsuna00 ・ニコニコ動画 ...
- TAP三人娘のwebページへようこそ。 information お知らせ 2013/8/10 御社香里UTAU音源を公開しました。 2013/6/20 御社香里のUTAU音源の中の人を募集してます。(7/3まで) 2012/4/80 サイトをリニューアルしました。
Related Pictures
★リンクテーブル★
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- 関
- TAP-1, TAP-2
- TAP-1
- TAP-2
- ATP-binding cassete family(ABC family)に属する
- ATPのエネルギーでイオン、糖、アミノ酸、ペプチドを運ぶ
- インターフェロンでTAPの発現が上昇する
- 遺伝子はMHC class IIIに存在する
- TAPは8-16残基のペプチド、C末端が疎水性残基か塩基性残基をよく輸送し、
- MHC class Iに結合するペプチドの特徴に一致する (IMM.184)
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