WordNet

talk frankly with; lay it on the line; "I have to level with you"
become level or even; "The ground levelled off" (同)level off
indicator that establishes the horizontal when a bubble is centered in a tube of liquid (同)spirit_level
height above ground; "the water reached ankle level"; "the pictures were at the same level"
an abstract place usually conceived as having depth; "a good actor communicates on several levels"; "a simile has at least two layers of meaning"; "the mind functions on many strata simultaneously" (同)layer, stratum
tear down so as to make flat with the ground; "The building was levelled" (同)raze, rase, dismantle, tear down, take_down, pull down
not showing abrupt variations; "spoke in a level voice"; "she gave him a level look"- Louis Auchincloss (同)unwavering
aim at; "level criticism or charges at somebody"
being on a precise horizontal plane; "a billiard table must be level"
oriented at right angles to the plumb; "the picture is level"
the 12th letter of the Roman alphabet (同)l
the basic unit of money in Bulgaria

PrepTutorEJDIC

(土地などが)『平らな』,水平な,凸凹のない / 『同じ高さ(程度)の』 / 《話》精神状態がよくつり合いのとれた,分別のある / 〈U〉〈C〉(地位・程度などの一般的な)『標準』,『水準』,レベル / 〈C〉(高さ・深さの基準となる)『水平面』,水平線 / 〈C〉〈U〉(ある物と比べたときの)『高さ』,深さ / 〈C〉(建物の)階,層 / 〈C〉《おもに米》(水準器《英》spirit level) / 〈物の表面〉‘を'『平らにする』 / 〈木・家など〉‘を'倒す / 〈地位・程度など〉‘を'一様にする,平均する / 《『level』+『名』+『at』+『名』》(目標に)〈銃など〉の水準器を合わせる / 《『level』+『名』+『at』(『against』)+『名』〈人〉》(人に)〈非難など〉‘を'浴びせる / 水平に,平らに
lira(イタリアの貨幣単位リラ)

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1. 月経周期の評価と排卵時期 evaluation of the menstrual cycle and timing of ovulation
2. 成人における多嚢胞性卵巣症候群の臨床症状 clinical manifestations of polycystic ovary syndrome in adults
3. 正常月経周期の生理学 physiology of the normal menstrual cycle
4. 男性における原発性性腺機能低下の原因 causes of primary hypogonadism in males
5. ゴナドトロピン産生下垂体腺腫，およびその他の臨床的に非機能性の下垂体腺腫の臨床症状および診断 clinical manifestations and diagnosis of gonadotroph and other clinically nonfunctioning pituitary adenomas

English Journal

Dietary cholesterol and oxidised cholesterol: effects on sperm characteristics, antioxidant status and hormonal profile in rats.

Khorrami A1, Ghanbarzadeh S, Ziaee M, Arami S, Vajdi R, Garjani A.Author information 1Department of Pharmacology and Toxicology, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran; Student Research Committee, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.AbstractPresent study was designed to compare the potential effects of high serum levels of LDL and oxidised LDL (OxLDL) on spermatogenesis parameters in male Wistar rats. Animals were allocated into three groups and were fed for 14 weeks with normal, cholesterol-rich and oxidised cholesterol-rich diets. Blood lipid profile, sex hormones level, as well as sex organs weight were evaluated. The sex organs weight in oxidised cholesterol-fed group was significantly reduced (P < 0.05). Spermatozoa count in the group with high serum concentration of OxLDL (64 ± 4.2 × 106 ) was markedly lower (P < 0.01) than that of normal rats (87 ± 4.1 × 106 ) and rats with high serum level of LDL (90 ± 6.3 × 106 ). Similarly, the percentage of viable spermatozoa was significantly (P < 0.001) decreased from 78% to 52% by high level of OxLDL in serum. While, nonoxidised LDL did not have suppressive effects on spermatogenesis and organs weight. Consistent with these effects, the serum concentration of sex hormones including FSH (P < 0.001), LH (P < 0.001) and testosterone (P < 0.01) was significantly decreased only in rats with high level of OxLDL but not in rats with high level of nonoxidised LDL. In conclusion, high OxLDL level showed higher destructive effect on reproductive system compared to the high LDL level.
Andrologia.Andrologia.2014 Mar 12. doi: 10.1111/and.12262. [Epub ahead of print]
Present study was designed to compare the potential effects of high serum levels of LDL and oxidised LDL (OxLDL) on spermatogenesis parameters in male Wistar rats. Animals were allocated into three groups and were fed for 14 weeks with normal, cholesterol-rich and oxidised cholesterol-rich diets. B
PMID 24620776

The kisspeptin-GnRH pathway in human reproductive health and disease.

Skorupskaite K1, George JT, Anderson RA.Author information 1MRC Centre for Reproductive Health, The Queen's Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK.AbstractBACKGROUNDThe discovery of kisspeptin as key central regulator of GnRH secretion has led to a new level of understanding of the neuroendocrine regulation of human reproduction. The related discovery of the kisspeptin-neurokinin B-dynorphin (KNDy) pathway in the last decade has further strengthened our understanding of the modulation of GnRH secretion by endocrine, metabolic and environmental inputs. In this review, we summarize current understanding of the physiological roles of these novel neuropeptides, and discuss the clinical relevance of these discoveries and their potential translational applications.METHODSA systematic literature search was performed using PUBMED for all English language articles up to January 2014. In addition, the reference lists of all relevant original research articles and reviews were examined. This review focuses mainly on published human studies but also draws on relevant animal data.RESULTSKisspeptin is a principal regulator of the secretion of gonadotrophins, and through this key role it is critical for the onset of puberty, the regulation of sex steroid-mediated feedback and the control of adult fertility. Although there is some sexual dimorphism, both neuroanatomically and functionally, these functions are apparent in both men and women. Kisspeptin acts upstream of GnRH and, following paracrine stimulatory and inhibitory inputs from neurokinin B and dynorphin (KNDy neuropeptides), signals directly to GnRH neurones to control pulsatile GnRH release. When administered to humans in different isoforms, routes and doses, kisspeptin robustly stimulates LH secretion and LH pulse frequency. Manipulation of the KNDy system is currently the focus of translational research with the possibility of future clinical application to regulate LH pulsatility, increasing gonadal sex steroid secretion in reproductive disorders characterized by decreased LH pulsatility, including hypothalamic amenorrhoea and hypogonadotropic hypogonadism. Conversely there may be scope to reduce the activity of the KNDy system to reduce LH secretion where hypersecretion of LH adds to the phenotype, such as in polycystic ovary syndrome.CONCLUSIONSKisspeptin is a recently discovered neuromodulator that controls GnRH secretion mediating endocrine and metabolic inputs to the regulation of human reproduction. Manipulation of kisspeptin signalling has the potential for novel therapies in patients with pathologically low or high LH pulsatility.
Human reproduction update.Hum Reprod Update.2014 Mar 9. [Epub ahead of print]
BACKGROUNDThe discovery of kisspeptin as key central regulator of GnRH secretion has led to a new level of understanding of the neuroendocrine regulation of human reproduction. The related discovery of the kisspeptin-neurokinin B-dynorphin (KNDy) pathway in the last decade has further strengthened o
PMID 24615662

Knockdown of CEBPβ by RNAi in porcine granulosa cells resulted in S phase cell cycle arrest and decreased progesterone and estradiol synthesis.

Zhen YH1, Wang L1, Riaz H1, Wu JB1, Yuan YF1, Han L2, Wang YL1, Zhao Y1, Dan Y1, Huo LJ3.Author information 1Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction, Education Ministry of China, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan 430070, Hubei, People's Republic of China.2College of Animal Sciences & Techology/College of Vererinary Medicine, Huazhong Agricultural University, Wuhan 430070, People's Republic of China.3Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction, Education Ministry of China, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan 430070, Hubei, People's Republic of China. Electronic address: lijunhuo@yahoo.com.AbstractCultured ovarian granulosa cells (GCs) are essential models to study molecular mechanisms of gene regulation during folliculogenesis. CCAAT enhancer binding proteins β (CEBPβ) has been identified in the ovary and is critical for follicular growth, ovulation and luteinization in mice. In the present study, hormonal treatment indicated that luteinizing hormone (LH) and exogenous human chorionic gonadotropins (hCG) significantly increased the expression of CEBPβ in porcine GCs. By RNAi-Ready pSIREN-RetroQ-ZsGreen Vector mediated recombinant pshRNA vectors, CEBPβ gene was successfully knocked down in porcine GCs, confirmed by mRNA and protein level analyzed by real time PCR and western blot, respectively. We further found that knockdown of CEBPβ significantly increased the expression of p-ERK1/2. Furthermore, CEBPβ knockdown arrested the GCs at S phase of cell cycle, but had no effects on cell apoptosis. More importantly, it markedly down regulated the concentration of estradiol (E2) and progesterone (P4) in the culture medium. To uncover the regulatory mechanism of CEBPβ knockdown on cell cycle and steroids synthesis, we found that the mRNA expression of bcl-2 (anti-apoptosis), StAR and Runx2 (steroid hormone synthesis) was up-regulated, while genes related to apoptosis (Caspase-3 and p53), hormonal synthesis (CYP11A1) and cell cycle (cyclinA1, cyclinB1, cyclinD1) were down-regulated, suggesting that knockdown of CEBPβ may inhibit apoptosis, regulate cell cycle and hormone secretions at the transcriptional level in porcine GCs. Furthermore, knockdown of CEBPβ significantly increased the expression of PTGS2 and decreased the expression of IGFBP4, Has2 and PTGFR which are important for folliculogenesis in porcine GCs. In conclusion, this study reveals that CEBPβ is a key regulator of porcine GCs through modulation of cell cycle, apoptosis, steroid synthesis, and other regulators of folliculogenesis.
The Journal of steroid biochemistry and molecular biology.J Steroid Biochem Mol Biol.2014 Mar 4. pii: S0960-0760(14)00042-9. doi: 10.1016/j.jsbmb.2014.02.013. [Epub ahead of print]
Cultured ovarian granulosa cells (GCs) are essential models to study molecular mechanisms of gene regulation during folliculogenesis. CCAAT enhancer binding proteins β (CEBPβ) has been identified in the ovary and is critical for follicular growth, ovulation and luteinization in mice. In the presen
PMID 24607812