出典: meddic

osteoclast differentiation factorreceptor activator of NF-kappaB ligand
receptor activator for nuclear factor kB ligand

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/08/17 06:22:05」(JST)

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  • Quercetin, a potent suppressor of NF-κB and Smad activation in osteoblasts.
  • Yamaguchi M, Weitzmann MN.Source101 Woodruff Circle, 1329 WMRB, Atlanta, GA 30322, USA.
  • International journal of molecular medicine.Int J Mol Med.2011 Oct;28(4):521-5. doi: 10.3892/ijmm.2011.749. Epub 2011 Jul 14.
  • Osteoclasts, the bone resorbing cells of the body, form when osteoclast precursors are exposed to the key osteoclastogenic cytokine receptor activator of NF-κB ligand (RANKL), a process requiring induction of NF-κB signaling. Quercetin is a ubiquitous plant-derived flavonoid with well documented a
  • PMID 21769418
  • Decreased SH3BP2 inhibits osteoclast differentiation and function.
  • Kawamoto T, Fan C, Gaivin RJ, Levine MA, Lietman SA.SourceDepartment of Anatomic Pathology, The Cleveland Clinic Foundation, Cleveland, Ohio; Department of Biomedical Engineering, The Cleveland Clinic Foundation, Cleveland, Ohio.
  • Journal of orthopaedic research : official publication of the Orthopaedic Research Society.J Orthop Res.2011 Oct;29(10):1521-7. doi: 10.1002/jor.21408. Epub 2011 Mar 29.
  • Germline mutations in SH3BP2 gene have been identified in patients with cherubism, a skeletal disorder characterized by excessive osteoclastic bone resorption that is limited to the mandible and maxilla. We previously demonstrated that SH3BP2 overexpression in Raw264.7 cells increased RANKL-induced
  • PMID 21448930


  • Human bone marrow adipocytes support dexamethasone-induced osteoclast differentiation and function through RANKL expression
  • Goto Hisataka,Osaki Makoto,Fukushima Tatsuya,Sakamoto Kazutaka,Hozumi Akira,Baba Hideo,Shindo Hiroyuki
  • Biomedical Research 32(1), 37-44, 2011-02
  • … The TNF-family molecule, Receptor Activator of Nuclear factor κ B Ligand (RANKL) is known as a key regulator for bone remodeling, and is essential for the development and activation of osteoclasts. … In this study, we examined the regulation of RANKL in primary human bone marrow adipocytes and the relationship between bone marrow adipocytes and bone metabolism. …
  • NAID 120003037548
  • Ablation of the Ccr2 gene exacerbates polyarthritis in interleukin-1 receptor antagonist-deficient mice
  • Fujii Hiroshi,Baba Tomohisa,Ishida Yuko,Kondo Toshikazu ,Yamagishi Masakazu ,Kawano Mitsuhiro ,Mukaida Naofumi 
  • Arthritis and Rheumatism 63(1), 96-106, 2011-01
  • … Infiltrated neutrophils expressed the osteoclastogenic factors RANKL and ADAM-8, thereby augmenting intraarticular osteoclastogenesis in Il1rn and Ccr2-double-deficient mice. …
  • NAID 120002754103


Receptor activator of nuclear factor kappa-B ligand (RANKL), also known as tumor necrosis factor ligand superfamily member 11 (TNFSF11), TNF-related activation- induced cytokine (TRANCE), osteoprotegerin ligand (OPGL), and osteoclast ...


ligand in this instance is called rankl  を調整するRANKL-RANKシグナル系Unfortunately we are unable to provide Unfortunately we are unable to provide Figure 1.Figure 1 Binding of RANKL to RANK

リンク元破骨細胞分化因子」「osteoclast differentiation factor」「receptor activator of NF-kappaB ligand



osteoclast differentiation factorreceptor activator of NF-kappaB ligandRANKL
receptor activator for nuclear factor kB ligand

osteoclast differentiation factor」


osteoprotegerin ligandRANK ligandRANKLreceptor activator of NF-kappaB ligand

receptor activator of NF-kappaB ligand」



osteoclast differentiation factorRANKL



receptor activator of nuclear factor-kappa B、receptor activator of nuclear factor-kappaB
receptor activator for nuclear factor kB

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