WordNet

people descended from a common ancestor; "his family has lived in Massachusetts since the Mayflower" (同)family line, folk, kinfolk, kinsfolk, sept, phratry
primary social group; parents and children; "he wanted to have a good job before starting a family" (同)family unit
an association of people who share common beliefs or activities; "the message was addressed not just to employees but to every member of the company family"; "the church welcomed new members into its fellowship" (同)fellowship
a social unit living together; "he moved his family to Virginia"; "It was a good Christian household"; "I waited until the whole house was asleep"; "the teacher asked how many people made up his home" (同)household, house, home, menage
(biology) a taxonomic group containing one or more genera; "sharks belong to the fish family"
the 4th letter of the Roman alphabet (同)d

PrepTutorEJDIC

《集合的に》『家族』,家庭 / 〈U〉《時にa family》(一家の)子供たち / 〈C〉(血縁に関係ある)『親族』,身内,一族,一門 / 〈U〉『家柄』;(特に)名門 / 〈C〉(関係ある人・物の)一団,一群,(生物分類の)科《+『of』+『名』》
deuteriumの化学記号
deoxyribonucleic acidディオキシリボ核酸

UpToDate Contents

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1. 色素性乾皮症xeroderma pigmentosum [show details]
…the clinical presentation, a family history consistent with autosomal recessive inheritance, and/or confirmatory genetic testing . Molecular testing approaches for the diagnosis of XP include serial …
2. 原発性免疫不全症における悪性腫瘍malignancy in primary immunodeficiency [show details]
…Therefore, patients with genetically defined congenital immunodeficiency in low-affinity immunoglobulin Fc-gamma-receptor IIIA (FCGR3A) and minichromosome maintenance complex component 4 (MCM4) genes mutation are …
3. 脂肪異栄養症症候群lipodystrophic syndromes [show details]
…has been linked to homozygous mutations in RECQL2, which encodes a DNA helicase . In contrast, the molecular genetic basis and inheritance patterns have yet to be clarified for the following syndromes: Cockayne …
4. 皮膚石灰沈着症：病院および患者の評価calcinosis cutis etiology and patient evaluation [show details]
… Werner syndrome – Werner syndrome is an autosomal recessively inherited mutation in the WRN gene, which encodes the RecQ-type DNA helicase. This mutation leads to premature aging and scleroderma-like skin …
5. 家族性急性白血病および骨髄異形成症候群familial acute leukemia and myelodysplastic syndromes [show details]
… for diagnosing a familial AL/MDS syndrome is informed by the testing strategy, as described below. Cultured skin fibroblasts are generally the preferred source for germline genetic testing. However …

English Journal

DDX43 prefers single strand substrate and its full binding activity requires physical connection of all domains.

Wu H, Zhai LT, Chen PY, Xi XG.
Biochemical and biophysical research communications. 2019 Dec;520(3)594-599.
DDX43 is a cancer/testis antigen and is thought to stimulate oncogenic pathways in cell proliferation, while its specific function in cancer development is largely unexplored. DDX43 is the member of RNA helicase in DEAD-box family, consists of conserved helicase core and a single K-homology (KH) dom
PMID 31623828

Branched unwinding mechanism of the Pif1 family of DNA helicases.

Singh SP, Soranno A, Sparks MA, Galletto R.
Proceedings of the National Academy of Sciences of the United States of America. 2019 Nov;().
Members of the Pif1 family of helicases function in multiple pathways that involve DNA synthesis: DNA replication across G-quadruplexes; break-induced replication; and processing of long flaps during Okazaki fragment maturation. Furthermore, Pif1 increases strand-displacement DNA synthesis by DNA po
PMID 31744872

Coevolutionary Couplings Unravel PAM-Proximal Constraints of CRISPR-SpCas9.

Li Y, De la Paz JA, Jiang X, Liu R, Pokkulandra AP, Bleris L, Morcos F.
Biophysical journal. 2019 Nov;117(9)1684-1691.
The clustered regularly interspaced short palindromic repeats (CRISPR) system, an immune system analog found in prokaryotes, allows a single-guide RNA to direct a CRISPR-associated protein (Cas) with combined helicase and nuclease activity to DNA. The presence of a specific protospacer adjacent moti
PMID 31648792

Japanese Journal

核内受容体constitutive androstane receptor（CAR）の構造と機能

井上義雄
薬学雑誌. 乙号 136(2), 297-308, 2016
… A member of the DEAD box DNA/RNA helicase family (DP97) and protein arginine methyltransferase 5 (PRMT5) were found to be gene (or promotor)-specific coactivators of CAR. …
NAID 130005121467

Structural mechanisms of human RecQ helicases WRN and BLM

Kitano Ken
2014-10-29
… The RecQ family DNA helicases WRN (Werner syndrome protein) and BLM (Bloom syndrome protein) play a key role in protecting the genome against deleterious changes. … WRN and BLM are distinguished from other helicases by possessing signature tandem domains toward the C terminus, referred to as the RecQ C-terminal (RQC) and helicase-and-ribonuclease D-C-terminal (HRDC) domains. …
NAID 120005841619

RecQ5 Protein Translocation into the Nucleus by a Nuclear Localization Signal

Sakurai Haruna,Tsutsui Ayaka,Higashi Takahiro [他],Azuma Rika,Ito Fumiaki,Kawasaki Katsumi
Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 36(7), 1159-1166, 2013
… RecQ5, a member of the RecQ helicase family, maintains genome stability <i>via</i> … participation in many DNA metabolic processes including DNA repair, DNA resolution, and RNA transcription, processes occurring in the nucleus. … Previously, we reported that RecQ5 and Rad51, also involved in DNA repair, become co-localized in nuclei when co-expressed in cultured cells. …
NAID 130003361476