出典: meddic


  • The Value of Signal Peptide-CUB-EGF Domain-containing Protein-1 (SCUBE1) in the Diagnosis of Pulmonary Embolism: A Preliminary Study.
  • Turkmen S1, Sahin A1, Gunaydin M2, Sahin S3, Mentese A4, Turedi S1, Karahan SC4, Ozsu S5, Gunduz A1.
  • Academic emergency medicine : official journal of the Society for Academic Emergency Medicine.Acad Emerg Med.2015 Aug;22(8):922-6. doi: 10.1111/acem.12721. Epub 2015 Jul 22.
  • OBJECTIVES: The diagnosis of pulmonary embolism (PE) in the emergency department still poses difficulties because symptoms and signs are nonspecific. There is a need for more reliable noninvasive diagnostic tests to support clinical suspicion before the costly invasive procedures with complication r
  • PMID 26202675
  • Characterization of rock bream (Oplegnathus fasciatus) complement components C1r and C1s in terms of molecular aspects, genomic modulation, and immune responsive transcriptional profiles following bacterial and viral pathogen exposure.
  • Godahewa GI1, Bathige SD1, Herath HM1, Noh JK2, Lee J3.
  • Fish & shellfish immunology.Fish Shellfish Immunol.2015 Aug 1;46(2):656-668. doi: 10.1016/j.fsi.2015.07.026. [Epub ahead of print]
  • The complement components C1r and C1s play a crucial role in innate immunity via activation of the classical complement cascade system. As initiators of the pathogen-induced signaling cascade, C1r and C1s modulate innate immunity. In order to understand the immune responses of teleost C1r and C1s, O
  • PMID 26241508


  • Roles of CUB and LDL receptor class A domain repeats of a transmembrane serine protease matriptase in its zymogen activation.
  • Inouye Kuniyo,Tomoishi Marie,Yasumoto Makoto [他],Miyake Yuka,Kojima Kenji,Tsuzuki Satoshi,Fushiki Tohru
  • Journal of biochemistry 153(1), 51-61, 2013-01
  • … Matriptase is a type II transmembrane serine protease containing two complement proteases C1r/C1s-urchin embryonic growth factor-bone morphogenetic protein domains (CUB repeat) and four low-density lipoprotein receptor class A domains (LDLRA repeat). …
  • NAID 120005373084
  • Identification of cDNA Sequences Encoding the Complement Components of Zebrafish (Danio rerio)
  • Vo Kha Tam,Tsujikura Masakazu,Somamoto Tomonori,Nakano Miki
  • Journal of the Faculty of Agriculture, Kyushu University 54(2), 373-387, 2009-10-29
  • … Complementary DNA sequences encoding C1q, C1r/s, C2 (B/C2-B), C3, C4, C5, C6, C7, C8, C9, factor B (B/C2-A), the mannose-binding lectin (MBL), two MBL-associated serine proteases, properdin, and factor I were identified by cloning from the hepatopancreas and by database mining. …
  • NAID 120001766563




拡張検索C1r complement」「C1r欠損症



アレキシン alexin

  • 図:IMM.63
pathway start first step
classical pathway antigen-antibody complex C1q, C1r, C1s, C4, C2
lectin pathway mannose-binding lectin or ficolin binds carbohydrate on pathogen surface MBL/ficolin, MASP-2, C4, C2
alternative pathway pathogen surface C3, B, D

補体の相互作用 IMM.62

  • C1qがカスケードの最初となる。3つの方法で補体カスケードがはじまる。
  • (1)多価陰イオン表面(例えば、グラム陰性細菌のリポテイコ酸)
  • (2)バクテリアの多糖のホスホコリンに結合(例えば肺炎球菌のC蛋白質)
  • (3)抗原抗体複合体に結合して自然免疫と獲得免疫のエフェクター機構を結びつける。
  • 炭化水素鎖を認識するレクチンがカスケードの最初となる。
  • C3からはじまる。血漿中のC3が病原体の表面で自発的に活性化されることで補体反応がはじまる。
3つの経路は共通してC3 convertaseを生成。C3 convertaseはC3→C3a+C3b
C3a: C3a is a peptide mediator of local inflammation
C3b: C3b binds covalently to the bacterial cell membrane and opsonizes the bacteria
C5 convertaseはC3bにC3 convertaseが結合してできる
C5 converaseはC5→C5a+C5b
C5a: powerful peptide mediator of inflammation
C5b: C5b,C6,C7,C8,C9: membrane-attack complex


  • C5a,C3a,C4a: smooth muscle contraction.(IMM.75)
  • C5a,C3a: act on the endo thelial cells lining blood vessels to induce adhesion molecules.(IMM.75)
  • C5a>C3a>C4a: increase in blood flow, increase vascular permeability, increase binding of phagocytes to exdothielial cells.(IMM.76)
  • C5a: activates mast cells to release mediators, such as histamine and TNF-α. that contribute the inflammatory response(IMM.76).
  • C5a: acts directly on neutrophils and monocytes and attracting neutrophils and monocytes(IMM.75)
  • C3a: contributes to the pypotension and edema seen in endotoxic shock
  • C5a: activated by endotoxin, funcions in neutrophil chemotaxis



  • 増加:

C1r complement」



complement C1r



C1r deficiency



WordNet   license wordnet

「the 3rd letter of the Roman alphabet」

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「(music) the keynote of the scale of C major」

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「a general-purpose programing language closely associated with the UNIX operating system」

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