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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/01/20 00:45:06」(JST)

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Ticlopidine (trade name Ticlid) is an antiplatelet drug in the thienopyridine family. Like clopidogrel, it is an adenosine diphosphate (ADP) receptor inhibitor. It is used in patients in whom aspirin is not tolerated, or in whom dual antiplatelet therapy is desirable. Because it has been reported to increase the risk of thrombotic thrombocytopenic purpura (TTP) and neutropenia, its use has largely been supplanted by the newer drug, clopidogrel, which is felt to have a much lower hematologic risk. Its niche role as an alternative in those patients who do not tolerate Clopidogrel has now been superdeded by Ticagrelor and Prasugrel. The usual dose is 250 mg twice daily by the oral route.

Action[edit]

Inhibits platelet aggregation by altering the function of platelet membranes by blocking ADP receptors. This prevents the conformational change of glycoprotein IIb/IIIa which allows platelet binding to fibrinogen.
Prolongs bleeding time.
Decreased incidence of stroke in high-risk patients.

Contraindications[edit]

Hypersensitivity
Bleeding disorders
Active bleeding
Severe liver disease

Precautions[edit]

Risk of bleeding (trauma, surgery, history of peptic ulcer disease)
Renal or hepatic impairment
Geriatric patients (increased sensitivity)
Pregnancy, lactation, or children under 18
Neutropenia
Thrombotic thrombocytopenic purpura

UpToDate Contents

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1. 脳卒中の二次予防のための抗血小板療法 antiplatelet therapy for secondary prevention of stroke
2. 非ST上昇型急性冠症候群における抗血小板薬 antiplatelet agents in acute non st elevation acute coronary syndromes
3. Drug-induced thrombotic microangiopathy
4. 薬剤誘発性の好中球減少および無顆粒球症 drug induced neutropenia and agranulocytosis
5. 待機的経皮的冠動脈インターベンションのための抗血栓療法：臨床研究 antithrombotic therapy for elective percutaneous coronary intervention clinical studies

English Journal

Effects of various factors of ultrasonic treatment on the extraction recovery of drugs from fish tissues.

Magiera S1, Pardylla A2, Baranowska I2.
Ultrasonics sonochemistry.Ultrason Sonochem.2015 Sep;26:388-98. doi: 10.1016/j.ultsonch.2015.03.005. Epub 2015 Mar 12.
In the present research, a combined extraction method of ultrasound-assisted extraction (UAE) in conjunction with solid phase extraction (SPE) was applied to isolation and enrichment of selected drugs (metoprolol, ticlopidine, propranolol, carbamazepine, naproxen, acenocumarol, diclofenac, ibuprofen
PMID 25794999

P2Y12 receptor inhibitors for secondary prevention of ischemic stroke.

Liu F1, Tantry US, Gurbel PA.
Expert opinion on pharmacotherapy.Expert Opin Pharmacother.2015 Jun;16(8):1149-65. doi: 10.1517/14656566.2015.1035256. Epub 2015 Apr 14.
INTRODUCTION: Ischemic stroke (IS) is a major cause of death and disability worldwide. The P2Y12 receptor plays a critical role in the formation of a stable thrombus leading to ischemic complications. Therefore, P2Y12 receptor inhibitors constitute a major antiplatelet strategy in the secondary prev
PMID 25873127

Balancing the risks and benefits of dual platelet inhibition.

Keaney JF Jr1.
The New England journal of medicine.N Engl J Med.2015 May 7;372(19):1854-6. doi: 10.1056/NEJMe1502137. Epub 2015 Mar 14.
PMID 25773507

Japanese Journal

周術期の抗血栓療法をヘパリンに置換した手術症例の検討

松岡崇志,井上幸治,水野桂 [他]
泌尿器科紀要 58(5), 223-226, 2012-05
… In transurethral surgery, patients taking warfarin and antiplatelet drugs (aspirin or ticlopidine) had a statistically significant increase in bleeding complications compared to patients taking warfarin alone. …
NAID 40019283461

症例報告硬膜外ブロック後に生じた腰椎硬膜外血腫の1例

田中智史,松原祐二,深谷直樹 [他]
臨床整形外科 47(2), 191-195, 2012-02
NAID 40019203693

Related Pictures

★リンクテーブル★

リンク元	「チクロピジン」
拡張検索	「ticlopidine hydrochloride」

「チクロピジン」

Ticlopidine
Systematic (IUPAC) name
	5-(2-chlorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine
Clinical data
Trade names	Ticlid
AHFS/Drugs.com	monograph
MedlinePlus	a695036
Pregnancy cat.	B1 (AU) C (US)
Legal status	?
Routes	Oral
Pharmacokinetic data
Bioavailability	>80%
Protein binding	98%
Metabolism	Hepatic
Half-life	*12 hours (single dose)
Excretion	Renal and fecal
Identifiers
CAS number	55142-85-3
ATC code	B01AC05
PubChem	CID 5472
DrugBank	DB00208
ChemSpider	5273
UNII	OM90ZUW7M1
KEGG	D08594
ChEBI	CHEBI:9588
ChEMBL	CHEMBL833
Chemical data
Formula	C14H14ClNS
Mol. mass	263.786 g/mol
	SMILES Clc1ccccc1CN3Cc2c(scc2)CC3;
	InChI InChI=1S/C14H14ClNS/c15-13-4-2-1-3-11(13)9-16-7-5-14-12(10-16)6-8-17-14/h1-4,6,8H,5,7,9-10H2 ; Key:PHWBOXQYWZNQIN-UHFFFAOYSA-N ;
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