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cyclooxygenase 1

cyclooxygenase 1

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2012/07/15 13:32:01」(JST)

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  • Liquid chromatography-tandem mass spectrometry for simultaneous measurement of thromboxane B2 and 12(S)-hydroxyeicosatetraenoic acid in serum.
  • Squellerio I1, Porro B2, Songia P3, Veglia F4, Caruso D5, Tremoli E6, Cavalca V7.
  • Journal of pharmaceutical and biomedical analysis.J Pharm Biomed Anal.2014 Aug 5;96:256-62. doi: 10.1016/j.jpba.2014.04.004. Epub 2014 Apr 13.
  • Arachidonic acid (AA) is metabolized in human platelets by two main pathways: via cyclooxygenase (COX-1) to prostaglandins and thromboxane (TX)A2 and via 12-lipoxygenase (12-LOX) to 12(S)-hydroxyeicosatetraenoic acid (12(S)-HETE). While COX products are known to regulate platelet reactivity, the rol
  • PMID 24786190
  • Aspirin may modify tumor microenvironment via antiplatelet effect.
  • Su BB1, Chen JH2, Shi H1, Chen QQ1, Wan J3.
  • Medical hypotheses.Med Hypotheses.2014 Aug;83(2):148-50. doi: 10.1016/j.mehy.2014.05.007. Epub 2014 May 20.
  • High-quality evidence suggests that aspirin is a promising agent for cancer prevention and treatment. Direct inhibition of cyclooxygenase-2 (COX-2) pathway is generally thought to be the main mechanism by which aspirin inhibits cancer development. However, either pharmacological properties of aspiri
  • PMID 24908358
  • Protective effect of nimesulide against hepatic ischemia/reperfusion injury in rats: Effects on oxidant/antioxidants, DNA mutation and COX-1/COX-2 levels.
  • Demiryilmaz I1, Turan MI2, Kisaoglu A3, Gulapoglu M4, Yilmaz I5, Suleyman H6.
  • Pharmacological reports : PR.Pharmacol Rep.2014 Aug;66(4):647-52. doi: 10.1016/j.pharep.2014.02.015. Epub 2014 Mar 11.
  • BACKGROUND: Nimesulide is a pharmacological agent and selective COX-2 inhibitor. It has anti-inflammatory, analgesic and antipyretic properties. The purpose of this study was to investigate the effect of nimesulide on oxidant/antioxidant, DNA mutation and COX-1/COX-2 activities in rat liver tissue w
  • PMID 24948067


  • The comprehensive assessment of local immune status of ovarian cancer by the clustering of multiple immune factors.
  • Hamanishi Junzo,Mandai Masaki,Abiko Kaoru,Matsumura Noriomi,Baba Tsukasa,Yoshioka Yumiko,Kosaka Kenzo,Konishi Ikuo
  • Clinical immunology 141(3), 338-347, 2011-12
  • … The numbers of CD1α+, CD4+, CD8+, CD57+, forkhead box P3+ and programmed cell death-1+ cells were counted, and the intensity of immunosuppressive factors, such as programmed cell death-1 ligand (PD-L)1, PD-L2, cyclooxygenase (COX)-1, COX-2 and transforming growth factor β1, were evaluated in 70 ovarian cancer specimens stained by immunohistochemistry. …
  • NAID 120003610113
  • An intact mitochondrial cox1 gene and a pseudogene with different genomic configurations are present in apple cultivars 'Golden Delicious' and 'Delicious': Evolutionary aspects
  • Wakatsuki Akihito,Kitazaki Kazuyoshi,Kato Sumie,Kishima Yuji,Mikami Tetsuo
  • Scientia Horticulturae 130(1), 49-53, 2011-08-26
  • … We have characterized the mitochondrial cox1 gene copies in two apple cultivars 'Golden Delicious' and 'Delicious'. … Both the cultivars contained an intact copy and a truncated copy of cox1. … The intact 'Golden Delicious' and 'Delicious' cox1 genes, designated G-cox1 and D-cox1, respectively, were both found to be actually transcribed to give an RNA of approximately 1.7 kb. …
  • NAID 120003898267


COX(シクロオキシゲナーゼ)はアラキドン酸カスケードの最初に働く律速酵素 COX-1(構成型) 胃、血小板、腎臓その他のほとんどの組織で常時発現している構成型の酵素。COX-1が産生するプロスタグランジンは胃粘液分泌増加、血流 ...
表1 COX-1とCOX-2の比較(参考文献の大野氏の表5を改変し引用) 特性 COX-1 COX-2 mRNAのサイズ 3kb 4kb 遺伝子の局在 9番染色体上 1番染色体上 酵素の性質 構成酵素 誘導酵素(脳・腎では構成 ...






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「the 3rd letter of the Roman alphabet」

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「(music) the keynote of the scale of C major」

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「a general-purpose programing language closely associated with the UNIX operating system」

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「act as the coxswain, in a boat race」

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  [★] シクロオキシゲナーゼ COX

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