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1. 腱滑膜巨細胞腫といった軟部組織や骨に影響を与えるさまざまな良性疾患への抗腫瘍療法antineoplastic therapy for miscellaneous benign diseases affecting soft tissue and bone including tenosynovial giant cell tumor [show details]
… villonodular synovitis (tenosynovial giant cell tumor), and symptomatic vertebral hemangiomas. Radiation therapy for other conditions affecting soft tissue, such as desmoid tumors, keloid, ganglia, and Dupuytren …
2. 造血細胞移植後の移植片対腫瘍効果の生物学biology of the graft versus tumor effect following hematopoietic cell transplantation [show details]
… transfect tumor cells with costimulatory genes. In animal models, injection of transfected tumor cells resulted in an effective immune response against both the transfected and wild type tumor cells . The …
3. 非膵島細胞腫瘍性低血糖nonislet cell tumor hypoglycemia [show details]
… Hypoglycemia can be caused by several tumors, including islet and nonislet tumors. Nonislet cell tumor hypoglycemia (NICTH) is a rare but serious complication of malignancy . The most common cause of …
4. 精巣胚細胞腫瘍における血清腫瘍マーカーserum tumor markers in testicular germ cell tumors [show details]
…commonly elevated tumor marker in testicular cancer. The normal value in men is less than 5 to 10 international units/L. The production of hCG by testicular nonseminomatous germ cell tumors (NSGCTs) varies …
5. 頭頸部の扁平上皮癌化：分子学的および遺伝学的変化head and neck squamous cell carcinogenesis molecular and genetic alterations [show details]
… overexpression of co-inhibitory receptors/ligands on the tumor cell surface/lymphocytes, such as programmed cell death protein 1 (PD-1) and programmed cell death ligand 1 (PD-L1), referred to as immune checkpoints …

English Journal

Three-dimensional cultured tissue constructs that imitate human living tissue organization for analysis of tumor cell invasion.

Iwai S, Kishimoto S, Amano Y, Nishiguchi A, Matsusaki M, Takeshita A, Akashi M.
Journal of biomedical materials research. Part A. 2019 Feb;107(2)292-300.
Preventing cancer metastasis requires a thorough understanding of cancer cell invasion. These phenomena occur in human 3-D living tissues. To this end, we developed a human cell-based three-dimensional (3-D) cultured tissue constructs that imitate in vivo human tissue organization. We investigated w
PMID 29280265

The tumor suppressor p53 can promote collective cellular migration.

He S, Carman CV, Lee JH, Lan B, Koehler S, Atia L, Park CY, Kim JH, Mitchel JA, Park JA, Butler JP, Lu Q, Fredberg JJ.
PloS one. 2019 ;14(2)e0202065.
Loss of function of the tumor suppressor p53 is known to increase the rate of migration of cells transiting the narrow pores of the traditional Boyden chamber assay. Here by contrast we investigate how p53 impacts the rate of cellular migration within a 2D confluent cell layer and a 3D collagen-embe
PMID 30707705

Antioxidant, antimicrobial and cytotoxic potential of silver nanoparticles synthesized using flavonoid rich alcoholic leaves extract of Reinwardtia indica.

Upadhyay P, Mishra SK, Purohit S, Dubey GP, Singh Chauhan B, Srikrishna S.
Drug and chemical toxicology. 2019 Jan;42(1)65-75.
The present work discusses the establishment of a green route for the rapid synthesis of silver nanoparticles (AgNPs) using an alcoholic extract of Reinwardtia indica (AERI) leaves which act as a reducing as well as a capping agent. The change in color from yellowish green to dark brown confirmed th
PMID 30033778

Japanese Journal

症例報告巨大卵巣腫瘍術後に虫垂杯細胞カルチノイドの両側卵巣転移と判明した1例

藤上友輔,伴建二,赤木佳奈,矢口愛弓,寺田亜希子,松本久宣,岡垣篤彦,巽啓司
産婦人科の進歩 71(2), 149-154, 2019-05
NAID 40021898023

P40 expression in small cell lung cancer: The presence of p40-positive cells does not always indicate squamous differentiation

Nakajima Naoki,Yoshizawa Akihiko,Moriyoshi Koki,Sonobe Makoto,Menju Toshi,Sumiyoshi Shinji,Date Hiroshi,Haga Hironori
Thoracic Cancer 10(5), 1188-1192, 2019-05
… Background: Small cell lung cancer (SCLC) is normally diagnosed with hematoxylin and eosin stains, although some cases require immunohistochemistry (IHC). … P40 is highly sensitive and specific for squamous cell carcinoma and is thus considered the best marker for this cancer. … 1% of tumor cells. … In the remaining five cases, 1–5% of tumor cells expressed p40, and in three of these, the cells expressing p40 also expressed TTF‐1 and neuroendocrine markers. …
NAID 120006624101

Synergistic interaction of gemcitabine and paclitaxel by modulating acetylation and polymerization of tubulin in non-small cell lung cancer cell lines

Effendi Wiwin Is,Nagano Tatsuya,Tachihara Motoko,Umezawa Kanoko,Kiriu Tatsunori,Dokuni Ryota,Katsurada Masahiro,Yamamoto Masatsugu,Kobayashi Kazuyuki,Nishimura Yoshihiro
Cancer Management and Research (11), 3669-3679, 2019-04-29
… Purpose: The aim of this study was to elucidate a potential effect of this combination on the proliferation of two non-small cell lung cancer (NSCLC) cell lines, A549 and H520. … Materials and methods: Cell lines were treated with GEM and PTX for 48 hours to evaluate the half maximal inhibitory concentration (IC50). … To determine the combination index (CI), cell lines were exposed to GEM and PTX, in a constant ratio of IC50, by various combination treatments. …
NAID 120006631017