B-cell lymphocyte protein-2

出典: meddic


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  • Cellular STAT3 Functions via PCBP2 To Restrain Epstein-Barr Virus Lytic Activation in B Lymphocytes.
  • Koganti S1, Clark C1, Zhi J2, Li X1, Chen EI3, Chakrabortty S4, Hill ER1, Bhaduri-McIntosh S5.
  • Journal of virology.J Virol.2015 May 1;89(9):5002-11. doi: 10.1128/JVI.00121-15. Epub 2015 Feb 25.
  • A major hurdle to killing Epstein-Barr virus (EBV)-infected tumor cells using oncolytic therapy is the presence of a substantial fraction of EBV-infected cells that does not support the lytic phase of EBV despite exposure to lytic cycle-promoting agents. To determine the mechanism(s) underlying this
  • PMID 25717101
  • Chimerically fused antigen rich of overlapped epitopes from latent membrane protein 2 (LMP2) of Epstein-Barr virus as a potential vaccine and diagnostic agent.
  • Lin X1, Chen S1, Xue X1, Lu L1, Zhu S1, Li W1, Chen X1, Zhong X1, Jiang P1, Sename TS1, Zheng Y2, Zhang L1.
  • Cellular & molecular immunology.Cell Mol Immunol.2015 Apr 13. doi: 10.1038/cmi.2015.29. [Epub ahead of print]
  • Epstein-Barr virus (EBV) is prevalent throughout the world and is associated with several malignant diseases in humans. Latent membrane protein 2 (LMP2) of EBV plays a crucial role in the pathogenesis of EBV-associated tumors; therefore, LMP2 has been considered to be a potential immunodiagnostic an
  • PMID 25864917
  • SLy2 controls the antibody response to pneumococcal vaccine through an IL-5Rα-dependent mechanism in B-1 cells.
  • Schmitt F1, Schäll D, Bucher K, Schindler TI, Hector A, Biedermann T, Zemlin M, Hartl D, Beer-Hammer S.
  • European journal of immunology.Eur J Immunol.2015 Jan;45(1):60-70. doi: 10.1002/eji.201444882. Epub 2014 Nov 13.
  • The adaptor protein SLy2 (Src homology domain 3 lymphocyte protein 2) is located on human chromosome 21 and was reported to be among a group of genes amplified in Down's syndrome (DS) patients. DS patients characteristically show an impaired immunity to pneumococcal infections. However, molecular me
  • PMID 25330943


1. J Biol Chem. 2011 Apr 15;286(15):13489-501. doi: 10.1074/jbc.M110.155184. Epub 2011 Feb 4. Immunoinhibitory adapter protein Src homology domain 3 lymphocyte protein 2 (SLy2) regulates actin dynamics and B cell spreading.
・病原体などが体内に侵入した場合、それをマクロファージなどが貪食し、 抗原(敵であることを識別できる部分)を細胞表面に提示すると、それに 接触したBリンパ球のうち適合するレセプターを持ったBリンパ球が活性


Differentiation and function of Foxp3  protein function in lymphocyte development guides the fate of effector B and T cellsCalcium, Channels, Intracellular Signaling  /MHC-II on an activated B-LymphocyteBox 2 | T cell receptor signalling and the




bcl-2 gene, bcl-2遺伝子, bcl2遺伝子
bcl-1, bcl-2, bcl-3, bcl-6
  • IMM. 809
  • B細胞白血病では、染色体の転座により発癌性がもたらされているが、その転座の切断点がbcl-2遺伝子上にある。
  • bclはB-cell lymphoma/B-cell leukemiaの略
  • 癌遺伝子
  • ミトコンドリアの膜に結合してアポトーシスを防ぐ ← ミトコンドリア外膜の透過性亢進抑制


  • ミトコンドリア膜、小胞体

follicular lymphomaとの関連

  • 転座により免疫グロブリン遺伝子がbcl-2遺伝子とつながることでBcl-2の発現が増加。Bcl-2蛋白がB細胞系統のアポトーシスを抑制 (IMM.312)


  [★] 細胞

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「small room in which a monk or nun lives」

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「a device that delivers an electric current as the result of a chemical reaction」
electric cell

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「a room where a prisoner is kept」
jail cell, prison cell

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「(biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals」

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「any small compartment; "the cells of a honeycomb"」

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「a small unit serving as part of or as the nucleus of a larger political movement」

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「(刑務所の)『独房』;(修道院の)小さい独居室 / (ミツバチの)みつ房,巣穴 / 小さい部屋 / 『細胞』 / 電池 / 花粉室 / (共産党などの)細胞」



  • Mg2+存在下でC3, B, Dが反応してC3bBbとなり、これがC3転換酵素(C3bBb)あるいはC5転換酵素(C3bBb3b)を形成する。これらはP(properdin)と結合して活性化し、それぞれC3、C5を活性化する

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「the 2nd letter of the Roman alphabet」

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「the blood group whose red cells carry the B antigen」
type B, group B


  [★] 蛋白質

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「any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"」

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  [★] リンパ球


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「an agranulocytic leukocyte that normally makes up a quarter of the white blood cell count but increases in the presence of infection」
lymph cell