HTLV-I

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ヒトT細胞白血病ウイルス1型, HTLV-1

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/05/24 01:40:10」(JST)

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英文文献

  • Serum IgA level, monocyte count, and international prognostic index are independently associated with overall survival in patients with HTLV-I-negative nodal peripheral T cell lymphoma.
  • Kato A1, Imai Y, Aoki K, Tabata S, Matsushita A, Hashimoto H, Takahashi T, Ishikawa T.Author information 1Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan, aikokato@kuhp.kyoto-u.ac.jp.AbstractPeripheral T cell lymphomas (PTCL) account for 10-15 % of non-Hodgkin's lymphomas and are associated with poor prognosis. Although many prognostic factors for PTCL have been proposed, the heterogeneity of PTCL seems to be an obstacle in the establishment of clinically useful prognostic system, such as the International Prognostic Index (IPI) in diffuse large B cell lymphoma. PTCL with nodal manifestation include the HTLV-I-negative histologic subtypes of PTCL not otherwise specified (PTCL-NOS), angioimmunoblastic T cell lymphoma (AITL), and anaplastic large cell lymphoma (ALCL). As PTCL-NOS encompasses a group of similar tumors and mostly shares their clinical pictures, we retrospectively analyzed clinical data from 77 patients diagnosed with ALCL, AITL, and PTCL-NOS at Kobe City Medical Center General Hospital from May 1994 to February 2012 to identify the prognostic factor for nodal PTCL. The median age of patients was 64 years, ranging from 23 to 83 years. With a median follow-up of 50 months, 5-year overall survival (OS) was 43 %. Multivariate analysis identified high-risk IPI (hazard ratio (HR), 4.04; P = 0.015), absolute monocyte count > 0.8 × 109/L (HR, 3.44; P = 0.001), and serum concentration of IgA > 410 mg/dL (HR, 2.31; P = 0.013) as poor prognostic factors for OS. Thus, we have identified novel prognostic factors of monocyte count and serum IgA level for nodal PTCL. Although conventional prognostic models mainly reflect both tumor characteristics and host factors, the present model indicates the importance of host immune response as the unfavorable prognosis.
  • Annals of hematology.Ann Hematol.2014 Feb 14. [Epub ahead of print]
  • Peripheral T cell lymphomas (PTCL) account for 10-15 % of non-Hodgkin's lymphomas and are associated with poor prognosis. Although many prognostic factors for PTCL have been proposed, the heterogeneity of PTCL seems to be an obstacle in the establishment of clinically useful prognostic system, such
  • PMID 24526138
  • Microenvironment of adult T-cell leukemia/lymphoma-associated nodal lesions.
  • Ohshima K1, Niino D, Karube K.Author information 1Department of Pathology, School of Medicine, Kurume University, Asahimati 67, Kurume, 830-0011, Japan, ohshima_kouichi@med.kurume-u.ac.jp.AbstractAdult T-cell leukemia/lymphoma (ATLL) is a human malignancy associated with the retrovirus, human T-cell leukemia virus type I (HTLV-I). In a previous series of studies, our group and others characterized the histopathological changes in HTLV-I-associated lymph node lesions. In addition to the pleomorphic and anaplastic large cell types of typical ATL lymphoma, we identified lymph nodes with an unusual Hodgkin's disease-like histology (Hodgkin-like ATLL) in HTLV-I-positive patients, with Hodgkin-like ATLL showing prodromal clinical features. We also reported HTLV-I-associated lymphadenitis, characterized by non-neoplastic HTLV-I-associated lymph node lesions. It has become clear that the biological and clinical behavior of malignant lymphoma is not only determined by the properties of the lymphoma cells themselves, but also largely by the interaction of these cells with their nonmalignant microenvironment. In this review, we discuss the pathological variations of microenvironments, which are important for clarification of the histological features associated with HTLV-I.
  • International journal of hematology.Int J Hematol.2014 Jan 31. [Epub ahead of print]
  • Adult T-cell leukemia/lymphoma (ATLL) is a human malignancy associated with the retrovirus, human T-cell leukemia virus type I (HTLV-I). In a previous series of studies, our group and others characterized the histopathological changes in HTLV-I-associated lymph node lesions. In addition to the pleom
  • PMID 24481941
  • KSHV vCyclin counters the senescence/G1 arrest response triggered by NF-κB hyperactivation.
  • Zhi H, Zahoor MA, Shudofsky AM, Giam CZ.Author information Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.AbstractMany oncogenic viruses activate nuclear factor-κB (NF-κB) as a part of their replicative cycles. We have shown recently that persistent and potentially oncogenic activation of NF-κB by the human T-lymphotropic virus 1 (HTLV-1) oncoprotein Tax immediately triggers a host senescence response mediated by cyclin-dependent kinase inhibitors: p21CIP1/WAF1 (p21) and p27Kip1 (p27) Here we demonstrate that RelA/NF-κB activation by Kaposi sarcoma herpesvirus (KSHV) latency protein vFLIP also leads to p21/p27 upregulation and G1 cell cycle arrest. Remarkably, KSHV vCyclin, another latency protein coexpressed with vFLIP from a bicistronic latency-specific mRNA, was found to prevent the senescence and G1 arrest induced by HTLV-1 Tax and vFLIP, respectively. This is because of the known ability of vCyclin/cyclin-dependent kinase 6 complex to resist p21 and p27 inhibition and cause p27 degradation. In KSHV-transformed BCBL-1 cells, sustained vFLIP expression with small hairpin RNAs-mediated vCyclin depletion resulted in G1 arrest. The functional interdependence of vFLIP and vCyclin explains why they are cotranslated from the same viral mRNA. Importantly, deregulation of the G1 cyclin-dependent kinase can facilitate chronic I-κB kinases/NF-κB activation.Oncogene advance online publication, 27 January 2014; doi:10.1038/onc.2013.567.
  • Oncogene.Oncogene.2014 Jan 27. doi: 10.1038/onc.2013.567. [Epub ahead of print]
  • Many oncogenic viruses activate nuclear factor-κB (NF-κB) as a part of their replicative cycles. We have shown recently that persistent and potentially oncogenic activation of NF-κB by the human T-lymphotropic virus 1 (HTLV-1) oncoprotein Tax immediately triggers a host senescence response mediat
  • PMID 24469036

和文文献

  • オステオポンチンは成人T細胞白血病リンパ腫(ATL)の予後因子である (AYUMI 細胞外マトリックス中の異端児matricellular protein : 疾患病態の制御因子であり治療の標的分子)
  • 服部 俊夫,浩 日勒
  • 医学のあゆみ 248(7), 543-547, 2014-02-15
  • NAID 40019977441
  • HTLV-I感染拡大阻止に有効なワクチンと抗体医薬に関する研究 (特集 ATL/HTLV-1研究の最近の進展)
  • HTLV-I母子感染対策事業における保健師の役割 : 長崎県における取り組みを中心に (特集 母子保健のバージョンアップ)
  • 増﨑 英明
  • 保健師ジャーナル 69(10), 795-800, 2013-10
  • NAID 40019810277

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HTLV-1について紹介しています。 ... PDFファイルを見るためには、Adobe Readerというソフトが必要です。Adobe Readerは無料で配布されていますので、左記のアイコンをクリックしてダウンロードしてください。
Q:免疫が心配なので、初乳だけでも与えることはできませんか? A:3ヶ月以内短期母乳保育での母子感染率は厚生労働科研研究班のデータでは1.9%ですが、初乳のみのデータはありません。少なくともこれ以上になることはないと ...

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★リンクテーブル★
先読みヒトT細胞白血病ウイルス1型」「HTLV-1
国試過去問095B072」「089A051」「087B071
拡張検索HTLV-I脊髄症」「HTLV-I関連関節症」「HTLV-I母子感染
関連記事I」「HT」「Id」「HTLV

ヒトT細胞白血病ウイルス1型」

  [★]

human T-cell leukemia virus type 1, human T-cell leukemia virus-1, HTLV-1
成人Tリンパ球向性ウイルス1、ヒトTリンパ好性ウイルス1、成人T細胞白血病ウイルス1型ヒトTリンパ好性ウイルス1型ヒトTリンパ球向性ウイルス1型、human T lymphotropic virus-1 human T-lymphotropic virus-1, human T-cell lymphotropic virus type 1, human T-cell lymphotropic viruses type I, human T lymphotropic virus type 1
成人T細胞白血病ヒトT細胞白血病ウイルス
[show details]

ウイルス学

感染症


HTLV-1」

  [★] ヒトT細胞白血病ウイルス1型


095B072」

  [★]

[正答]


※国試ナビ4※ 095B071]←[国試_095]→[095B073

089A051」

  [★]

  • 母子感染について誤っている組み合わせはどれか

087B071」

  [★]

  • 疾患と原因の組み合わせで間違っている物

HTLV-I脊髄症」

  [★]

HTLV-I-associated myelopathy
熱帯性痙性不全対麻痺症HTLV-I関連脊髄症ヒトTリンパ好性ウイルスI型関連脊髄症HTLV-I型関連ミエロパシー

HTLV-I関連関節症」

  [★]

HTLV-I associated arthropathy HAAP


HTLV-I母子感染」

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HTLV-I mother-infant infection


I」

  [★]

WordNet   license wordnet

「the 9th letter of the Roman alphabet」
i

PrepTutorEJDIC   license prepejdic

「『私は』私が」

PrepTutorEJDIC   license prepejdic

「iodineの化学記号」

HT」

  [★]

Id」

  [★]


HTLV」

  [★] ヒトTリンパ球向性ウイルス


"http://meddic.jp/HTLV-I" より作成


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