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a sulfa drug used like sulfadiazine and also in veterinary medicine (同)sulfamezathine

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/08/07 18:35:24」(JST)

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Sulfadimidine or sulfamethazine is a sulfonamide antibacterial.

There are non-standardized^a abbreviations for it as "sulfadimidine" (abbreviated SDI^[1]^[2] and more commonly but less reliably^b SDD^[3]^[4]) and as "sulfamethazine" (abbreviated SMT^[5]^[6] and more commonly but less reliably^c SMZ^[7]^[8]). Other names include sulfadimerazine, sulfadimezine, and sulphadimethylpyrimidine.

Notes

^a Abbreviations are not found in the databases (such as ChemDB, ChemIDplus, PubChem), but often seen in the published literature.^{[citation needed]}
^b "SDD" is not found in databases, but often seen in the published literature; it could however be confused with Tiferron/Sodium catechol sulfate (1,2-Dihydroxybenzene-3,5-disulfonic acid disodium Salt), uncommon but found officially abbreviated SDD in the ChemIDplus database.^[9]
^c "SMZ" is not found in databases, but often seen in the published literature; it could however be confused with sulfamethoxazole, also seen abbreviated SMZ.^{[citation needed]}

References

^ Romváry, A; Simon, F (1992). "Sulfonamide residues in eggs". Acta veterinaria Hungarica 40 (1–2): 99–106. ISSN 0236-6290. PMID 1476095.
^ Reddy; Jain, S. K.; Uppal, R. P. (1988). "Pharmacokinetic studies of sulphonamides in poultry". Indian Journal of Animal Sciences.
^ Kamakura, K; Hasegawa, M; Koiguchi, S; Miyata, M; Okamoto, K; Narita, M; Hirahara, Y; Yamana, T et al. (1993). "Studies on the identification of sulfadimidine in pork by high performance liquid chromatography with photodiode array detector and gas chromatograph-mass spectrometry". Eisei Shikenjo hokoku. Bulletin of National Institute of Hygienic Sciences (111): 61–5. ISSN 0077-4715. PMID 7920569.
^ Garg, SK; Ghosh, SS; Mathur, VS (Jan 1986). "Comparative pharmacokinetic study of four different sulfonamides in combination with trimethoprim in human volunteers". International journal of clinical pharmacology, therapy, and toxicology 24 (1): 23–5. ISSN 0174-4879. PMID 3485584.
^ Peña, MS; Salinas, F; Mahedero, MC; Aaron, JJ (Feb 1994). "Solvent effect on the determination of sulfamethazine by room-temperature photochemically induced fluorescence". Talanta 41 (2): 233–6. doi:10.1016/0039-9140(94)80113-4. ISSN 0039-9140. PMID 18965913.
^ Kaniou, S; Pitarakis, K; Barlagianni, I; Poulios, I (Jul 2005). "Photocatalytic oxidation of sulfamethazine". Chemosphere 60 (3): 372–80. doi:10.1016/j.chemosphere.2004.11.069. ISSN 0045-6535. PMID 15924956.
^ Calvo, R; Sarabia, S; Carlos, R; Du Souich, P (Mar 1987). "Sulfamethazine absorption and disposition: effect of surgical procedures for gastroduodenal ulcers". Biopharmaceutics & drug disposition 8 (2): 115–24. doi:10.1002/bdd.2510080203. ISSN 0142-2782. PMID 3593892.
^ De Liguoro, M; Fioretto, B; Poltronieri, C; Gallina, G (Jun 2009). "The toxicity of sulfamethazine to Daphnia magna and its additivity to other veterinary sulfonamides and trimethoprim". Chemosphere 75 (11): 1519–24. doi:10.1016/j.chemosphere.2009.02.002. ISSN 0045-6535. PMID 19269673.
^ http://chem.sis.nlm.nih.gov/chemidplus/ProxyServlet?objectHandle=Search&actionHandle=getAll3DMViewFiles&nextPage=jsp%2Fcommon%2FChemFull.jsp%3FcalledFrom%3Dlite&chemid=000149451&formatType=_3D^{[dead link]}

English Journal

Spectral, thermal, and molecular modeling studies on the encapsulation of selected sulfonamide drugs in β-cyclodextrin nano-cavity.

Bani-Yaseen AD1, Mo'ala A2.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.Spectrochim Acta A Mol Biomol Spectrosc.2014 Oct 15;131:424-31. doi: 10.1016/j.saa.2014.04.136. Epub 2014 Apr 30.
In the present work the inclusion complexation of three sulfonamide (SA) drugs, namely sulfisoxazole (SSX), sulfamethizole (SMZ), and Sulfamethazine (STM) with β-cyclodextrin (β-CD) has been investigated using UV-Vis spectroscopy, DSC, (1)H NMR spectroscopy, and molecular modeling methods. The bin
PMID 24835946

Invasive plant-derived biochar inhibits sulfamethazine uptake by lettuce in soil.

Rajapaksha AU1, Vithanage M2, Lim JE3, Ahmed MB4, Zhang M5, Lee SS3, Ok YS6.
Chemosphere.Chemosphere.2014 Sep;111:500-4. doi: 10.1016/j.chemosphere.2014.04.040. Epub 2014 May 22.
Veterinary antibiotics are frequently detected in soils posing potential contamination of food crops. Sulfamethazine (SMT) uptake was investigated by lettuce (Lactuca sativa L.) grown in the soils treated with/without biochar derived from an invasive plant, burcucumber (Sicyos angulatus L.) (BBC700)
PMID 24997958

Miniaturized graphene-based pipette tip extraction coupled with liquid chromatography for the determination of sulfonamide residues in bovine milk.

Yan H1, Sun N2, Liu S2, Row KH3, Song Y2.
Food chemistry.Food Chem.2014 Sep 1;158:239-44. doi: 10.1016/j.foodchem.2014.02.089. Epub 2014 Feb 28.
A miniaturized graphene-based pipette tip extraction (M-G-PTE) method coupled with liquid chromatography-ultraviolet detection was developed for rapid screening of sulfadimidine, sulfachloropyridazine, sulfamonomethoxine, and sulfachloropyrazine residues in bovine milk. Because of the large surface
PMID 24731337

Japanese Journal

大阪府下で1995年から2003年に採取した畜水産食品中の残留合成抗菌剤

吉田精作,田口修三,田中之雄
日本食品化学学会誌 12(1), 46-50, 2005-04-29
… Sulfadimidine was detected in one (2.1 mg/kg) of 110 samples of domestic pork. …
NAID 110007367312

大阪府下で1990年から1994年に採取した畜水産食品中の残留抗菌性物質

吉田精作,田口修三,住本建夫,福島成彦
衛生化学 42(2), 189-192, 1996-04-30
… Sulfadimidine was detected in one (0.04 mg/kg) of 44 samples of imported pork. …
NAID 110003642211

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★リンクテーブル★

リンク元	「スルファジミジン」「スルファメタジン」「sulfamethazine」

「スルファジミジン」

Sulfamethazine
Systematic (IUPAC) name
	4-amino-N-(4,6-dimethylpyrimidin-2-yl); benzenesulfonamide
Clinical data
AHFS/Drugs.com	International Drug Names
Legal status	?
Identifiers
CAS number	57-68-1
ATC code	J01EB03 QJ01EQ03 QP51AG01
PubChem	CID 5327
DrugBank	DB01582
ChemSpider	5136
UNII	48U51W007F
KEGG	D02436
ChEBI	CHEBI:102265
ChEMBL	CHEMBL446
NIAID ChemDB	027749
Chemical data
Formula	C12H14N4O2S
Mol. mass	278.33 g/mol
	SMILES O=S(=O)(Nc1nc(cc(n1)C)C)c2ccc(N)cc2;
	InChI InChI=1S/C12H14N4O2S/c1-8-7-9(2)15-12(14-8)16-19(17,18)11-5-3-10(13)4-6-11/h3-7H,13H2,1-2H3,(H,14,15,16) ; Key:ASWVTGNCAZCNNR-UHFFFAOYSA-N ;
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　　[★]

英: sulfadimidine
関: 抗菌薬、スルファメチアジン、スルファメタジン

短時間作用性サルファ剤

「スルファメタジン」

　　[★]

英: sulfamethazine
同: スルファジミジン sulfadimidine
関: 抗菌薬

サルファ剤

「sulfamethazine」

　　[★]

スルファメチアジン

関: sulfadimidine

[1] Romváry, A; Simon, F (1992). "Sulfonamide residues in eggs". Acta veterinaria Hungarica 40 (1–2): 99–106. ISSN 0236-6290. PMID 1476095.

[2] Reddy; Jain, S. K.; Uppal, R. P. (1988). "Pharmacokinetic studies of sulphonamides in poultry". Indian Journal of Animal Sciences.

[3] Kamakura, K; Hasegawa, M; Koiguchi, S; Miyata, M; Okamoto, K; Narita, M; Hirahara, Y; Yamana, T et al. (1993). "Studies on the identification of sulfadimidine in pork by high performance liquid chromatography with photodiode array detector and gas chromatograph-mass spectrometry". Eisei Shikenjo hokoku. Bulletin of National Institute of Hygienic Sciences (111): 61–5. ISSN 0077-4715. PMID 7920569.

[4] Garg, SK; Ghosh, SS; Mathur, VS (Jan 1986). "Comparative pharmacokinetic study of four different sulfonamides in combination with trimethoprim in human volunteers". International journal of clinical pharmacology, therapy, and toxicology 24 (1): 23–5. ISSN 0174-4879. PMID 3485584.

[5] Peña, MS; Salinas, F; Mahedero, MC; Aaron, JJ (Feb 1994). "Solvent effect on the determination of sulfamethazine by room-temperature photochemically induced fluorescence". Talanta 41 (2): 233–6. doi:10.1016/0039-9140(94)80113-4. ISSN 0039-9140. PMID 18965913.

[6] Kaniou, S; Pitarakis, K; Barlagianni, I; Poulios, I (Jul 2005). "Photocatalytic oxidation of sulfamethazine". Chemosphere 60 (3): 372–80. doi:10.1016/j.chemosphere.2004.11.069. ISSN 0045-6535. PMID 15924956.

[7] Calvo, R; Sarabia, S; Carlos, R; Du Souich, P (Mar 1987). "Sulfamethazine absorption and disposition: effect of surgical procedures for gastroduodenal ulcers". Biopharmaceutics & drug disposition 8 (2): 115–24. doi:10.1002/bdd.2510080203. ISSN 0142-2782. PMID 3593892.

[8] De Liguoro, M; Fioretto, B; Poltronieri, C; Gallina, G (Jun 2009). "The toxicity of sulfamethazine to Daphnia magna and its additivity to other veterinary sulfonamides and trimethoprim". Chemosphere 75 (11): 1519–24. doi:10.1016/j.chemosphere.2009.02.002. ISSN 0045-6535. PMID 19269673.

[9] ttp://chem.sis.nlm.nih.gov/chemidplus/ProxyServlet?objectHandle=Search&actionHandle=getAll3DMViewFiles&nextPage=jsp%2Fcommon%2FChemFull.jsp%3FcalledFrom%3Dlite&chemid=000149451&formatType=_3D^{[dead link]}

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sulfadimidine