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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/02/13 00:17:24」(JST)

Trepibutone is a drug used for functional gastrointestinal disorders.

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English Journal

pH-independent controlled-release microspheres using polyglycerol esters of fatty acids.

Akiyama Y, Yoshioka M, Horibe H, Hirai S, Kitamori N, Toguchi H.SourceDDS Research Laboratories, Takeda Chemical Industries, Ltd., Osaka, Japan.
Journal of pharmaceutical sciences.J Pharm Sci.1994 Nov;83(11):1600-7.
The release of a drug having low solubility in a certain pH range from controlled-release microspheres using tetraglycerol pentastearate and tetraglycerol monostearate in combination as the matrix base showed pH dependence. Trepibutone, an acidic drug having lower solubility in an acidic medium, was
PMID 7891282

ROLE OF AN INTRACELLULAR Ca STORE IN TREPIBUTONE (AA-149)-INDUCED RELAXATION OF THE DEPOLARIZED SMOOTH MUSCLE OF THE GUINEA-PIG TAENIA COLI

SATOH Hiroshi,INADA Ikuko,MAKI Yoshitaka
The Japanese Journal of Pharmacology 31(4), 593-599, 1981
… Trepibutone, a newly synthesized smooth muscle relaxant, given before CaCl2 … The CCh contraction was enhanced after inhibition of the Ca contracture by trepibutone. … The inhibitory effect of trepibutone on the Ca contracture was markedly reduced in the presence of CCh, whereas that of D-600 was not affected. …
NAID 130000835649

RELAXING ACTION OF TREPIBUTONE (AA-149) ON THE ISOLATED SPHINCTER OF ODDI AND SMALL INTESTINE OF RABBITS

SATOH Hiroshi,INADA Ikuko,MAKI Yoshitaka
The Japanese Journal of Pharmacology 31(4), 587-592, 1981
… We investigated the smooth muscle relaxing action of trepibutone [3-(2, 4, 5-triethoxybenzoyl)pro pi onic acid: AA-149] using assays of the isolated preparations of sphincter of Oddi, duodenum, jejunum and ileum of rabbits. … Trepibutone (10-6-10-3 … The actions of trepibutone were not altered by pretreatment with tetrodotoxin, phentolamine or propranolol. …
NAID 130000835648

リンク元

Trepibutone
Systematic (IUPAC) name
	4-Oxo-4-(2,4,5-triethoxyphenyl)butanoic acid
Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy cat.	?
Legal status	?
Identifiers
CAS number	41826-92-0
ATC code	A03AX09
PubChem	CID 5536
ChemSpider	5335
UNII	H1187LU49Q
Chemical data
Formula	C16H22O6
Mol. mass	310.34 g/mol