出典: meddic

Bruton's tyrosine kinase

Bruton tyrosine kinase
Bruton's tyrosine kinase

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/06/05 23:37:10」(JST)

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  • Bruton's tyrosine kinase inhibitors: lessons learned from bench-to-bedside (first) studies.
  • Ysebaert L1, Michallet AS.
  • Current opinion in oncology.Curr Opin Oncol.2014 Sep;26(5):463-8. doi: 10.1097/CCO.0000000000000114.
  • PURPOSE OF REVIEW: Targeted inhibitors of B-cell receptor signaling have emerged as the most promising therapeutic options against non-Hodgkin's lymphoma. The inhibitor agents that target Bruton's tyrosine kinase (BTK) have elicited particularly high enthusiasm given the unprecedented positive respo
  • PMID 25033375
  • Adaptor protein DOK3 promotes plasma cell differentiation by regulating the expression of programmed cell death 1 ligands.
  • Ou X1, Xu S2, Li YF1, Lam KP3.
  • Proceedings of the National Academy of Sciences of the United States of America.Proc Natl Acad Sci U S A.2014 Aug 5;111(31):11431-6. doi: 10.1073/pnas.1400539111. Epub 2014 Jul 22.
  • The adaptor Downstream-of-Kinase (DOK) 3 functions as a negative regulator and attenuates B-cell receptor-mediated calcium signaling. Although DOK3 is dispensable for early B-cell development, its role in plasma cell (PC) differentiation is unknown. Here, we show that Dok3(-/-) mice have increased p
  • PMID 25053811
  • Blockade of oncogenic IκB kinase activity in diffuse large B-cell lymphoma by bromodomain and extraterminal domain protein inhibitors.
  • Ceribelli M1, Kelly PN1, Shaffer AL1, Wright GW2, Xiao W1, Yang Y1, Mathews Griner LA3, Guha R3, Shinn P3, Keller JM3, Liu D3, Patel PR3, Ferrer M3, Joshi S4, Nerle S4, Sandy P4, Normant E4, Thomas CJ3, Staudt LM5.
  • Proceedings of the National Academy of Sciences of the United States of America.Proc Natl Acad Sci U S A.2014 Aug 5;111(31):11365-70. doi: 10.1073/pnas.1411701111. Epub 2014 Jul 21.
  • In the activated B-cell-like (ABC) subtype of diffuse large B-cell lymphoma (DLBCL), NF-κB activity is essential for viability of the malignant cells and is sustained by constitutive activity of IκB kinase (IKK) in the cytoplasm. Here, we report an unexpected role for the bromodomain and extraterm
  • PMID 25049379


  • Anti-allergic Properties of a Fruit Extract of Prune (Prunus domestica L.) in Mite-sensitized BALB/c Mice
  • Food Science and Technology Research 18(5), 755-760, 2012
  • … Expression levels of Stat6, Btk and Stim1 mRNAs in spleen cells of mice given the extract-added diet were significantly lower than in mice given the extract-free diet. …
  • NAID 130002538083
  • 病原性真菌Candida albicans菌体外多糖CAWSによって惹起される血管炎に関する研究
  • 三浦 典子
  • Medical Mycology Journal 53(1), 25-31, 2012
  • … water soluble fraction)は,マウスに対して血管炎誘発活性を持つ.このCAWS血管炎は,マウスの系統によりその感受性が大きく異なる.そこでCAWS血管炎抵抗性のCBA/Jと,CBA/Jと同じ起源でありBruton's tyrosine kinase(Btk)を欠損したCBA/Nを用いて,CAWS血管炎の発症や抑制に関わる因子について検討した.その結果,CBA/Jでは内在性マトリックスメタロプロテアーゼ阻害剤であるTIMP1産生が観察された.また,種々のPAMPs刺激によ …
  • NAID 130001921797
  • Genetic analysis of contiguous X-chromosome deletion syndrome encompassing the BTK and TIMM8A genes
  • ARAI Takashi,ZHAO Meina,KANEGANE Hirokazu,VAN ZELM Menno C,FUTATANI Takeshi,YAMADA Masafumi,ARIGA Tadashi,OCHS Hans D,MIYAWAKI Toshio,OH-ISHI Tsutomu
  • Journal of human genetics 56(8), 577-582, 2011-08-01
  • NAID 10030660427




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  • Btk



  • Mg2+存在下でC3, B, Dが反応してC3bBbとなり、これがC3転換酵素(C3bBb)あるいはC5転換酵素(C3bBb3b)を形成する。これらはP(properdin)と結合して活性化し、それぞれC3、C5を活性化する

WordNet   license wordnet

「the 2nd letter of the Roman alphabet」

WordNet   license wordnet

「the blood group whose red cells carry the B antigen」
type B, group B

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