Gasser ganglion

出典: meddic

三叉神経節ガッセル神経節

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英文文献

  • GABAergic influence on temporomandibular joint-responsive spinomedullary neurons depends on estrogen status.
  • Tashiro A1, Bereiter DA2, Thompson R2, Nishida Y3.Author information 1Department of Physiology, National Defense Medical College, Namiki 3-2, Tokorozawa City, Saitama 359-8513, Japan. Electronic address: tashiro@ndmc.ac.jp.2Department of Diagnostic and Biological Sciences, University of Minnesota School of Dentistry, Moos Tower 18-214, 515 Delaware Street SE, Minneapolis, MN 55455, USA.3Department of Physiology, National Defense Medical College, Namiki 3-2, Tokorozawa City, Saitama 359-8513, Japan.AbstractSensory input from the temporomandibular joint (TMJ) to neurons in superficial laminae at the spinomedullary (Vc/C1-2) region is strongly influenced by estrogen status. This study determined if GABAergic mechanisms play a role in estrogen modulation of TMJ nociceptive processing in ovariectomized female rats treated with high- (HE) or low-dose (LE) estradiol (E2) for 2days. Superficial laminae neurons were activated by ATP (1mM) injections into the joint space. The selective GABAA receptor antagonist, bicuculline methiodide (BMI, 5 or 50μM, 30μl), applied at the site of recording greatly enhanced the magnitude and duration of ATP-evoked responses in LE rats, but not in units from HE rats. The convergent cutaneous receptive field (RF) area of TMJ neurons was enlarged after BMI in LE but not HE rats, while resting discharge rates were increased after BMI independent of estrogen status. By contrast, the selective GABAA receptor agonist, muscimol (50μM, 30μl), significantly reduced the magnitude and duration of ATP-evoked activity, resting discharge rate, and cutaneous RF area of TMJ neurons in LE and HE rats, whereas lower doses (5μM) affected only units from LE rats. Protein levels of GABAA receptor β3 isoform at the Vc/C1-2 region were similar for HE and LE rats. These results suggest that GABAergic mechanisms contribute significantly to background discharge rates and TMJ-evoked input to superficial laminae neurons at the Vc/C1-2 region. Estrogen status may gate the magnitude of GABAergic influence on TMJ neurons at the earliest stages of nociceptive processing at the spinomedullary region.
  • Neuroscience.Neuroscience.2014 Feb 14;259:53-62. doi: 10.1016/j.neuroscience.2013.11.053. Epub 2013 Dec 4.
  • Sensory input from the temporomandibular joint (TMJ) to neurons in superficial laminae at the spinomedullary (Vc/C1-2) region is strongly influenced by estrogen status. This study determined if GABAergic mechanisms play a role in estrogen modulation of TMJ nociceptive processing in ovariectomized fe
  • PMID 24316475
  • Study of interferon-β antiviral activity against Herpes simplex virus type 1 in neuron-enriched trigeminal ganglia cultures.
  • Low-Calle AM1, Prada-Arismendy J2, Castellanos JE3.Author information 1Grupo de Virologia, Universidad El Bosque, Carrera 9 No. 131 A-02, Edificio de Biblioteca, Laboratorio 205, Bogotá D.C., Colombia. Electronic address: anamalowc@gmail.com.2Grupo de Virologia, Universidad El Bosque, Carrera 9 No. 131 A-02, Edificio de Biblioteca, Laboratorio 205, Bogotá D.C., Colombia. Electronic address: jpradaarismendy@yahoo.es.3Grupo de Virologia, Universidad El Bosque, Carrera 9 No. 131 A-02, Edificio de Biblioteca, Laboratorio 205, Bogotá D.C., Colombia; Grupo de Patogénesis Infecciosa, Facultad de Odontología, Universidad Nacional de Colombia, Carrera 30 No. 45-03, Edificio 210 - Oficina 301, Bogotá D.C., Colombia. Electronic address: jecastellanosp@unal.edu.co.AbstractHerpes simplex virus type 1 (HSV-1) causes a lytic infection in epithelial cells before being captured and moved via retrograde axonal transport to the nuclei of the sensory neurons of the trigeminal ganglion or dorsal root, where it establishes a latent infection. HSV-1 infection induces an antiviral response through the production of Beta Interferon (IFN-β) in infected trigeminal ganglia. The aim of this work was to characterize the response induced by IFN-β in neuron-enriched trigeminal ganglia primary cultures infected with HSV-1. An antiviral effect of IFN-β in these cultures was observed, including reduced viral production and increased cell survival. In contrast, viral infection significantly decreased both double stranded RNA dependent protein kinase (Pkr) transcription and Jak-1 and Stat-1 phosphorylation, suggesting a possible HSV-1 immune evasion mechanism in trigeminal cells. Additionally, HSV-1 infection upregulated Suppressor of Cytokine Signaling-3 (Socs3) mRNA; upregulation of socs3 was inhibited in IFN-β treated cultures. HSV-1 infection increased the number of Socs3 positive cells and modified the intracellular distribution of Socs3 protein, in infected cells. This neuron-enriched trigeminal ganglia culture model could be used to elucidate the HSV-1 viral cycle in sensory neurons and to study cellular antiviral responses and possible viral evasion mechanisms that underlie the choice between viral replication and latency.
  • Virus research.Virus Res.2014 Feb 13;180:49-58. doi: 10.1016/j.virusres.2013.12.022. Epub 2013 Dec 24.
  • Herpes simplex virus type 1 (HSV-1) causes a lytic infection in epithelial cells before being captured and moved via retrograde axonal transport to the nuclei of the sensory neurons of the trigeminal ganglion or dorsal root, where it establishes a latent infection. HSV-1 infection induces an antivir
  • PMID 24374267
  • Migraine with cranial autonomic features following surgically induced post-ganglionic sympathetic lesion.
  • Royce JS, Goadsby PJ.Author information SwedishAmerican Neuro and Headache Center, Rockford, IL, USA.AbstractBACKGROUND: Although not typically considered as part of the clinical phenotype of migraine, cranial autonomic symptoms, such as lacrimation or conjunctival injection, can certainly occur. Their appearance can lead to the common misdiagnosis of sinus headache in clinical practice.
  • Acta neurologica Scandinavica.Acta Neurol Scand.2014 Feb;129(2):e6-8. doi: 10.1111/ane.12170. Epub 2013 Aug 8.
  • BACKGROUND: Although not typically considered as part of the clinical phenotype of migraine, cranial autonomic symptoms, such as lacrimation or conjunctival injection, can certainly occur. Their appearance can lead to the common misdiagnosis of sinus headache in clinical practice.CASE: The patient p
  • PMID 23924392

関連リンク

Gas·ser ganglion (gahsґər) [Johann Laurentius Gasser, Austrian professor, 1725–1765] ganglion trigeminale ... Look at other dictionaries: Gasser-Ganglion — Gạsser Gan|glion [nach dem östr. Anatomen J.Gasser GanglionL.
Medical Definition: Gasser ganglion Trigeminal sensory ganglion. * Automatic translation

関連画像

Gasserian-Ganglion-Block-1Images , behandeling RF ganglion Gasseri (SweetPhoto Nerf trijumeau et ganglion de Gasser La Névralgie du TrijumeauGanglion Trigéminal ; Ganglion de Gasser


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リンク元三叉神経節
関連記事ganglion

三叉神経節」

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trigeminal ganglion (KH)
ganglion trigeminale
ガッセル神経節 Gasser ganglion ganglion Gasseri半月神経節 semilunar ganglion (KH) ganglion semilunare
眼神経上顎神経下顎神経



Henry Gray (1825-1861). Anatomy of the Human Body. 1918.

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ganglion」

  [★] ガングリオン

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「an encapsulated neural structure consisting of a collection of cell bodies or neurons」

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「神経節・ガングリオン,結節腫 《主に手首にできる良性の嚢腫(のうしゆ)》・〔知的・産業的活動の〕中心,中枢 〔of〕」




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