WordNet

act so as to bring into existence; "effect a change"
a symptom caused by an illness or a drug; "the effects of sleep loss"; "the effect of the anesthetic"
(of a law) having legal validity; "the law is still in effect" (同)force
the central meaning or theme of a speech or literary work (同)essence, burden, core, gist
an impression (especially one that is artificial or contrived); "he just did it for effect"
produce; "The scientists set up a shock wave" (同)effectuate, set_up
property of a personal character that is portable but not used in business; "she left some of her personal effects in the house"; "I watched over their effects until they returned" (同)personal_effects
the 7th letter of the Roman alphabet (同)g

PrepTutorEJDIC

〈C〉〈U〉『結果』 / 〈C〉〈U〉(…への)『効果』,効きめ,影響《+『on』(『upon』)+『名』》 / 〈C〉(色・音・形などの)印象,感銘 / 《複数形で》品物;身の回り品;動産,財産 / (結果として)…‘を'『もたらす』;〈目的など〉‘を'果たす,遂行する

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1. 造血細胞移植後の移植片対腫瘍効果の生物学 biology of the graft versus tumor effect following hematopoietic cell transplantation
2. 成人における急性リンパ芽球性白血病に対する造血細胞移植の一般原則 general principles of hematopoietic cell transplantation for acute lymphoblastic leukemia in adults
3. 急性移植片対宿主病の予防 prevention of acute graft versus host disease
4. 慢性リンパ性白血病における造血細胞移植 hematopoietic cell transplantation in chronic lymphocytic leukemia
5. 成人におけるフィラデルフィア染色体陰性急性リンパ芽球性白血病に対する寛解後療法 post remission therapy for philadelphia chromosome negative acute lymphoblastic leukemia in adults

Is there a stronger graft-versus-leukemia effect using HLA-haploidentical donors than with HLA-identical siblings?

Ringdén O1, Labopin M2, Ciceri F3, Velardi A4, Bacigalupo A5, Arcese W6, Ghavamzadeh A7, Hamladji RM8, Schmid C9, Nagler A2,10, Mohty M2.
Leukemia.Leukemia.2015 Aug 21. doi: 10.1038/leu.2015.232. [Epub ahead of print]
Haploidentical hematopoietic stem cell transplants are increasingly used, but it is unknown whether they have a stronger graft-versus-leukemia (GVL) effect. We analyzed 10 679 acute leukemia patients who underwent HSCT from an HLA-matched sibling donor (MSD, n=9815) or a haploidentical donor (⩾
PMID 26293645

Valproic Acid Ameliorates Graft-versus-Host Disease by Downregulating Th1 and Th17 Cells.

Long J1, Chang L1, Shen Y2, Gao WH1, Wu YN1, Dou HB1, Huang MM1, Wang Y1, Fang WY1, Shan JH1, Wang YY3, Zhu J3, Chen Z3, Hu J4.
Journal of immunology (Baltimore, Md. : 1950).J Immunol.2015 Aug 15;195(4):1849-57. doi: 10.4049/jimmunol.1500578. Epub 2015 Jul 15.
Graft-versus-host disease (GVHD) is the major complication after allogeneic bone marrow transplantation. Valproic acid (VPA) was described as a histone deacetylase inhibitor that had anti-inflammatory effects and reduced the production of proinflammatory cytokines in experimental autoimmune disease
PMID 26179902

Umbilical cord blood-derived mesenchymal stem cells ameliorate graft-versus-host disease following allogeneic hematopoietic stem cell transplantation through multiple immunoregulations.

Wu QL1, Liu XY, Nie DM, Zhu XX, Fang J, You Y, Zhong ZD, Xia LH, Hong M.
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban.J Huazhong Univ Sci Technolog Med Sci.2015 Aug;35(4):477-84. doi: 10.1007/s11596-015-1456-8. Epub 2015 Jul 31.
Although mesenchymal stem cells (MSCs) are increasingly used to treat graft-versus-host disease (GVHD), their immune regulatory mechanism in the process is elusive. The present study aimed to investigate the curative effect of third-party umbilical cord blood-derived human MSCs (UCB-hMSCs) on GVHD p
PMID 26223913