出典: meddic

非ヌクレオシド系逆転写酵素阻害薬 nonnucleoside reverse transcriptase inhibitor

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/09/07 04:22:51」(JST)

wiki en

[Wiki en表示]

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.


  • A qualitative PCR minipool strategy to screen for virologic failure and antiretroviral drug resistance in South African patients on first-line antiretroviral therapy.
  • Newman H1, Breunig L2, van Zyl G3, Stich A4, Preiser W3.
  • Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology.J Clin Virol.2014 Aug;60(4):387-91. doi: 10.1016/j.jcv.2014.05.011. Epub 2014 May 29.
  • BACKGROUND: The high cost of commercial HIV-1 viral load tests for monitoring of patients on antiretroviral treatment limits their use in resource-constrained settings. Commercial genotypic antiretroviral resistance testing is even more costly, yet it provides important benefits.OBJECTIVES: We sough
  • PMID 24929754
  • E138A in HIV-1 reverse transcriptase is more common in subtype C than B: Implications for rilpivirine use in resource-limited settings.
  • Sluis-Cremer N1, Jordan MR2, Huber K3, Wallis CL4, Bertagnolio S5, Mellors JW3, Parkin NT6, Richard Harrigan P7.
  • Antiviral research.Antiviral Res.2014 Jul;107:31-4. doi: 10.1016/j.antiviral.2014.04.001. Epub 2014 Apr 16.
  • The nonnucleoside reverse transcriptase (RT) inhibitor rilpivirine (RPV) has been co-formulated with emtricitabine and tenofovir disoproxil fumarate for initial therapy of HIV-1-infected individuals. RPV, formulated as a long-acting nanosuspension, will also be assessed for its ability to prevent HI
  • PMID 24746459
  • A mechanistic and structural investigation of modified derivatives of the diaryltriazine class of NNRTIs targeting HIV-1 reverse transcriptase.
  • Mislak AC1, Frey KM1, Bollini M2, Jorgensen WL2, Anderson KS3.
  • Biochimica et biophysica acta.Biochim Biophys Acta.2014 Jul;1840(7):2203-11. doi: 10.1016/j.bbagen.2014.04.001. Epub 2014 Apr 12.
  • BACKGROUND: Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are vital in treating HIV-1 infection by inhibiting reverse transcriptase (RT). Drug toxicity and resistance drive the need for effective new inhibitors with improved physiochemical properties and potent antiviral activity. Compute
  • PMID 24726448


  • 非ヌクレオシド系逆転写酵素阻害剤RPV(エジュラント®錠 25 mg)の薬理学的特徴および臨床試験成績
  • 岩田 理子,敷波 幸治,梛野 健司,原田 寧
  • 日本薬理学雑誌 141(4), 205-211, 2013
  • … 剤(NNRTI)で,野生型(WT)および既存のNNRTIに耐性のヒト免疫不全ウイルス(HIV)に対して強力な抗ウイルス作用を持つ.RPVは標的となる逆転写酵素(RT)のNNRTI結合ポケットに深く結合するとともに,柔軟な立体構造特性で変異によるNNRTI結合ポケットの構造変化にも適応する.In vitroでの検討から,RPVは耐性を引き起こしにくく,NNRTI関 …
  • NAID 130003362552
  • 病気について知りたい! 臨床講座(41)HIV感染症
  • 宮川 寿一,満屋 裕明
  • Pharma tribune : なりたい薬剤師になる! 4(5), 61-72, 2012-05-00
  • NAID 40019329987
  • 診断と治療のTopics 新規NNRTIの位置付け
  • 潟永 博之
  • HIV感染症とAIDSの治療 3(2), 23-29, 2012-00-00
  • NAID 40019534471


最近の新薬や添付文書改訂の中から、週に1回、必ず押さえておきたい注目情報をピックアップしてお届けします。(協力:慈恵医大病院薬剤部) 2012年6月8日、抗ウイルス化学療法薬のリルピビリン塩酸塩(RPV:商品名エジュラント錠 ...
非核酸系逆転写酵素阻害剤(NNRTI=Non-Nucleoside Reverse Transcriptase Inhibitor)も、その名が示すとおり逆転写酵素を阻害する薬剤である。現在、以下の4薬剤が認可されているが、わが国ではEFVが群を抜いて多く使用されている。
nnrti noun an antiviral drug used against HIV; binds directly to reverse transcriptase and prevents RNA conversion to DNA; often used in combination with other drugs [syn: non-nucleoside reverse transcriptase inhibitor] WordNet® 3 ...


Figure 1. NNRTI Mechanism of Action and Fig. 3. NNRTI-binding seizes Fig. 1.Index of /cop/762Mode of Action - NNRTI RT inhibitor (NNRTI)-resistance mutations

リンク元非核酸系逆転写酵素阻害薬」「nonnucleoside reverse transcriptase inhibitor


  [★] 非核酸系逆転写酵素阻害薬



nonnucleoside reverse transcriptase inhibitor, NNRTI
[show details]

nonnucleoside reverse transcriptase inhibitor」

  [★] 非ヌクレオシド系逆転写酵素阻害薬 NNRTI



Non-nucleoside reverse transcriptase inhibitors
non-nucleoside reverse transcriptase inhibibors

"http://meddic.jp/NNRTI" より作成