3-hydroxysteroid dehydrogenase

出典: meddic


3-beta-hydroxysteroid dehydrogenase

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  • Preliminary evidence of altered steroidogenesis in women with Alzheimer's disease: Have the patients "OLDER" adrenal zona reticularis?
  • Vaňková M1, Hill M2, Velíková M3, Včelák J4, Vacínová G5, Dvořáková K6, Lukášová P7, Vejražková D8, Rusina R9, Holmerová I10, Jarolímová E11, Vaňková H12, Kancheva R13, Bendlová B14, Stárka L15.
  • The Journal of steroid biochemistry and molecular biology.J Steroid Biochem Mol Biol.2016 Apr;158:157-77. doi: 10.1016/j.jsbmb.2015.12.011. Epub 2015 Dec 15.
  • Alzheimer's disease (AD) represents more than half of total dementias. Various factors including altered steroid biosynthesis may participate in its pathophysiology. We investigated how the circulating steroids (measured by GC-MS and RIA) may be altered in the presence of AD. Sixteen women with AD a
  • PMID 26704533
  • Ovarian dysfunctions in adult female rat offspring born to mothers perinatally exposed to low doses of bisphenol A.
  • Santamaría C1, Durando M1, Muñoz de Toro M1, Luque EH1, Rodriguez HA2.
  • The Journal of steroid biochemistry and molecular biology.J Steroid Biochem Mol Biol.2016 Apr;158:220-30. doi: 10.1016/j.jsbmb.2015.11.016. Epub 2015 Dec 4.
  • The study of oral exposure to the environmental estrogen bisphenol A (BPA) during the perinatal period and its effects on ovarian functionality in adulthood has generated special interest. Thus, our objective was to investigate ovarian folliculogenesis and steroidogenesis in adult female rat offspri
  • PMID 26658420
  • The endocannabinoid 2-arachidonoylglycerol dysregulates the synthesis of proteins by the human syncytiotrophoblast.
  • Costa MA1, Fonseca BM2, Mendes A3, Braga J3, Teixeira NA2, Correia-da-Silva G4.
  • Biochimica et biophysica acta.Biochim Biophys Acta.2016 Mar;1861(3):205-12. doi: 10.1016/j.bbalip.2015.12.008. Epub 2015 Dec 15.
  • In recent years, endocannabinoids emerged as new players in various reproductive events. Recently, we demonstrated the involvement of 2-arachidonoylglycerol (2-AG) in human cytotrophoblast apoptosis and syncytialization. However, 2-AG impact in hormone production by the syncytiotrophoblast (hST) was
  • PMID 26698196


  • ペルオキシソーム局在型カルボニル還元酵素(DHRS4)の3-ヒドロキシステロイド酸化活性について
  • 遠藤 智史,前田 哲志,松永 俊之,原 明,田中 信忠,今村 順茂
  • 日本薬物動態学会年会講演要旨集 23(0), 343-343, 2008
  • NAID 130005024443
  • Effects of Ovarian Theca Cells on Granulosa Cell Differentiation During Gonadotropin-Independent Follicular Growth in Cattle
  • Orisaka Makoto,Mizutani Tetsuya,Tajima Kimihisa,Orisaka Sanae,Shukunami Ken-ichi,Miyamoto Kaoru,Kotsuji Fumikazu
  • Molecular Reproduction and Development 73(6), 737-744, 2006-03
  • … Messenger RNA levels for P450 aromatase (aromatase), P450 cholesterol side chain cleavage (P450scc), 3-hydroxysteroid dehydrogenase (3-HSD), LH receptor (LHr), and steroidogenic acute regulatory protein (StAR) in granulosa cells were measured by real-time quantitative RT-PCR analysis. … Theca cells did not alter progesterone production and mRNA expression in granulosa cells for P450scc, 3-HSD, LHr, and StAR. …
  • NAID 120000807676
  • 原発性アルドステロン症に対するTrilostane (MWD-1822) の効果
  • 重富 秀一 [他],福地 総逸,春山 和見,山崎 正明
  • 日本内分泌学会雑誌 58(3), 184-198, 1982
  • … patients with primary aldosteronism (PA), one with idiopathic hyperaldosteronism (IHA), one with glucocorticoid responsible hyperaldosteronism (GRHA) and eight with essential hypertension (EH) were treated with trilostane (MWD-1822) (4α, 5-epoxy-17β-hydroxy-3-oxo-5α-androstane-2α-carbonitrile), an inhibitor of adrenal steroid biosynthesis, for 9-47 days with a daily dose of 30-960mg.<BR>Blood pressure decreased slightly and gradually from 30 min. to 360 min, plasma aldosterone (PAC) and cortisol concentration (F) decreased, and plasma …
  • NAID 130001938052


3-Beta-Hydroxysteroid Dehydrogenase Deficiency. 3-beta–hydroxysteroid dehydrogenase (3BHSD) deficiency is a rare genetic disorder of steroid biosynthesis that results in decreased production of all 3 groups of adrenal ...
3-beta (β)-hydroxysteroid dehydrogenase (HSD) deficiency is an inherited disorder that affects hormone-producing glands including the gonads (ovaries in females and testes in males) and the adrenal glands. The gonads ...



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  [★] 脱水素酵素 デヒドロゲナーゼ


  [★] 脱水素酵素 デヒドロゲナーゼ