C1s

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補体, C1

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2012/09/19 13:05:29」(JST)

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英文文献

  • Scube2 enhances proteolytic Shh processing from the surface of Shh-producing cells.
  • Jakobs P1, Exner S, Schürmann S, Pickhinke U, Bandari S, Ortmann C, Kupich S, Schulz P, Hansen U, Seidler DG, Grobe K.Author information 1The Institute for Physiological Chemistry and Pathobiochemistry, Westfälische Wilhelms Universität Münster, Waldeyerstrasse 15, D-48149 Münster, Germany.AbstractAll morphogens of the Hedgehog (Hh) family are synthesized as dual-lipidated proteins, which results in their firm attachment to the surface of the cell in which they were produced. Thus, Hh release into the extracellular space requires accessory protein activities. We suggested previously that the proteolytic removal of N- and C-terminal lipidated peptides (shedding) could be one such activity. More recently, the secreted glycoprotein Scube2 (signal peptide, cubulin domain, epidermal-growth-factor-like protein 2) was also implicated in the release of Shh from the cell membrane. This activity strictly depended on the CUB domains of Scube2, which derive their name from the complement serine proteases and from bone morphogenetic protein-1/tolloid metalloproteinases (C1r/C1s, Uegf and Bmp1). CUB domains function as regulators of proteolytic activity in these proteins. This suggested that sheddases and Scube2 might cooperate in Shh release. Here, we confirm that sheddases and Scube2 act cooperatively to increase the pool of soluble bioactive Shh, and that Scube2-dependent morphogen release is unequivocally linked to the proteolytic processing of lipidated Shh termini, resulting in truncated soluble Shh. Thus, Scube2 proteins act as protease enhancers in this setting, revealing newly identified Scube2 functions in Hh signaling regulation.
  • Journal of cell science.J Cell Sci.2014 Apr 15;127(Pt 8):1726-37. doi: 10.1242/jcs.137695. Epub 2014 Feb 12.
  • All morphogens of the Hedgehog (Hh) family are synthesized as dual-lipidated proteins, which results in their firm attachment to the surface of the cell in which they were produced. Thus, Hh release into the extracellular space requires accessory protein activities. We suggested previously that the
  • PMID 24522195
  • Possibility of graphene growth by close space sublimation.
  • Sopinskyy MV1, Khomchenko VS, Strelchuk VV, Nikolenko AS, Olchovyk GP, Vishnyak VV, Stonis VV.Author information 1V, Ye, Lashkaryov Institute of Semiconductor Physics, National Academy of Sciences of Ukraine, 45 Prospect Nauky, Kyiv 03028, Ukraine. sopinsky@isp.kiev.ua.AbstractCarbon films on the Si/SiO2 substrate are fabricated using modified method of close space sublimation at atmospheric pressure. The film properties have been characterized by micro-Raman and X-ray photoelectron spectroscopy and monochromatic ellipsometry methods. Ellipsometrical measurements demonstrated an increase of the silicon oxide film thickness in the course of manufacturing process. The XPS survey spectra of the as-prepared samples indicate that the main elements in the near-surface region are carbon, silicon, and oxygen. The narrow-scan spectra of C1s, Si2p, O1s regions indicate that silicon and oxygen are mainly in the SiOx (x ≈ 2) oxide form, whereas the main component of C1s spectrum at 284.4 eV comes from the sp2-hybridized carbon phase. Micro-Raman spectra confirmed the formation of graphene films with the number of layers that depended on the distance between the graphite source and substrate.
  • Nanoscale research letters.Nanoscale Res Lett.2014 Apr 14;9(1):182. doi: 10.1186/1556-276X-9-182.
  • Carbon films on the Si/SiO2 substrate are fabricated using modified method of close space sublimation at atmospheric pressure. The film properties have been characterized by micro-Raman and X-ray photoelectron spectroscopy and monochromatic ellipsometry methods. Ellipsometrical measurements demonstr
  • PMID 24731549
  • TNT003, an inhibitor of the serine protease C1s, prevents complement activation induced by cold agglutinin disease patient autoantibodies.
  • Shi J1, Rose EL, Singh A, Hussain S, Stagliano NE, Parry GC, Panicker S.Author information 1True North Therapeutics, Inc., South San Francisco, CA, United States.AbstractActivation of the classical pathway of complement (CP) is often associated with autoimmune disorders in which disease pathology is linked to the presence of an autoantibody. One such disorder is cold agglutinin disease (CAD), an autoimmune hemolytic anemia in which autoantibodies (cold agglutinins) bind to red blood cells (RBCs) at low temperatures. Anemia occurs as a result of autoantibody mediated CP activation on the surface of the erythrocyte, leading to the deposition of complement opsonins that drive extravascular hemolysis in the liver. Here we test the effects of TNT003, a mouse monoclonal antibody targeting the CP specific serine protease C1s, on CP activity induced by cold agglutinins on human RBCs. We collected 40 individual CAD patient samples and showed that TNT003 prevented cold agglutinin mediated deposition of complement opsonins that promote phagocytosis of RBCs. Furthermore, by preventing CP activation, we show TNT003 also prevents cold agglutinin driven generation of anaphylatoxins. Finally, we provide evidence that CP activity in CAD patients terminates prior to activation of the terminal cascade, supporting the hypothesis that the primary route of RBC destruction in these patients occurs via extravascular hemolysis. Our results support the development of a CP inhibitor for the treatment of CAD.
  • Blood.Blood.2014 Apr 2. [Epub ahead of print]
  • Activation of the classical pathway of complement (CP) is often associated with autoimmune disorders in which disease pathology is linked to the presence of an autoantibody. One such disorder is cold agglutinin disease (CAD), an autoimmune hemolytic anemia in which autoantibodies (cold agglutinins)
  • PMID 24695853

和文文献

  • 計算化学を用いたX線光電子分光分析による炭素材料の構造解析
  • スパッタリング法で調製した炭素-白金電極触媒のメタノール酸化反応選択性に及ぼすポストアニールの 影響
  • SiC(0001)基板に成長させたゼロ層グラフェンへの銅インターカレーション

関連画像

芭蕾雨·悦都C1s户型乐视盒子C1S明日预售 学小米 Toyo C1S FX-3 Super 2000”vs“COSINA C1s Training Fleet Of 12 Diamond DA20-C1sProxes C1S


★リンクテーブル★
リンク元補体
拡張検索補体C1s」「C1s欠損症」「complement C1s
関連記事C」「C1

補体」

  [★]

complement
アレキシン alexin
補体活性化経路補体価


  • 図:IMM.63
pathway start first step
classical pathway antigen-antibody complex C1q, C1r, C1s, C4, C2
lectin pathway mannose-binding lectin or ficolin binds carbohydrate on pathogen surface MBL/ficolin, MASP-2, C4, C2
alternative pathway pathogen surface C3, B, D

補体の相互作用 IMM.62

  • C1qがカスケードの最初となる。3つの方法で補体カスケードがはじまる。
  • (1)多価陰イオン表面(例えば、グラム陰性細菌のリポテイコ酸)
  • (2)バクテリアの多糖のホスホコリンに結合(例えば肺炎球菌のC蛋白質)
  • (3)抗原抗体複合体に結合して自然免疫と獲得免疫のエフェクター機構を結びつける。
  • 炭化水素鎖を認識するレクチンがカスケードの最初となる。
  • C3からはじまる。血漿中のC3が病原体の表面で自発的に活性化されることで補体反応がはじまる。
3つの経路は共通してC3 convertaseを生成。C3 convertaseはC3→C3a+C3b
C3a: C3a is a peptide mediator of local inflammation
C3b: C3b binds covalently to the bacterial cell membrane and opsonizes the bacteria
C5 convertaseはC3bにC3 convertaseが結合してできる
C5 converaseはC5→C5a+C5b
C5a: powerful peptide mediator of inflammation
C5b: C5b,C6,C7,C8,C9: membrane-attack complex

C3aとC5a。C4a

炎症部位に血管外に抗体、補体、食細胞を集め、組織液を増やすことで抗原提示細胞がリンパ節に移動するのを促進する(IMM.75)
  • C5a,C3a,C4a: smooth muscle contraction.(IMM.75)
  • C5a,C3a: act on the endo thelial cells lining blood vessels to induce adhesion molecules.(IMM.75)
  • C5a>C3a>C4a: increase in blood flow, increase vascular permeability, increase binding of phagocytes to exdothielial cells.(IMM.76)
  • C5a: activates mast cells to release mediators, such as histamine and TNF-α. that contribute the inflammatory response(IMM.76).
  • C5a: acts directly on neutrophils and monocytes and attracting neutrophils and monocytes(IMM.75)
  • C3a: contributes to the pypotension and edema seen in endotoxic shock
  • C5a: activated by endotoxin, funcions in neutrophil chemotaxis

C5a

臨床関連

  • 増加:



補体C1s」

  [★]

complement C1sC1s complement


C1s欠損症」

  [★]

C1s deficiency
C1s


complement C1s」

  [★]

補体C1s

C1s complement


C」

  [★]

WordNet   license wordnet

「the 3rd letter of the Roman alphabet」
c

WordNet   license wordnet

「(music) the keynote of the scale of C major」

WordNet   license wordnet

「a general-purpose programing language closely associated with the UNIX operating system」

PrepTutorEJDIC   license prepejdic

「carbonの化学記号」


C1」

  [★]



"http://meddic.jp/C1s" より作成


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