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the 14th letter of the Roman alphabet (同)n

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nitrogenの化学記号
neodymiumの化学記号

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/01/16 16:11:14」(JST)

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Methylscopolamine or methscopolamine, usually provided as the bromide salt (trade name Pamine), is an oral medication used along with other medications to treat peptic ulcers by reducing stomach acid secretion.^[1] Proton pump inhibitors and antihistamine medications have made this use obsolete. It can also be used for stomach or intestinal spasms, to reduce salivation, and to treat motion sickness. Methscopolamine is also commonly used as a drying agent, to dry up post-nasal drip, in cold, irritable bowel syndrome and allergy medications (trade names Extendryl, AlleRx, Rescon).

Methscopolamine, a methylated derivative of scopolamine, is a muscarinic antagonist structurally similar to the neurotransmitter acetylcholine. Its mechanism of action involves blocking the muscarinic acetylcholine receptors.

References

^ Drugs.com: Methscopolamine

This drug article relating to the gastrointestinal system is a stub. You can help Wikipedia by expanding it.

English Journal

Altered trafficking and unfolded protein response induction as a result of M3 muscarinic receptor impaired N-glycosylation.

Romero-Fernandez W, Borroto-Escuela DO, Perez Alea M, Garcia-Mesa Y, Garriga P.SourceCentre de Biotecnologia Molecular, Department d'Enginyeria Quimica, Universitat Politecnica de Catalunya, Spain. Email: (WRF) wilber.romero@upc.edu, (PG) pere.garriga@upc.edu.
Glycobiology.Glycobiology.2011 Jul 28. [Epub ahead of print]
The human M(3) muscarinic acetylcholine receptor is present in both the central and peripheral nervous system, and it is involved in the pathophysiology of several neurodegenerative and autoimmune diseases. We suggested a possible N-glycosylation map for M(3) muscarinic receptor expressed in COS-7 c
PMID 21798865

Influence of tissue integrity on pharmacological phenotypes of muscarinic acetylcholine receptors in the rat cerebral cortex.

Anisuzzaman AS, Nishimune A, Yoshiki H, Uwada J, Muramatsu I.SourceDivision of Pharmacology, Department of Biochemistry and Bioinformative Sciences, School of Medicine.
The Journal of pharmacology and experimental therapeutics.J Pharmacol Exp Ther.2011 Jun 30. [Epub ahead of print]
Distinct pharmacological phenotypes of muscarinic acetylcholine receptors (mAChRs) have been proposed. We compared the pharmacological profiles of mAChRs in intact segments and homogenates of rat cerebral cortex and other tissues by using radioligand binding assays with [(3)H]N-methylscopolamine ([(
PMID 21719469

Japanese Journal

Assessment of Novel Muscarinic Acetylcholine Receptors in Rat Cerebral Cortex by a Tissue Segment Binding Method

LEE Kung-Shing,NISHIMUNE Atsushi,YOSHIKI Hatsumi,ANISUZZAMAN Abu Syed Md,SUZUKI Fumiko,WANG Mao-Hsien,CHENG Juei-Tang,MURAMATSU Ikunobu
Journal of pharmacological sciences 112(4), 444-451, 2010-04-20
… These mAChRs were a mixture of high- and low-affinity sites for N-methylscopolamine (NMS) in a 70:30 ratio. …
NAID 10027909139

Pharmacologically Relevant Receptor Binding Characteristics and 5α-Reductase Inhibitory Activity of Free Fatty Acids Contained in Saw Palmetto Extract(Pharmacology)

ABE Masayuki,ITO Yoshihiko,OYUNZUL Luvsandorj,OKI-FUJINO Tomomi,YAMADA Shizuo
Biological & pharmaceutical bulletin 32(4), 646-650, 2009-04-01
… Also, lauric acid, oleic acid, myristic acid and linoleic acid inhibited specific [^3H]N-methylscopolamine ([^3H]NMS) binding in rat brain with IC_<50> …
NAID 110007160688

Related Pictures

★リンクテーブル★

リンク元	「N-メチルスコポラミン」
拡張検索	「N-methylscopolamine methylsulfate」
関連記事	「n」「N」「methylscopolamine」「Nd」

「N-メチルスコポラミン」

Methylscopolamine bromide
Systematic (IUPAC) name
	(1R,2S,4R,5S,7R)-{[(2R)-3-hydroxy-2-phenylpropanoyl]oxy}-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonane
Clinical data
Trade names	Pamine, Extendryl, AlleRx, Rescon
AHFS/Drugs.com	monograph
MedlinePlus	a606008
Pharmacokinetic data
Biological half-life	3–4 hrs
Identifiers
CAS Number	155-41-9
ATC code	A03BB03 S01FA03
PubChem	CID: 441342
DrugBank	DB00462
ChemSpider	21106347
UNII	RTN51LK7WL
ChEMBL	CHEMBL376897
Chemical data
Formula	C18H24NO4
Molecular mass	318.388 g/mol
	SMILES OC[C@H](c1ccccc1)C(=O)O[C@H]2C[C@@H]3[N+](C)(C)[C@H](C2)[C@H]4O[C@@H]34 ;
	InChI InChI=1S/C18H24NO4/c1-19(2)14-8-12(9-15(19)17-16(14)23-17)22-18(21)13(10-20)11-6-4-3-5-7-11/h3-7,12-17,20H,8-10H2,1-2H3/q+1/t12-,13-,14-,15+,16-,17+/m1/s1 ; Key:LZCOQTDXKCNBEE-IKIFYQGPSA-N ;
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