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1. 成人の多発性硬化症の評価と診断evaluation and diagnosis of multiple sclerosis in adults [show details]
… Multiple sclerosis (MS) is the most common immune-mediated inflammatory demyelinating disease of the central nervous system.… the McDonald criteria are not intended for distinguishing MS from other neurologic conditions. The core requirement of the diagnosis of MS is the objective demonstration of dissemination of central nervous…
2. 多発性内分泌腫瘍2型の分類および遺伝学classification and genetics of multiple endocrine neoplasia type 2 [show details]
… Multiple endocrine neoplasia type 2 (MEN2) is an autosomal dominant disorder with an estimated prevalence of 1 per 30,000… recognition pocket in the tyrosine kinase catalytic core of the RET protein.…
3. 多発性骨髄腫：臨床的特徴、検査所見、診断multiple myeloma clinical features laboratory manifestations and diagnosis [show details]
…from a core biopsy specimen, when possible. However, if the percent plasma cells in the aspirate and core biopsy differ, the higher value should be used. Hematoxylin and eosin stain of the core biopsy… Multiple myeloma (MM) is characterized by the neoplastic proliferation of plasma cells producing a monoclonal immunoglobulin.…
4. 良性乳房疾患の概要overview of benign breast disease [show details]
…carcinoma in situ (DCIS). Papillomas can occur as solitary or multiple lesions. Classically, the standard approach to a papilloma diagnosed by core needle biopsy (CNB) has been to perform a surgical excision …
5. 小児の双極性障害：補助的精神療法の有効性と中心的要素pediatric bipolar disorder efficacy and core elements of adjunctive psychotherapy [show details]
… efficacious and is a core element of more elaborate and intensive psychotherapies (eg, family therapy). This topic reviews the efficacy and core elements of different adjunctive… Evidence supporting the psychoeducation for pediatric bipolar disorder includes multiple randomized trials : One trial compared psychoeducation…