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1. 止血の概要overview of hemostasis [show details]
… in addition to fibrin, cleaves fibrinogen and a variety of plasma proteins and clotting factors . Plasmin cleaves the polymerized fibrin strand at multiple sites and releases fibrin degradation… site. It is also potentially explosive, and, if unchecked, could lead to thrombosis, vascular inflammation, and tissue damage. This does not usually happen because coagulation is modulated by a number …
2. 創傷の治癒過程の基本原則basic principles of wound healing [show details]
…wounds normally heal in an orderly and efficient manner characterized by overlapping phases of inflammation, epithelialization, fibroplasia, and maturation . Acute wounds transition through the stages … The resulting fibrin matrix stabilizes the wound and provides a provisional scaffold for the wound healing process.…
3. 乳児や小児の播種性血管内凝固disseminated intravascular coagulation in infants and children [show details]
… be higher because of the inflammation from his or her underlying disease. Increased thrombin time – Thrombin time is prolonged when the fibrinogen concentration is low. Fibrin degradation products (FDPs) …
4. 熱、煙または化学的刺激物の吸入傷害inhalation injury from heat smoke or chemical irritants [show details]
…external compression of the upper airway, complicating airway management . In addition to the acute inflammation, damage of ciliary function impairs physiological clearance processes of the airway, leading to … Furthermore, a severe imbalance in alveolar hemostasis and decreased fibrinolytic activity, with massive fibrin deposition in the airways, causes a ventilation-perfusion mismatch . This mismatch is made worse …
5. 外傷患者の凝固障害coagulopathy in trauma patients [show details]
…frequently elevated and fibrinogen levels depleted in acutely injured patients, indicating intravascular fibrin deposition and active fibrinolysis , functional thrombin generation (assayed by the presence of prothrombin … A careful study of markers of coagulopathy and inflammation in 80 trauma patients identified that increasing…