WordNet

write by means of a keyboard with types; "type the acceptance letter, please" (同)typewrite
a small metal block bearing a raised character on one end; produces a printed character when inked and pressed on paper; "he dropped a case of type, so they made him pick them up"
(biology) the taxonomic group whose characteristics are used to define the next higher taxon
a subdivision of a particular kind of thing; "what type of sculpture do you prefer?"
all of the tokens of the same symbol; "the word `element contains five different types of character"
printed characters; "small type is hard to read"
identify as belonging to a certain type; "Such people can practically be typed" (同)typecast
the 3rd letter of the Roman alphabet (同)c
(music) the keynote of the scale of C major
a general-purpose programing language closely associated with the UNIX operating system
amide combining the amino group of one amino acid with the carboxyl group of another; usually obtained by partial hydrolysis of protein
of or relating to natriuresis
writing done with a typewriter (同)typewriting

PrepTutorEJDIC

〈C〉(…の)『型』,タイプ,類型,種類(kind)《+of+名》 / 〈C〉(その種類の特質を最もよく表している)『典型』,手本,模範《+of+名》 / 〈U〉《集合的に》活字;〈C〉(1個の)活字 / 〈U〉(印刷された)字体,活字 / 〈C〉(貨幣・メダルなどの)模様,図柄 / 〈C〉血液型(blood group) / …‘を'タイプに打つ / (…として)…‘を'分類する《+名+as+名(doing)》 / …‘の'型を決める / タイプライターを打つ
carbonの化学記号

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/09/17 05:28:19」(JST)

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Natriuretic peptide precursor C, also known as NPPC, is a protein that in humans is encoded by the NPPC gene.^[1]^[2]^[3] The precursor NPPC protein is cleaved to the 22 amino acid peptide C-type natriuretic peptide (CNP).

Function

Natriuretic peptides comprise a family of 3 structurally related molecules: atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and C-type natriuretic peptide, CNP, encoded by a gene symbolized NPPC. These peptides possess potent natriuretic, diuretic, and vasodilating activities and are implicated in body fluid homeostasis and blood pressure control.^[1] Unlike ANP and BNP, CNP does not have direct natriuretic activity. This is because CNP is a selective agonist for the B-type natriuretic receptor (NPRB) whereas ANP and BNP are selective for NPRA.^[4]

Structure of C-type natriuretic peptide (human)

References

^ ^a ^b "Entrez Gene: NPPC natriuretic peptide precursor C".
^ Kaneko T, Shirakami G, Nakao K, Nagata I, Nakagawa O, Hama N, Suga S, Miyamoto S, Kubo H, Hirai O (May 1993). "C-type natriuretic peptide (CNP) is the major natriuretic peptide in human cerebrospinal fluid". Brain Res. 612 (1–2): 104–9. doi:10.1016/0006-8993(93)91649-D. PMID 8330189.
^ Ogawa Y, Itoh H, Yoshitake Y, Inoue M, Yoshimasa T, Serikawa T, Nakao K (November 1994). "Molecular cloning and chromosomal assignment of the mouse C-type natriuretic peptide (CNP) gene (Nppc): comparison with the human CNP gene (NPPC)". Genomics 24 (2): 383–7. doi:10.1006/geno.1994.1633. PMID 7698765.
^ Barr CS, Rhodes P, Struthers AD (1996). "C-type natriuretic peptide". Peptides 17 (7): 1243–51. doi:10.1016/S0196-9781(96)00110-6. PMID 8959763.

External links

C-Type Natriuretic Peptide at the US National Library of Medicine Medical Subject Headings (MeSH)

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it.

UpToDate Contents

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1. 心不全におけるナトリウム利尿ペプチド測定 natriuretic peptide measurement in heart failure
2. 非心不全下におけるナトリウム利尿ペプチド測定 natriuretic peptide measurement in non heart failure settings
3. 脳卒中のための血液バイオマーカー blood biomarkers for stroke
4. 非ST上昇型心筋梗塞後の有害転帰の危険因子 risk factors for adverse outcomes after non st elevation acute coronary syndromes
5. アミロイド心筋症の臨床症状および診断 clinical manifestations and diagnosis of amyloid cardiomyopathy

English Journal

Endogenous vascular synthesis of B-type and C-type natriuretic peptides in the rainbow trout.

Johnson KR, Hoagland TM, Olson KR.SourceUniversity of Notre Dame, Department of Biological Sciences, Notre Dame, IN 46556, USA.
The Journal of experimental biology.J Exp Biol.2011 Aug 15;214(Pt 16):2709-17.
In mammals, natriuretic peptides (NPs) lower blood pressure, reduce blood volume and broadly inhibit cardiovascular remodeling. NPs are often referred to as cardiac hormones, though they also have integral roles in regulating vascular tone, endothelial remodeling and inhibiting vascular smooth muscl
PMID 21795567

Plasma CNP Forms and Thyroid Status in Prepubertal Children with Acquired Thyroid Disease.

Reh CS, Olney R, Azen C, Prickett T, Espiner E, Geffner M.SourceCenter for Endocrinology, Diabetes, and Metabolism at Children's Hospital Los Angeles, Keck School of Medicine of USC, Los Angeles, CA Nemours Children's Clinic, Jacksonville, FL Saban Research Institute of Children's Hospital Los Angeles, Los Angeles, CA Department of Medicine, Christchurch School of Medicine and Health Sciences, University of Otago, Christchurch, New Zealand.
Clinical endocrinology.Clin Endocrinol (Oxf).2011 Aug 4. doi: 10.1111/j.1365-2265.2011.04187.x. [Epub ahead of print]
Objective:? C-type natriuretic peptide (CNP) and thyroid hormone (TH) are essential for normal skeletal growth. Plasma CNP peptides correlate with growth velocity, but the relationship between thyroid status and CNP production is unknown. This study examined the impact of restoring normal TH level
PMID 21815902

Japanese Journal

心房性ナトリウム利尿ペプチド(ANP),脳性ナトリウム利尿ペプチド(BNP),C型ナトリウム利尿ペプチド(CNP) (広範囲血液・尿化学検査免疫学的検査(第7版・4)その数値をどう読むか) -- (内分泌学的検査その他)

辻野元祥,平田結喜緒
日本臨床 68(-) (982), 619-622, 2010-07
NAID 40017200824

Preliminary Immunohistochemical Study of Natriuretic Peptide Receptor Localization in Canine and Feline Heart

YAMANE Tetsuya,TAKEMURA Naoyuki,INOUE Hajime,SOETA Satoshi,OISHI Motoharu,AMASAKI Hajime
Journal of Veterinary Medical Science advpub(0), 1010120361, 2010
… We examined the imunohistochemical distributions of natriuretic peptide receptor (NPR)-A, -B and -C that bind with natriatetic peptide hormones A, B and C using specific antibodies against human antigens in four healthy crossbreed young canine and feline cardiac tissues. … NPR-A and -C were expressed more strongly in dogs than cats. …
NAID 130000444258

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★リンクテーブル★

リンク元	「C型ナトリウム利尿ペプチド」
関連記事	「C」「type」「natriuretic」「typed」「typing」

「C型ナトリウム利尿ペプチド」

Natriuretic peptide C
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	1JDP
Identifiers
Symbols	NPPC ; CNP; CNP2
External IDs	OMIM: 600296 MGI: 97369 HomoloGene: 7867 GeneCards: NPPC Gene
Gene ontology
Molecular function	• receptor binding; • hormone activity; • protein homodimerization activity; • peptide hormone receptor binding;
Cellular component	• extracellular space; • secretory granule;
Biological process	• ossification; • response to hypoxia; • growth plate cartilage chondrocyte differentiation; • growth plate cartilage chondrocyte proliferation; • cGMP biosynthetic process; • receptor guanylyl cyclase signaling pathway; • negative regulation of cell proliferation; • post-embryonic development; • regulation of cAMP metabolic process; • regulation of cGMP metabolic process; • positive regulation of cGMP biosynthetic process; • regulation of multicellular organism growth; • response to drug; • single organism reproductive process; • response to ethanol; • positive regulation of osteoblast differentiation; • positive regulation of vasodilation; • regulation of smooth muscle cell proliferation; • regulation of blood vessel size; • negative regulation of DNA metabolic process; • negative regulation of meiotic cell cycle; • negative regulation of oocyte maturation;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
	v; t; e;