The first report of direct inhibitors that target the C-terminal MEEVD region on heat shock protein 90.
Buckton LK1, Wahyudi H, McAlpine SR.
Chemical communications (Cambridge, England).Chem Commun (Camb).2016 Jan 11;52(3):501-4. doi: 10.1039/c5cc03245h. Epub 2015 Nov 3.
Sixteen linear and cyclic peptides were designed de novo to target the C-terminus of heat shock protein 90 (Hsp90). Protein binding data indicates that three compounds directly block co-chaperone access to Hsp90's C-terminus and luciferase renaturation assays confirm Hsp90-mediated protein folding i
Nano-cage-mediated refolding of insulin by PEG-PE micelle.
Fang X1, Yang T2, Wang L2, Yu J3, Wei X3, Zhou Y3, Wang C4, Liang W5.
Biomaterials.Biomaterials.2016 Jan;77:139-48. doi: 10.1016/j.biomaterials.2015.11.007. Epub 2015 Nov 10.
Insulin aggregation has pronounced pharmaceutical implications and biological importance. Deposition of insulin aggregates is associated with type II diabetes and instability of pharmaceutical formulations. We present in this study the renaturation effect of PEG-PE micelle on dithiothreitol (DTT)-de
Molecular characterization of a cathepsin F-like protease in Trichinella spiralis.
Qu ZG1, Ma XT2, Li WH3, Zhang NZ4, Yue L5, Cui JM6, Cai JP7,8, Jia WZ9,10, Fu BQ11,12.
Parasites & vectors.Parasit Vectors.2015 Dec 21;8(1):652. doi: 10.1186/s13071-015-1270-y.
BACKGROUND: Trichinellosis is a re-emerging infectious disease, caused by Trichinella spp. Cathepsin F belongs to cysteine protease that is a major virulence factor for parasitic helminths, and it may be a potential anti-helminth drug target and vaccine candidate. The aim of this study was to clone,
Thermal Denaturation and Renaturation of γ-Glutamyltranspeptidase of Escherichia coli
HO Thao Van,KAMEI Kaeko,WADA Kei [他]
Bioscience, Biotechnology, and Biochemistry 77(2), 409-412, 2013-02
re·na·tur·a·tion (rē-nā′chər-ā′shən) n. The process by which proteins or complementary strands of nucleic acids re-form their native conformations. [From renature, to undergo renaturation: re-+ (de)nature.] re·na′ture v. renaturation (ˌriːneɪtʃəˈreɪʃən
Home » Renaturation Definition noun, plural: renaturations (molecular biology) The conversion of denatured protein or nucleic acid to its native configuration Supplement Renaturation in molecular biology refers to the reconstruction of a protein ...