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  • Apoptotic and stress signaling markers are augmented in preeclamptic placenta and umbilical cord.
  • Afroze SH1, Kalagiri RR2, Reyes M3, Zimmerman JD3, Beeram MR2, Drever N3, Zawieja DC1, Kuehl TJ4, Uddin MN5.
  • BBA clinical.BBA Clin.2016 May 25;6:25-30. doi: 10.1016/j.bbacli.2016.05.003. eCollection 2016.
  • OBJECTIVE: Preeclampsia (preE) has a significant link to alterations of placental function leading to stress and apoptotic signaling, which pass the placental barrier and leave persistent defect in the circulation of the offspring. We assessed apoptotic signaling in placentas and umbilical cords fro
  • PMID 27335802
  • PET imaging of cyclooxygenase-2 (COX-2) in a pre-clinical colorectal cancer model.
  • Tietz O1, Wuest M1, Marshall A1, Glubrecht D1, Hamann I1, Wang M1, Bergman C1, Way JD1, Wuest F2,3.
  • EJNMMI research.EJNMMI Res.2016 Dec;6(1):37. doi: 10.1186/s13550-016-0192-9. Epub 2016 Apr 26.
  • BACKGROUND: Cyclooxygenase-2 (COX-2) is the inducible isoform of the cyclooxygenase enzyme family. COX-2 is involved in tumor development and progression, and frequent overexpression of COX-2 in a variety of human cancers has made COX-2 an important drug target for cancer treatment. Non-invasive ima
  • PMID 27112768
  • Characterization and functional analysis of toll-like receptor 4 in Chinese soft-shelled turtle Pelodiscus sinensis.
  • Zhou Y1, Liang Q2, Li W2, Gu Y1, Liao X1, Fang W1, Li X3.
  • Developmental and comparative immunology.Dev Comp Immunol.2016 Oct;63:128-35. doi: 10.1016/j.dci.2016.05.023. Epub 2016 Jun 1.
  • Mammalian Toll-like receptor 4 (TLR4) recognizes lipopolysaccharide (LPS) in initiating the innate immune responses. Early studies indicate that turtles are more resistant to LPS challenge than mammals. It remains unknown if turtles express TLR4 and why they are more resistant to LPS. In this study,
  • PMID 27259833


  • Effect of Steroids on HOXA10 mRNA and Protein Expression and Prostaglandin Production in the Porcine Endometrium
  • BLITEK Agnieszka,KIEWISZ Jolanta,WACLAWIK Agnieszka,KACZMAREK Monika M.,ZIECIK Adam J.
  • The Journal of reproduction and development 56(6), 643-648, 2010-12-01
  • NAID 10027730375
  • Effect of Steroids on HOXA10 mRNA and Protein Expression and Prostaglandin Production in the Porcine Endometrium
  • Blitek Agnieszka,Kiewisz Jolanta,Waclawik Agnieszka [他],KACZMAREK Monika M.,ZIECIK Adam J.
  • Journal of Reproduction and Development 56(6), 643-648, 2010
  • … Moreover, HOXA10-dependent expression of prostaglandin H synthase-2 (PGHS-2), a key enzyme in prostaglandin production, has been previously detected. …
  • NAID 130000329055
  • Enhanced Release of Prostaglandin D_2 during Re-incubation of RAW 264.7 Macrophage-Like Cells after Treatment of Both Lipopolysaccharide and Non-steroidal Anti-inflammatory Drugs(Biochemistry/Molecular Biology)
  • Tanaka Yasuhito,Takizawa Makiko,Igimi Shizunobu [他],AMANO Fumio
  • Biological & pharmaceutical bulletin 27(7), 985-991, 2004-07-01
  • … RAW 264.7 macrophage-like cells are known to release prostaglandins (PCs), mainly PGD_2 to the culture medium after lipopolysaccharide (LPS)-treatment. … This release was inhibited by non-steroidal anti-inflammatory drugs (NSAIDs), which are known to inhibit prostaglandin H_2 synthase (PGHS) activity. … In this study, we examined the effect of removal of NSAID after induction of PGHS with LPS, on the release of PCs, which has not been studied well. …
  • NAID 110003608900


It has been found that human PGHS-2 functions as a conformational heterodimer having a catalytic monomer (E-cat) and an allosteric monomer (E-allo). Heme binds only to the peroxidase site of E-cat while substrates, as well as certain ...







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See Prostaglandin H synthase

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