WordNet
- relying on or requiring a person or thing for support, supply, or what is needed; "dependent children"; "dependent on moisture"
- addicted to a drug (同)dependant, drug-addicted, hooked, strung-out
- contingent on something else (同)dependant, qualified
- (of a clause) unable to stand alone syntactically as a complete sentence; "a subordinate (or dependent) clause functions as a noun or adjective or adverb within a sentence" (同)subordinate
- the 9th letter of the Roman alphabet (同)i
- the 4th letter of the Roman alphabet (同)d
- the 18th letter of the Roman alphabet (同)r
PrepTutorEJDIC
- 『頼っている』,依存している,従属している / 扶養される人(家族)
- 『私は』私が
- iodineの化学記号
- deuteriumの化学記号
- resistance / 17歳以下父兄同伴映画の表示 / rook
- deoxyribonucleic acidディオキシリボ核酸
UpToDate Contents
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- 1. 遺伝性疾患の基本原則 basic principles of genetic disease
- 2. 分子遺伝学の原理 principles of molecular genetics
- 3. 抗核抗体の測定および臨床的意義 measurement and clinical significance of antinuclear antibodies
- 4. 急性骨髄性白血病の分子遺伝学 molecular genetics of acute myeloid leukemia
- 5. ハンタウイルス感染の疫学および診断 epidemiology and diagnosis of hantavirus infections
English Journal
- Fructose bisphosphate aldolase is involved in the control of RNA polymerase III-directed transcription.
- Cieśla M1, Mierzejewska J2, Adamczyk M2, Farrants AK3, Boguta M4.Author information 1Institute of Biochemistry and Biophysics, Polish Academy of Sciences, ul. Pawinskiego 5a, 02-106 Warsaw, Poland.2Institute of Biotechnology, Faculty of Chemistry, Warsaw University of Technology, ul. Noakowskiego 3, 00-664 Warsaw, Poland.3Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, SE 106 91 Stockholm, Sweden.4Institute of Biochemistry and Biophysics, Polish Academy of Sciences, ul. Pawinskiego 5a, 02-106 Warsaw, Poland; Institute of Biotechnology, Faculty of Chemistry, Warsaw University of Technology, ul. Noakowskiego 3, 00-664 Warsaw, Poland. Electronic address: magda@ibb.waw.pl.AbstractYeast Fba1 (fructose 1,6-bisphosphate aldolase) is a glycolytic enzyme essential for viability. The overproduction of Fba1 enables overcoming of a severe growth defect caused by a missense mutation rpc128-1007 in a gene encoding the C128 protein, the second largest subunit of the RNA polymerase III complex. The suppression of the growth phenotype by Fba1 is accompanied by enhanced de novo tRNA transcription in rpc128-1007 cells. We inactivated residues critical for the catalytic activity of Fba1. Overproduction of inactive aldolase still suppressed the rpc128-1007 phenotype, indicating that the function of this glycolytic enzyme in RNA polymerase III transcription is independent of its catalytic activity. Yeast Fba1 was determined to interact with the RNA polymerase III complex by coimmunoprecipitation. Additionally, a role of aldolase in control of tRNA transcription was confirmed by ChIP experiments. The results indicate a novel direct relationship between RNA polymerase III transcription and aldolase.
- Biochimica et biophysica acta.Biochim Biophys Acta.2014 Jun;1843(6):1103-10. doi: 10.1016/j.bbamcr.2014.02.007. Epub 2014 Feb 24.
- Yeast Fba1 (fructose 1,6-bisphosphate aldolase) is a glycolytic enzyme essential for viability. The overproduction of Fba1 enables overcoming of a severe growth defect caused by a missense mutation rpc128-1007 in a gene encoding the C128 protein, the second largest subunit of the RNA polymerase III
- PMID 24576411
- Conformation and recognition of DNA damaged by antitumor cis-dichlorido platinum(II) complex of CDK inhibitor bohemine.
- Novakova O1, Liskova B1, Vystrcilova J1, Suchankova T1, Vrana O1, Starha P2, Travnicek Z2, Brabec V3.Author information 1Institute of Biophysics, Academy of Sciences of The Czech Republic, v.v.i., CZ-61265 Brno, Czech Republic.2Regional Centre of Advanced Technologies and Materials, Department of Inorganic Chemistry, Faculty of Science, Palacky University, 17. listopadu 12, CZ-77146 Olomouc, Czech Republic.3Institute of Biophysics, Academy of Sciences of The Czech Republic, v.v.i., CZ-61265 Brno, Czech Republic. Electronic address: brabec@ibp.cz.AbstractA substitution of the ammine ligands of cisplatin, cis-[Pt(NH3)2Cl2], for cyclin dependent kinase (CDK) inhibitor bohemine (boh), [2-(3-hydroxypropylamino)-6-benzylamino-9-isopropylpurine], results in a compound, cis-[Pt(boh)2Cl2] (C1), with the unique anticancer profile which may be associated with some features of the damaged DNA and/or its cellular processing (Travnicek Z et al. (2003) J Inorg Biochem94, 307-316; Liskova B (2012) Chem Res Toxicol25, 500-509). A combination of biochemical and molecular biology techniques was used to establish mechanistic differences between cisplatin and C1 with respect to the DNA damage they produce and their interactions with critical DNA-binding proteins, DNA-processing enzymes and glutathione. The results show that replacement of the NH3 groups in cisplatin by bohemine modulates some aspects of the mechanism of action of C1. More specifically, the results of the present work are consistent with the thesis that, in comparison with cisplatin, effects of other factors, such as: (i) slower rate of initial binding of C1 to DNA; (ii) the lower efficiency of C1 to form bifunctional adducts; (iii) the reduced bend of longitudinal DNA axis induced by the major 1,2-GG intrastrand cross-link of C1; (iv) the reduced affinity of HMG domain proteins to the major adduct of C1; (v) the enhanced efficiency of the DNA adducts of C1 to block DNA polymerization and to inhibit transcription activity of human RNA pol II and RNA transcription; (vi) slower rate of the reaction of C1 with glutathione, may partially contribute to the unique activity of C1.
- European journal of medicinal chemistry.Eur J Med Chem.2014 May 6;78:54-64. doi: 10.1016/j.ejmech.2014.03.041. Epub 2014 Mar 15.
- A substitution of the ammine ligands of cisplatin, cis-[Pt(NH3)2Cl2], for cyclin dependent kinase (CDK) inhibitor bohemine (boh), [2-(3-hydroxypropylamino)-6-benzylamino-9-isopropylpurine], results in a compound, cis-[Pt(boh)2Cl2] (C1), with the unique anticancer profile which may be associated with
- PMID 24675180
- Response to: 'Are autoantibodies to RNA-polymerase III to be incorporated in routine diagnostic laboratory algorithms for systemic autoimmune rheumatic diseases?' by Jan Damoiseaux.
- Fransen J1, Pope J, Baron M, Johnson S, Khanna D, Matucci-Cerinic M, Tyndall A, van den Hoogen F.Author information 1Department of Rheumatology, Radboud University Medical Center, , Nijmegen, The Netherlands.KEYWORDS: Rheumatoid Arthritis, Systemic Sclerosis, Treatment
- Annals of the rheumatic diseases.Ann Rheum Dis.2014 May 1;73(5):e30. doi: 10.1136/annrheumdis-2014-205200. Epub 2014 Feb 3.
- PMID 24492752
Japanese Journal
- Casein Kinase II (CK-II)-Mediated Stimulation of HIV-1 Reverse Transcriptase Activity and Characterization of Selective Inhibitors in Vitro
- HARADA Shigeyoshi,HANEDA Eiji,MAEKAWA Toshiro,MORIKAWA Yuko,FUNAYAMA Shinji,NAGATA Nobuyuki,OHTSUKI Kenzo
- Biological & pharmaceutical bulletin 22(10), 1122-1126, 1999-10-15
- … The physiological significance of the casein kinase II (CK-II)-mediated phosphorylation of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) on its three enzymatic activities [RNA-dependent DNA polymerase (RDDP), DNA-dependent DNA polymerase (DDDP) and ribonuclease H (RNase H)] was investigated in vitro. …
- NAID 110003639556
- Synchronous Alterations of RNA Synthesis and DNA-dependent RNA Polymerase Activities during Development of Dictyostelium discoideum
- Yagura Tatsuo,Yagura Miyuki,Takiya Shigeharu,Iwabuchi Masaki
- Plant and cell physiology 23(2), 237-247, 1982-03
- … The relation of RNA synthesis and RNA polymerase activities during the development of Dictyostelium discoideum was investigated. …
- NAID 110003718171
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★リンクテーブル★
| リンク元 | 「DNA依存性RNAポリメラーゼIII」 |
| 関連記事 | 「D」「II」「R」「I」「dependent」 |
「DNA依存性RNAポリメラーゼIII」
「D」
- アスパラギン酸
- ジヒドロウリジン
- 遠位の distal,
- うつ病 depression
- 下行結腸 descending colon(大腸内視鏡検査の結果を記載するときに用いる)
「II」
「R」
「I」
「dependent」
- adj.
- 依存性の、依存的な、依存型の、依存の