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1. 遺伝学の基礎概念：染色体と細胞分化basic genetics concepts chromosomes and cell division [show details]
… diploidy. These cells are large platelet-producing cells in the bone marrow; typically they have a ploidy of 32n or 64n, due to multiple rounds of DNA replication without cell division. Certain pathologic …
2. 幹細胞の概要overview of stem cells [show details]
… These cells are therefore called induced pluripotent stem (iPS) cells. The ability to induce pluripotency has changed the landscape of stem cell biology along several lines.… after loss of some cells in other tissues. The implications of this are that mature cells are thought to only have a limited number of cell divisions, as opposed to stem cells.…
3. マントル細胞リンパ腫の病理学pathobiology of mantle cell lymphoma [show details]
…pre-germinal center B cells of the mantle zone, while a subset of MCL may originate from marginal zone or peripheral blood memory B cells. All cases of MCL demonstrate increased cell division and replication… NF-kB inhibitor results in cell cycle arrest and apoptosis . More recent work using pharmacological profiling identified a subset of MCL cell lines that are insensitive to BCR inhibitors,… can induce apoptotic cell death. As mentioned earlier, a minority of patients with MCL will demonstrate mutations or deletions involving the TP53 gene. The diagnostic category of "mantle cell lymphoma"…
4. 造血細胞移植後の移植片対腫瘍効果の生物学biology of the graft versus tumor effect following hematopoietic cell transplantation [show details]
… Several cell lines with cytotoxic activity have been developed which have phenotypic and biological characteristics very similar to NK cells and NK-like T cells. The cell line TALL-104 originated… site of target cell adhesion. Perforin induces pore formation in the membrane of the target cell, causing osmotic lysis and introducing granzymes and granulysin, which induce apoptosis .…
5. 頭頸部の扁平上皮癌化：分子学的および遺伝学的変化head and neck squamous cell carcinogenesis molecular and genetic alterations [show details]
… antigen-induced activation and overexpression of co-inhibitory receptors/ligands on the tumor cell surface/lymphocytes, such as programmed cell death protein 1 (PD-1) and programmed cell death ligand… complete inactivation of p53 in HPV associated HNSCC cell lines was associated with resistance to radiation therapy and aggressive tumor behavior .… CDK4 and CDK6 to promote cell cycle progression in the G1-S transition, which is critical to commitment to replication and division .…

Japanese Journal

諸種光源ニ於ケル細胞分裂誘起線ノ吟味

荒井博
京都府立医科大学雑誌 34(1/2/3/4), 1100-1102, 1942
Mittels Saecharomyces ellipsoideus als Detektor wurden die mitogenetischen Strahlen in dem Licht der Kohlen-Bogenlampe entdeckt, doch liessen sich ebensolche Strahlen weder in dem Licht der Eisen-Boge …
NAID 110007120319

1. Vitamin Cト細胞分裂誘起線 2. 腦下垂體前葉及ビ脾臟浸出液ノ酵母菌増殖ニ及ボス影響3. 2, 6 Dichlorphenolindophenolノ筋肉ニ對スル作用

河村謙一
岡山醫學會雜誌 50(1), 147-153, 1938
The results of the author's experiments are roughly as follows:<BR>1. When tested according to the yeast method, it is doubtful whether vitamin C generates "Mitogenetische Strahlen" wh …
NAID 130006169996

螢ノ發光ニ關スル研究(第3報) : 其3 螢ニ於ケル細胞分裂誘起線(Mitogenetische Strahlen)ニ就テ

岡田徳一,荒井博
京都府立医科大学雑誌 21(1/2/3/4), 643-656, 1937
Wir untersuchten den mitogenetischen Effekt des Leuchtkaferlichts durch die Hefe-Methode und gelangten zu folgenden Resultaten: 1) Ein lebender Leuchtkafer sowie das Leuchtorgan allein zeigen den mito …
NAID 110007119464