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1. 新生児や乳児の（小）水疱性および膿疱性の病変vesicular pustular and bullous lesions in the newborn and infant [show details]
…upon the clinical features. Microscopic examination of a Wright-stained smear of the contents of a vesicular lesion demonstrates sparse squamous cells and lymphocytes. However, this is usually not necessary …
2. ハンチントン病：遺伝学と病因huntington disease genetics and pathogenesis [show details]
… Reduction in protein degradation, perhaps by blocking or overloading the proteosome degradation system ; the importance of this mechanism… for wild-type huntingtin include roles in the regulation of ciliogenesis, protein trafficking, vesicular transport and anchoring to the cytoskeleton, endocytosis, and postsynaptic signaling . In addition …
3. 肝線維症の病因pathogenesis of hepatic fibrosis [show details]
…activated stellate cells . Fibrosis reflects a balance between matrix production and degradation. The degradation of extracellular matrix is a key event in hepatic fibrosis. Early disruption of the normal …
4. 肝線維症の新しい治療法emerging therapies for hepatic fibrosis [show details]
…promotion of matrix degradation is of special clinical significance given the need to resorb matrix in patients with established fibrosis. Advances in understanding of matrix degradation in liver are likely …
5. 糸球体足細胞のバイオロジーbiology of glomerular podocytes [show details]
…example, podocyte deficiency in the vacuolar protein sorting-34 (Vps34), which controls several vesicular trafficking processes, leads to podocyte vacuolization and defective autophagy, early proteinuria … Another possible mechanism of cytoskeletal rearrangement is via the degradation of dynamin,…