CD40

出典: meddic

発現細胞

  • B細胞
  • マクロファージ
  • 樹状細胞
  • basal epithelial cells

機能

B細胞

  • receptor for costimulatory signal for B cells (IMM.785)
  • B細胞の増殖、分化、isotype switching of B cells (IMM.785)


Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2012/05/28 19:14:47」(JST)

wiki en

[Wiki en表示]

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

英文文献

  • TLR2- and 4-independent immunomodulatory effect of high molecular weight components from Ascaris suum.
  • Favoretto BC1, Silva SR2, Jacysyn JF3, Câmara NO4, Faquim-Mauro EL5.Author information 1Laboratory of Immunopathology, Butantan Institute, São Paulo, SP, Brazil.2Pasteur Institute, São Paulo, Brazil.3LIM62 Faculty of Medicine, University of São Paulo, São Paulo, Brazil.4Department of Immunology, University of São Paulo, São Paulo, Brazil.5Laboratory of Immunopathology, Butantan Institute, São Paulo, SP, Brazil. Electronic address: elianafaquim@butantan.gov.br.AbstractComponents of high molecular-weight (PI) obtained from Ascaris suum extract down-regulate the Th1/Th2-related immune responses induced by ovalbumin (OVA)-immunization in mice. Furthermore, the PI down-modulates the ability of dendritic cells (DCs) to activate T lymphocytes by an IL-10-mediated mechanism. Here, we evaluated the role of toll like receptors 2 and 4 (TLR2 and 4) in the modulatory effect of PI on OVA-specific immune response and the PI interference on DC full activation. An inhibition of OVA-specific cellular and humoral responses were observed in wild type (WT) or in deficient in TLR2 (TLR2(-/-)) or 4 (TLR4(-/-)) mice immunized with OVA plus PI when compared with OVA-immunized mice. Low expression of class II MHC, CD40, CD80 and CD86 molecules was observed in lymph node (LN) cells from WT, TLR2(-/-) or TLR4(-/-) mice immunized with OVA plus PI compared with OVA-primed cells. We also verified that PI was able to modulate the activation of DCs derived from bone marrow of WT, TLR2(-/-) or TLR4(-/-) mice induced in vitro by agonists of TLRs, as observed by a decreased expression of class II MHC and costimulatory molecules and by low secretion of pro-inflammatory cytokines. Its effect was accompanied by IL-10 synthesis. In this sense, the modulatory effect of PI on specific-immune response and DC activation is independent of TLR2 or TLR4.
  • Molecular immunology.Mol Immunol.2014 Mar;58(1):17-26. doi: 10.1016/j.molimm.2013.10.011. Epub 2013 Nov 19.
  • Components of high molecular-weight (PI) obtained from Ascaris suum extract down-regulate the Th1/Th2-related immune responses induced by ovalbumin (OVA)-immunization in mice. Furthermore, the PI down-modulates the ability of dendritic cells (DCs) to activate T lymphocytes by an IL-10-mediated mecha
  • PMID 24263181
  • Increased expression of herpesvirus entry mediator in 1,25‑dihydroxyvitamin D3‑treated mouse bone marrow‑derived dendritic cells promotes the generation of CD4+CD25+Foxp3+ regulatory T cells.
  • Huang Y1, Zhao Y2, Ran X2, Wang C1.Author information 1Institute of Respiratory Diseases, Xinqiao Hospital, The Third Military Medical University, Chongqing 430037, P.R. China.2Department of Respiratory Medicine, Second Affiliated Hospital, Chongqing Medical University, Chongqing 404000, P.R. China.AbstractDendritic cells (DCs) can initiate immune responses or induce immune tolerance. 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] is a secosteroid hormone that can induce tolerogenic dendritic cells favoring the induction of regulatory T cells (Treg). The present study revealed a tolerogenic effect of 1,25(OH)2D3 on the phenotype and function of ovalbumin (OVA)‑activated mouse bone marrow‑derived DCs. Three inhibitory molecules associated with tolerogenic DCs, programmed death‑ligand-1 (PD‑L1), PD‑L2 and herpesvirus entry mediator (HVEM) and the expression of co‑stimulatory molecules (CD80, CD86 and CD40) on 1,25(OH)2D3‑treated DCs were examined. The levels of interleukin (IL)‑2, IL‑6 and IL‑10 secreted by 1,25(OH)2D3‑treated DCs were analyzed. The capability of 1,25(OH)2D3‑treated DCs to induce CD4+CD25+Foxp3+ Treg and the stimulation of allogeneic CD4+ T‑cell proliferation in mixed lymphocyte reaction (MLR) was studied. 1,25(OH)2D3‑treated DCs induced up to 21.0‑fold upregulation of the HVEM expression and 4.1‑fold enhancement of the HVEM expression upon activation with OVA [OVA‑D3/immature (im)DCs]. PD‑L1 was not affected by 1,25(OH)2D3‑treated DCs and downregulated PD‑L2 expression on 1,25(OH)2D3‑treated DCs and OVA‑D3/imDC. The expression of co‑stimulatory molecules (CD80, CD86 and CD40) was downregulated in 1,25(OH)2D3‑treated DCs and OVA‑D3/imDC. Furthermore, 1,25(OH)2D3‑treated DCs secreted much higher levels of IL‑10, however lower levels of IL‑2 and IL‑6 compared with the activated control DCs. Together with this pattern of cytokines, 1,25(OH)2D3‑treated DCs exhibited low allogeneic CD4+ T‑cell stimulatory activity and a higher number of CD4+CD25+Foxp3+ cells in the MLR cultures but not in the activated control DCs. These findings indicate that 1,25(OH)2D3 possesses the immunosuppressive properties by upregulating the expression of the inhibitory molecules, HVEM, which may be therapeutically useful in controlling chronic immune and/or inflammatory diseases.
  • Molecular medicine reports.Mol Med Rep.2014 Mar;9(3):813-8. doi: 10.3892/mmr.2013.1874. Epub 2013 Dec 18.
  • Dendritic cells (DCs) can initiate immune responses or induce immune tolerance. 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] is a secosteroid hormone that can induce tolerogenic dendritic cells favoring the induction of regulatory T cells (Treg). The present study revealed a tolerogenic effect of 1,25(
  • PMID 24366217
  • Glucocorticoid inhibition of activation-induced cytidine deaminase expression in human B lymphocytes.
  • Benko AL1, Olsen NJ2, Kovacs WJ3.Author information 1Division of Endocrinology, Diabetes, and Metabolism, The Pennsylvania State University, College of Medicine, Milton S. Hershey Medical Center, Hershey, PA 17033, United States.2Division of Rheumatology, The Pennsylvania State University, College of Medicine, Milton S. Hershey Medical Center, Hershey, PA 17033, United States.3Division of Endocrinology, Diabetes, and Metabolism, The Pennsylvania State University, College of Medicine, Milton S. Hershey Medical Center, Hershey, PA 17033, United States. Electronic address: wkovacs@hmc.psu.edu.AbstractWe examined whether glucocorticoids could modulate the expression of activation-induced cytidine deaminase (AICDA), the principal regulator of the processes of immunoglobulin gene somatic hypermutation and class switch recombination in B lymphocytes. Treatment of human B cells with IL-4 and anti-CD40 antibody for 18-20h resulted in induction of expression of AICDA mRNA by over 10-fold. Dexamethasone at 10nM concentration inhibited AICDA induction by an average of 51.8% (p<0.0001). These effects of glucocorticoids were found to be dose dependent in the physiologic range and were reversible by co-treatment with a glucocorticoid receptor antagonist. Human B cell viability and proliferation were unaltered by glucocorticoid treatment. These data demonstrate that physiologic concentrations of glucocorticoids can act on human B lymphocytes through glucocorticoid receptor-mediated mechanisms to diminish the expression of AICDA, a key regulator of humoral immune responses.
  • Molecular and cellular endocrinology.Mol Cell Endocrinol.2014 Feb 15;382(2):881-7. doi: 10.1016/j.mce.2013.11.001. Epub 2013 Nov 15.
  • We examined whether glucocorticoids could modulate the expression of activation-induced cytidine deaminase (AICDA), the principal regulator of the processes of immunoglobulin gene somatic hypermutation and class switch recombination in B lymphocytes. Treatment of human B cells with IL-4 and anti-CD4
  • PMID 24239615

和文文献

  • シンポジウム「統合医科学研究所(TIIMS)の紹介と今後の展望」(2)関節リウマチの遺伝子解析
  • 谷口 敦夫
  • 東京女子医科大学雑誌 81(3), 198-203, 2011-06-25
  • … MHC領域、T細胞活性化やCD40シグナル伝達に関与する分子の遺伝子多型などが遺伝的リスク要因として報告されている。 …
  • NAID 110008585264
  • Allogenic mixed chimerism prevented autoimmune thrombocytopenia in BXSB lupus mice receiving donor BMT with nonlymphoablative conditioning of low-dose TBI and anti-CD40L mAb
  • Takeuchi Emiko
  • The Kitasato medical journal 41(1), 50-56, 2011-03
  • NAID 40018724980

関連リンク

CD40 【成熟 B細胞】 CD40抗原は糖鎖付加したリン酸化タンパクです。腫瘍壊死因子レセプタ(TNFR)スーパーファミリーのひとつで、4個所のシスティンに富んだ繰り返し部分があります。分子量は約44-48kDaです。すべての成熟Bリンパ球 ...
共刺激分子(副刺激分子:補助受容体)として、CD28や、CD152(CTLA-4)、CD40 などと言う、インテグリン(受容体)が、T細胞表面に発現される。 インテグリン(共刺激分子:補助受容体)は、対応するリガンド(補助刺激 ...

関連画像

 - GeneGlobe Pathways - CD40 SignalingCD40. Causes, symptoms, treatment CD40Pathway Central: CD40 SignalingCD40. Causes, symptoms, treatment CD40 DEL PATHWAY CD40/SCD40 IN EMODIALISI Pros and cons of artificial CD40 triggers


★リンクテーブル★
リンク元表面抗原分類」「高IgM症候群」「サイトカイン受容体」「CD154」「CD40抗原
関連記事CD」「CD4

表面抗原分類」

  [★]

cluster of differentiation, CD
  • 細胞の表面抗原を認識する抗体を整理した分類
Bリンパ球 CD10,CD19,CD20
Tリンパ球 CD2,CD3,CD5,CD7
幹細胞 CD34
顆粒球 CD13,CD33
単球 CD14:LPSをリガンドとし、Toll-like receptorと共役して細胞内シグナルを伝達する分子。
巨核球 CD41(GpIIb),CD42(GpIb)
NK細胞CD16(IgGのFc部に対する受容体)、CD56(NCAM-I)


CD1 CD21 CD41 CD61 CD81
CD2 CD22 CD42 CD62 CD82
CD3 CD23 CD43 CD63 CD83
CD4 CD24 CD44 CD64 CD84
CD5 CD25 CD45 CD65 CD85
CD6 CD26 CD46 CD66 CD86
CD7 CD27 CD47 CD67 CD87
CD8 CD28 CD48 CD68 CD88
CD9 CD29 CD49 CD69 CD89
CD10 CD30 CD50 CD70 CD90
CD11 CD31 CD51 CD71 CD91
CD12 CD32 CD52 CD72 CD92
CD13 CD33 CD53 CD73 CD93
CD14 CD34 CD54 CD74 CD94
CD15 CD35 CD55 CD75 CD95
CD16 CD36 CD56 CD76 CD96
CD17 CD37 CD57 CD77 CD97
CD18 CD38 CD58 CD78 CD98
CD19 CD39 CD59 CD79 CD99
CD20 CD40 CD60 CD80 CD100


高IgM症候群」

  [★]

hyper-IgM syndrome HIMS, hyper-IgM syndrome HIGM
IgM増加を伴う抗体欠乏症


  • IgM高値, IgG/IgA低値、胚中心欠損

原因遺伝子

avtivation-induced cytosine deaminase
RNA editing enzyme

概念

病型

  • 高IgM症候群1型 HIGM1
  • 高IgM症候群2型 HIGM2
  • 高IgM症候群3型 HIGM3

遺伝

  • X連鎖劣性遺伝
多くの場合。男児のみ。
遺伝子座:Xq28
  • 常染色体劣性遺伝

病因

  • 免疫グロブリンのクラススイッチ機構の異常→IgM産生可能。IgG、IgA、IgE産生不可
  • X連鎖劣性遺伝
  • 活性化T細胞上のCD40リガンド(CD154)の遺伝子異常→CD40シグナルを介したB細胞のクラススイッチがおきない
  • 常染色体劣性遺伝

疫学

症状

  • XLAと同じく化膿菌の易感染性
  • 細胞性免疫不全によるカリニ肺炎の発症

診断

  • 血清免疫グロブリン値の検査値
  • X連鎖劣性遺伝のものでは、活性化T細胞のCD154分子の有無をフローサイトメトリーで分析
  • 確定診断:CD154またはAID遺伝子解析

検査

  • 血清IgMは正常または高値
  • 血清IgG、IgA、IgEは低値
  • 一部の症例では好中球減少

治療

  • 免疫グロブリン置換療法
  • カリニ肺炎の治療・予防→ST合剤の内服
  • 造血幹細胞移植

予後

予防

サイトカイン受容体」

  [★]

cytokine receptor
サイトカイン
  • 多ユニット構造を取ることが特徴である。

サイトカイン受容体ファミリー

  • 細胞外領域に200a.a.からなる共通構造を有する。
  • HRF motif, hematopoietin receptor family motif
  • 細胞外領域のN末側に4つのCysが存在
  • 細胞外領域の膜貫通部位付近にWSXWSモチーフが存在
shared γc IL-2, IL-4, IL-7, IL-9, IL-13, IL-15
shared gp130 IL-6, G-CSF, IL-11, IL-12, LIF, OSM, CNTF
shared gp140 IL-3, IL-5, GM-CSF

チロシンキナーゼファミリー

IL-1受容体ファミリー

TNF受容体ファミリー

ケモカイン受容体ファミリー


CD154」

  [★]

CD40LTRAP、T-BAM、gp39, CD40 ligand, (CD40L:CD154)
CD

発現細胞

  • activeted CD4 T cell

機能

  • CD40のリガンド
  • B細胞の増殖
  • B細胞の活性化
  • B細胞のクラススイッチ促進(isotype switching)

臨床関連

  • 欠損


CD40抗原」

  [★]

CD40 antigenCD40
CD40タンパク質


CD」

  [★]

PrepTutorEJDIC   license prepejdic

「certificate of deposit / (また『C.D.』)Civil Defense民間防衛」


CD4」

  [★]

T4, Leucine-SA, Leucine-3B
表面抗原分類



"http://meddic.jp/CD40" より作成


★コメント★

[メモ入力エリア]
※コメント5000文字まで
ニックネーム:
コメント:




表示
個人用ツール


  meddic.jp

リンク
連絡