T-SPOT.TB

同

interferon-y release assays

WordNet

1. mark with a spot or spots so as to allow easy recognition; "spot the areas that one should clearly identify"
2. a small piece or quantity of something; "a spot of tea"; "a bit of paper"; "a bit of lint"; "I gave him a bit of my mind" (同)bit
3. a small contrasting part of something; "a bald spot"; "a leopards spots"; "a patch of clouds"; "patches of thin ice"; "a fleck of red" (同)speckle, dapple, patch, fleck, maculation
4. a business establishment for entertainment; "night spot"
5. a playing card with a specified number of pips on it to indicate its value; "an eight-spot"
6. a mark on a die or on a playing card (shape depending on the suit) (同)pip
7. a section of an entertainment that is assigned to a specific performer or performance; "they changed his spot on the program"
8. a short section or illustration (as between radio or tv programs or in a magazine) that is often used for advertising
9. make a spot or mark onto; "The wine spotted the tablecloth" (同)fleck, blob, blot
10. detect with the senses; "The fleeing convicts were picked out of the darkness by the watchful prison guards"; "I cant make out the faces in this photograph" (同)recognize, recognise, distinguish, discern, pick out, make_out, tell apart
11. become spotted; "This dress spots quickly"
12. the 20th letter of the Roman alphabet (同)t
13. a tough youth of 1950s and 1960s wearing Edwardian style clothes (同)Teddy boy

PrepTutorEJDIC

1. 『斑点』(はんてん),まだら,ぶち;(太陽の)黒点 / 『しみ』,よごれ;吹出物,にきび / (…に対する)汚名,汚点《+『on』+『名』》 / 『場所』,地点;部分,箇所 / (順序・組織における)位置;立場,おかれた状況 / 《a spot》《英話》(…の)少量,ちょっぴり(の…);(…の)1杯《+『of』+『名』》 / (ラジオ・テレビ番組の)構成区分 / …‘を'『しみで汚す』,‘に'汚れをつける;…‘に'斑点(はんてん)をつける,‘を'まだら(ぶち)にする;( …で)…‘に'しみ(斑点)をつける《+『名』+『with』+『名』》 / 〈人格・名声など〉‘を'汚す,傷つける / (特定の場所に)…‘を'置く,配置する / …‘を'見つける;(…だと)…‘を'見抜く《+『名』+『as』(『for』)+『名』》 / 〈インクなどが〉『しみになる』;〈布などが〉汚れる / 即座になされる,即時払いの(引き渡しの) / 現場での,現地の / (ラジオ・テレビで)番組の間に放送される / ちょうど,ぴったり(exactly)
2. tritiumの化学記号
3. Shore Patrol / Specialist

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/05/21 23:44:53」(JST)

wiki en

[Wiki en表示]

T-SPOT.TB is a type of ELISPOT assay used for tuberculosis diagnosis, which belongs to the group of interferon-gamma release assays. The test is manufactured by Oxford Immunotec in the UK. It is available in most European countries, the United States as well as various other countries. It was developed by researchers at the University of Oxford in England.

Test overview

T_SPOT.TB counts the number of anti-mycobacterial effector T cells, white blood cells that produce interferon-gamma, in a sample of blood. This gives an overall measurement of the host immune response against mycobacteria, which can reveal the presence of infection with Mycobacterium tuberculosis, the causative agent of tuberculosis (TB). Because this does not rely on production of a reliable antibody response or recoverable pathogen, the technique can be used to detect latent tuberculosis. This technique has the advantage that it is comparatively fast (results within 24 hours), and less influenced by previous BCG vaccination compared with the traditional testing method for latent tuberculosis, the tuberculin skin test. This is due to the fact that both tests use different antigens for stimulation. While the tuberculin skin test uses purified protein derivative, a heterogeneous mixture of more than two hundred different mycobacterial peptides, the T-SPOT.TB uses relatively Mycobacterium tuberculosis-specific antigens (peptides called ESAT-6 and CFP-10). ESAT-6 and CFP-10 are expressed by Mycobacterium tuberculosis, but absent are from all currently used BCG vaccines and most nontuberculous mycobacteria. Based on those test principles, it is thought that the T-SPOT.TB is more specific than the tuberculin skin test.

Test performance

In one study in Germany, 70 out of 72 patients with confirmed TB infection were T-SPOT.TB positive, indicating a sensitivity of 97.2%. However, more recent data from a study in children with active TB disease in the UK suggest that the sensitivity of the T-SPOT.TB may in fact be worse than that of the tuberculin skin test (sensitivity reported as 66% and 82%, respectively). The performance of interferon-gamma release assays in children has also been questioned by other publications. A metaanalysis of studies in children with active tuberculosis published in 2011 suggests that the sensitivity of the T-SPOT.TB is very similar to that of the tuberculin skin test (pooled sensitivity reported as 84% and 80%, respectively). http://en.wikipedia.org/wiki/Tuberculosis_diagnosis#Interferon-.CE.B3_release_assays

References

External links

• T-SPOT.TB blood test for tuberculosis
• Oxford Immunotec Ltd.

UpToDate Contents

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• 1. 潜在結核感染診断のためのインターフェロン遊離試験（IGRA） interferon gamma release assays for diagnosis of latent tuberculosis infection
• 2. HIV感染患者における結核性胸水 tuberculous pleural effusions in hiv infected patients
• 3. HIV感染患者における潜在結核感染症の診断 diagnosis of latent tuberculosis infection in hiv infected patients
• 4. 結核における腎疾患 renal disease in tuberculosis
• 5. 薬剤耐性結核の疫学および分子メカニズム epidemiology and molecular mechanisms of drug resistant tuberculosis

English Journal

• Tests for Latent Tuberculosis in People With ESRD: A Systematic Review.

• Rogerson TE, Chen S, Kok J, Hayen A, Craig JC, Sud K, Kable K, Webster AC.SourceCentre for Kidney Research, The Children's Hospital at Westmead, Westmead, Australia; Sydney School of Public Health, University of Sydney, Sydney, Australia.
• American journal of kidney diseases : the official journal of the National Kidney Foundation.Am J Kidney Dis.2013 Jan;61(1):33-43. doi: 10.1053/j.ajkd.2012.07.019. Epub 2012 Oct 13.
• BACKGROUND: The relative diagnostic accuracy of interferon γ release assays (IGRAs; based on ELISA [enzyme-linked immunosorbent assay] or ELISPOT [enzyme-linked immunosorbent spot], ie, the QuantiFERON and T-SPOT.TB tests, respectively) and the tuberculin skin test (TST) for latent tuberculosis (TB
• PMID 23068425

• Interferon gamma mRNA quantitative real-time polymerase chain reaction for the diagnosis of latent tuberculosis: a novel interferon gamma release assay.

• Kim S, Kim YK, Lee H, Cho JE, Kim HY, Uh Y, Kim YM, Kim H, Cho SN, Jeon BY, Lee H.SourceDepartment of Biomedical Laboratory Science, College of Health Sciences, Yonsei University, Wonju, South Korea.
• Diagnostic microbiology and infectious disease.Diagn Microbiol Infect Dis.2013 Jan;75(1):68-72. doi: 10.1016/j.diagmicrobio.2012.09.015. Epub 2012 Oct 24.
• The interferon gamma (IFN-γ) release assay (IGRA) is widely used as a diagnostic method for latent tuberculosis infection (LTBI). The QuantiFERON-TB Gold and QuantiFERON-TB Gold In-tube (QFT-IT) tests measure plasma IFN-γ levels using enzyme-linked immunosorbent assay (ELISA), and T-SPOT.TB counts
• PMID 23102550

• Interferon Gamma Release Assays in the Diagnosis of Latent Tuberculosis Infection Among Immunocompromised Adults.

• Redelman-Sidi G, Sepkowitz KA.SourceInfectious Disease Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, United States.
• American journal of respiratory and critical care medicine.Am J Respir Crit Care Med.2012 Dec 21. [Epub ahead of print]
• Immunocompromised persons with latent tuberculosis infection are at increased risk for tuberculosis reactivation compared to the general population. Tuberculin skin test, the traditional assay for diagnosing LTBI (latent tuberculosis infection), has reduced accuracy in immunocompromised patients. In
• PMID 23262514

Japanese Journal

• 接触者健診におけるT-スポット.TBとQFT-3Gの比較

• 向山 晴子,樋口 一恵,原田 登之
• 結核 89(7), 655-658, 2014-07
• NAID 40020154857

• 同一対象者におけるクォンティフェロンTBゴールド検査とT-スポット.TB検査結果の検討

• 露﨑 みづ枝,岡 馨,石野 彰 [他]
• 調査研究ジャーナル = Chiba survey research journal 3(1), 32-35, 2014
• NAID 40020099958

• Relationship between T-SPOT.TB responses and numbers of circulating CD4+ T-cells in HIV infected patients with active tuberculosis

• Cai Rentian,Chen Jun,Guan Liqian,Sun Meiyan,Sun Yang,Shen Yinzhong,Zhang *Renfang,Liu Li,Lu Hongzhou
• BioScience Trends 8(3), 163-168, 2014
• … This study sought to evaluate the performance of the T-SPOT.TB assay for the diagnosis of active tuberculosis (TB) in human immunodeficiency virus (HIV) infected patients. … One hundred confirmed HIV-infected patients with active TB and known T-SPOT.TB and CD4+ T-cell counts were enrolled in this clinical retrospective study. …
• NAID 130004572598

Related Links

• 新結核用語事典・エリスポット

この方法を用いた結核感染診断キットT-SPOT. TBの検査手順を紹介する。まず、結核 感染の有無を検査する対象者から採血してリンパ球を分離し、抗ヒトインターフェロン- ガンマ（IFN-γ）抗体をコーティングしたpolyvinylidene fluoride (PVDF)膜等で底を覆っ ...

Related Pictures

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★リンクテーブル★

関連記事	「spot」「SP」「T」「TB」

「spot」

　　[★]

• n.

• 点、斑点、局所、スポット

関

dot、local、locoregional、mottle、point、regional、stigma、stigmata

　 　 　 　 　 　 　 　 　 　 　 　

「SP」

　　[★]

• 標準模擬患者 模擬患者 standardized patient
• サブスタンスP
• 肺サーファクタントタンパク質
• station方式
• 同時視 simultaneous perception

　

「T」

　　[★]

• T波 T wave
• チミン thymine
• ツイスト数
• スレオニントレオニン threonine

　 　

「TB」

　　[★]

• 結核 tuberculosis
• total bilirubin