DNAヘリカーゼ
WordNet
- the 4th letter of the Roman alphabet (同)d
PrepTutorEJDIC
- deuteriumの化学記号
- deoxyribonucleic acidディオキシリボ核酸
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/08/01 13:46:39」(JST)
[Wiki en表示]
| DNA helicase |
| Identifiers |
| EC number |
3.6.4.12 |
| Databases |
| IntEnz |
IntEnz view |
| BRENDA |
BRENDA entry |
| ExPASy |
NiceZyme view |
| KEGG |
KEGG entry |
| MetaCyc |
metabolic pathway |
| PRIAM |
profile |
| PDB structures |
RCSB PDB PDBe PDBsum |
| Search |
| PMC |
articles |
| PubMed |
articles |
| NCBI |
proteins |
|
DNA helicase (EC 3.6.4.12, 3' to 5' DNA helicase, 3'-5' DNA helicase, 3'-5' PfDH, 5' to 3' DNA helicase, AvDH1, BACH1 helicase, BcMCM, BLM protein, BRCA1-associated C-terminal helicase, CeWRN-1, Dbp9p, DmRECQ5, DNA helicase 120, DNA helicase A, DNA helicase E, DNA helicase II, DNA helicase III, DNA helicase RECQL5beta, DNA helicase VI, dnaB, DnaB helicase E1, helicase HDH IV, Hel E, helicase DnaB, helicase domain of bacteriophage T7 gene 4 protein helicase, PcrA helicase, UvrD, hHcsA, Hmi1p, hPif1, MCM helicase, MCM protein, MER3 helicase, MER3 protein, MPH1, PcrA, PDH120, PfDH A, Pfh1p, PIF1) is an enzyme with system name ATP phosphohydrolase (DNA helix unwinding).[1][2][3][4][5][6][7][8][9][10][11][12][13][14][15] This enzyme catalyses the following chemical reaction
- ATP + H2O ADP + phosphate
DNA helicases utilize the energy from ATP hydrolysis to unwind double-stranded DNA.
References[edit]
- ^ Ozsoy, A.Z., Sekelsky, J.J. and Matson, S.W. (2001). "Biochemical characterization of the small isoform of Drosophila melanogaster RECQ5 helicase". Nucleic Acids Res. 29: 2986–2993. PMID 11452023.
- ^ Tanner, J.A., Watt, R.M., Chai, Y.B., Lu, L.Y., Lin, M.C., Peiris, J.S., Poon, L.L., Kung, H.F. and Huang, J.D. (2003). "The severe acute respiratory syndrome (SARS) coronavirus NTPase/helicase belongs to a distinct class of 5′ to 3′ viral helicases". J. Biol. Chem. 278: 39578–39582. PMID 12917423.
- ^ Nakagawa, T., Flores-Rozas, H. and Kolodner, R.D. (2001). "The MER3 helicase involved in meiotic crossing over is stimulated by single-stranded DNA-binding proteins and unwinds DNA in the 3′ to 5′ direction". J. Biol. Chem. 276: 31487–31493. PMID 11376001.
- ^ Lee, C. and Seo, Y.S. (1998). "Isolation and characterization of a processive DNA helicase from the fission yeast Schizosaccharomyces pombe that translocates in a 5′-to-3′ direction". Biochem. J. 334: 377–386. PMID 9716495.
- ^ Phan, T.N., Ehtesham, N.Z., Tuteja, R. and Tuteja, N. (2003). "A novel nuclear DNA helicase with high specific activity from Pisum sativum catalytically translocates in the 3′→5′ direction". Eur. J. Biochem. 270: 1735–1745. PMID 12694186.
- ^ Bernstein, D.A., Zittel, M.C. and Keck, J.L. (2003). "High-resolution structure of the E. coli RecQ helicase catalytic core". EMBO J. 22: 4910–4921. PMID 14517231.
- ^ Pike, A.C., Shrestha, B., Popuri, V., Burgess-Brown, N., Muzzolini, L., Costantini, S., Vindigni, A. and Gileadi, O. (2009). "Structure of the human RECQ1 helicase reveals a putative strand-separation pin". Proc. Natl. Acad. Sci. USA 106: 1039–1044. PMID 19151156.
- ^ Curti, E., Smerdon, S.J. and Davis, E.O. (2007). "Characterization of the helicase activity and substrate specificity of Mycobacterium tuberculosis UvrD". J. Bacteriol. 189: 1542–1555. PMID 17158674.
- ^ Frick, D.N. (2007). "The hepatitis C virus NS3 protein: a model RNA helicase and potential drug target". Curr. Issues Mol. Biol. 9: 1–20. PMID 17263143.
- ^ Ivanov, K.A. and Ziebuhr, J. (2004). "Human coronavirus 229E nonstructural protein 13: characterization of duplex-unwinding, nucleoside triphosphatase, and RNA 5′-triphosphatase activities". J. Virol. 78: 7833–7838. PMID 15220459.
- ^ Ivessa, A.S., Zhou, J.Q., Schulz, V.P., Monson, E.K. and Zakian, V.A. (2002). "Saccharomyces Rrm3p, a 5′ to 3′ DNA helicase that promotes replication fork progression through telomeric and subtelomeric DNA". Genes Dev. 16: 1383–1396. PMID 12050116.
- ^ Zhou, J.Q., Qi, H., Schulz, V.P., Mateyak, M.K., Monson, E.K. and Zakian, V.A. (2002). "Schizosaccharomyces pombe pfh1+ encodes an essential 5′ to 3′ DNA helicase that is a member of the PIF1 subfamily of DNA helicases". Mol. Biol. Cell 13: 2180–2191. PMID 12058079.
- ^ George, T., Wen, Q., Griffiths, R., Ganesh, A., Meuth, M. and Sanders, C.M. (2009). "Human Pif1 helicase unwinds synthetic DNA structures resembling stalled DNA replication forks". Nucleic Acids Res. 37: 6491–6502. PMID 19700773.
- ^ Naqvi, A., Tinsley, E. and Khan, S.A. (2003). "Purification and characterization of the PcrA helicase of Bacillus anthracis". J. Bacteriol. 185: 6633–6639. PMID 14594837.
- ^ Ruiz-Maso, J.A., Anand, S.P., Espinosa, M., Khan, S.A. and del Solar, G. (2006). "Genetic and biochemical characterization of the Streptococcus pneumoniae PcrA helicase and its role in plasmid rolling circle replication". J. Bacteriol. 188: 7416–7425. PMID 16936036.
See also[edit]
External links[edit]
- DNA helicase at the US National Library of Medicine Medical Subject Headings (MeSH)
UpToDate Contents
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English Journal
- Identification of key transcription factors in caerulein‑induced pancreatitis through expression profiling data.
- Qi D1, Wu B2, Tong D2, Pan Y2, Chen W2.
- Molecular medicine reports.Mol Med Rep.2015 Aug;12(2):2570-6. doi: 10.3892/mmr.2015.3773. Epub 2015 May 12.
- The current study aimed to isolate key transcription factors (TFs) in caerulein‑induced pancreatitis, and to identify the difference between wild type and Mist1 knockout (KO) mice, in order to elucidate the contribution of Mist1 to pancreatitis. The gene profile of GSE3644 was downloaded from th
- PMID 25975747
- Identification and rapid diagnosis of the pathogen responsible for haemorrhagic disease of the gill of Allogynogenetic crucian carp.
- Zhu M1, Liu B1, Cao G1, Hu X1, Wei Y1, Yi J2, Zhou Y3, Pan G1, Wang J1, Xue R4, Gong C5.
- Journal of virological methods.J Virol Methods.2015 Jul;219:67-74. doi: 10.1016/j.jviromet.2015.03.019. Epub 2015 Mar 31.
- In recent years, an epizootic causing severe mortality among Allogynogenetic crucian carp (ACC), designated as haemorrhagic disease of ACC gill, occurred in Yancheng city of Jiangsu province of China. Obvious haemorrhage in the gills of moribund fish and a mortality rate of 100% were observed when A
- PMID 25839411
- Apogossypolone induces reactive oxygen species accumulation and controls cell cycle progression in Raji Burkkit's lymphoma cells.
- Hu ZY1, Xu F1, Sun R1, Chen YF1, Zhang DS1, Fan YH2, Sun J1.
- Molecular medicine reports.Mol Med Rep.2015 Jul;12(1):337-44. doi: 10.3892/mmr.2015.3404. Epub 2015 Mar 3.
- Burkitt's lymphoma (BL) is a highly aggressive type of non-Hodgkin's lymphoma, with marked rates of proliferation and metabolism. The expression levels of the translocated cellular Myc (c-Myc) oncogene and Epstein-Barr virus infection have an oncogenic role in facilitating tumor progression and main
- PMID 25738577
Japanese Journal
- G364R mutation of MCM4 detected in human skin cancer cells affects DNA helicase activity of MCM4/6/7 complex
- 植物のTWINKLE は葉緑体DNA 複製に関わるDNA プライマーゼか? : 細胞内局在の検討
Related Links
- http://www.garlandscience.com/product... DNA helicase separates nucleic acid duplexes into their component strands. This video describes the actions of DNA helicase. This video is from: Essential Cell ...
- Part II Inchworm mechanism Most helicase require a ssDNA (tail) that is adjacent to a dsDNA region in order to initiate unwinding of the duplex. Hence, the ssDNA serve as a loading strand and a starting point to unwind duplex DNA.
★リンクテーブル★
[★]
- 英
- DNA helicase
- 同
- dnaB DnaB
- DNA巻戻し蛋白質 DNA unwinding protein、DNA巻戻し酵素 DNA unwinding enzyme
- 二本鎖DNAを部分的に一本鎖DNAに巻き戻す酵素。
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DNAヘリカーゼファミリー
[★]
[★]
- 英
- deoxyribonucleic acid
- 同
- デオキシリボ核酸
- 関
- リボ核酸 RNA
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ヘリカーゼ、ヘリケース