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  • Insights into the poor prognosis of allopurinol-induced severe cutaneous adverse reactions: the impact of renal insufficiency, high plasma levels of oxypurinol and granulysin.
  • Chung WH1, Chang WC2, Stocker SL3, Juo CG4, Graham GG3, Lee MH3, Williams KM3, Tian YC5, Juan KC5, Jan Wu YJ6, Yang CH7, Chang CJ8, Lin YJ8, Day RO3, Hung SI2.
  • Annals of the rheumatic diseases.Ann Rheum Dis.2015 Dec;74(12):2157-64. doi: 10.1136/annrheumdis-2014-205577. Epub 2014 Aug 12.
  • OBJECTIVE: Allopurinol, an antihyperuricaemic agent, is one of the common causes of life-threatening severe cutaneous adverse reactions (SCAR), including drug rash with eosinophilia and systemic symptoms (DRESS), Stevens-Johnson syndrome (SJS) and toxic epidermal necrosis (TEN). The prognostic facto
  • PMID 25115449
  • Evaluation of Cytokine Profile and HLA Association in Benznidazole Related Cutaneous Reactions in Patients With Chagas Disease.
  • Salvador F1, Sánchez-Montalvá A1, Martínez-Gallo M2, Sala-Cunill A3, Viñas L2, García-Prat M2, Aparicio G4, Sao Avilés A1, Artaza MÁ5, Ferrer B6, Molina I1.
  • Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.Clin Infect Dis.2015 Dec 1;61(11):1688-94. doi: 10.1093/cid/civ690. Epub 2015 Aug 11.
  • BACKGROUND: Benznidazole is the drug of choice for Chagas disease. The major drawback of this drug is the high adverse events rate, being cutaneous reactions the most frequent one, leading to definitive withdrawal of treatment in 15%-30% of patients.METHODS: Prospective observational study where adu
  • PMID 26265500
  • Genetic screening for human leukocyte antigen alleles prior to carbamazepine treatment.
  • Tan JC1, Murrell DF2, Hersch MI3.
  • Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia.J Clin Neurosci.2015 Dec;22(12):1992-3. doi: 10.1016/j.jocn.2015.05.037. Epub 2015 Aug 28.
  • We describe a 28-year-old Malaysian Australian man of Han Chinese descent with toxic epidermal necrolysis (TEN), occurring 2weeks after commencing carbamazepine. He was subsequently found to be positive for human leukocyte antigen (HLA)-B*1502. Carbamazepine-induced Stevens-Johnson syndrome/TEN is s
  • PMID 26319500


  • CLINICAL INVESTIGATION : Treatment of recurrent anterior uveitis with infliximab in patient with ankylosing spondylitis
  • Matsuda Junko,Kaburaki Toshikatsu,Kobayashi Shigeto
  • Japanese journal of ophthalmology : the official English-language journal of the Japanese Ophthalmological Society 57(1), 104-107, 2013-01
  • NAID 40019546507
  • Cutaneous polyarteritis nodosa associated with HLA-B39-positive undifferentiated spondyloarthritis in a Japanese patient
  • NAKANO Hiromasa,OOKA Seido,SHIBATA Tomohiko,OGAWA Hitoshi,ITO Hiroshi,TAKAKUWA Yukiko,TONOOKA Kumiko,MAEDA Akihiko,YAMASAKI Yoshioki,KIYOKAWA Tomofumi,NAGAFUCHI Hiroko,YAMADA Hidehiro,OZAKI Shoichi
  • Modern rheumatology 22(5), 783-786, 2012-09-01
  • NAID 10031028056
  • 症例報告 アロプリノールによる中毒性表皮壊死症の1例 : 原因成分,発症背景についての検討
  • 眞海 芳史,安田 文世,森 布衣子
  • 臨床皮膚科 66(8), 579-583, 2012-07
  • NAID 40019382083


2012年1月12日 ... あけましておめでとうございます 2012年1月. 2012年1月 1日(日) 00:00 JST. 投稿者: Admin. 2012年も楽しく研究します. HLABメンバー 一同. 記事を友人にメールする 印刷 用ページ ...


HLA-B.pngHLA-B*1502 Detection - High quality HLA-B HLA-B StructureHLA-Bhla b 1502 a and hla b 5801 b http www HLA-B Gene - GeneCards | 1B82 Protein

リンク元HLA-B antigen

HLA-B antigen」





  • HLA-B27は95%前後陽性
  • HLA-B27陽性者が多く、脊椎炎や仙腸関節炎を生じることがある(SOR.228)
  • 脊椎炎合併例では、HLA-B27陽性例が多いとされる(SOR.229)



  • ベーチェット病:相対危険度8。日本でのベーチェット病患者のHLA-B51陽性率は50-60%、正常者のそれは10-15%。



  • Mg2+存在下でC3, B, Dが反応してC3bBbとなり、これがC3転換酵素(C3bBb)あるいはC5転換酵素(C3bBb3b)を形成する。これらはP(properdin)と結合して活性化し、それぞれC3、C5を活性化する

WordNet   license wordnet

「the 2nd letter of the Roman alphabet」

WordNet   license wordnet

「the blood group whose red cells carry the B antigen」
type B, group B



WordNet   license wordnet

「the 8th letter of the Roman alphabet」

PrepTutorEJDIC   license prepejdic


PrepTutorEJDIC   license prepejdic

「鉛筆の硬度 / 《俗》heroin」




  [★] ヒト白血球抗原 human leukocyte antigen

"http://meddic.jp/HLA-B" より作成