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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/03/21 00:01:31」(JST)

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Ramosetron (INN) is a serotonin 5-HT₃ receptor antagonist for the treatment of nausea and vomiting.^[1] Ramosetron is also indicated for a treatment of “diarrhea-predominant irritable bowel syndrome in males”.^[2] In India it is marketed under the brand name of "IBset".

It is only licensed for use in Japan and selected Southeast Asian countries.　In Japan it is sold under the tradename Iribo (イリボー). ^[3] Elsewhere it is commonly sold under the tradename Nasea and in India as Nozia (300 mcg/ml Inj. & 100 mcg Tab.) ^[4]

References

^ Fujii Y, Saitoh Y, Tanaka H, Toyooka H (February 2000). "Ramosetron for preventing postoperative nausea and vomiting in women undergoing gynecological surgery". Anesth. Analg. 90 (2): 472–5. doi:10.1097/00000539-200002000-00043. PMID 10648342.
^ http://www.astellas.com/en/corporate/news/detail/astellas-launches-irribow-for.html
^ Summary in Japanese. Retrieved on September 4, 2012.
^ Abridged prescribing information - Nasea (MIMS Philippines). Retrieved on June 13, 2008.

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UpToDate Contents

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1. 麻酔後ケア病棟における合併症発生の概要 overview of complications occurring in the post anesthesia care unit
2. 化学療法誘発性悪心および嘔吐の予防および治療 prevention and treatment of chemotherapy induced nausea and vomiting
3. Tonsillectomy and/or adenoidectomy in children: Preoperative evaluation and care

English Journal

A Comparative Efficacy of Propacetamol and Ketorolac in Postoperative Patient Controlled Analgesia.

Heo BH1, Park JH1, Choi JI1, Kim WM1, Lee HG1, Cho SY1, Yoon MH1.
The Korean journal of pain.Korean J Pain.2015 Jul;28(3):203-9. doi: 10.3344/kjp.2015.28.3.203. Epub 2015 Jul 1.
BACKGROUND: Ketorolac has been used as a postoperative analgesia in combination with opioids. However, the use of ketorolac may produce serious side effects in vulnerable patients. Propacetamol is known to induce fewer side effects than ketorolac because it mainly affects the central nervous system.
PMID 26175881

Inhibitory effects of SKI3246, the rhizome extract of Atractylodes japonica, on visceral hypersensitivity in experimental irritable bowel syndrome rat models.

Son HJ1, Jung K, Park YH, Jeon HJ, Kang M, Ryu KH, Pyo SS, Eutamene H, Bueno L, Sun WS.
Archives of pharmacal research.Arch Pharm Res.2015 May;38(5):642-9. doi: 10.1007/s12272-014-0454-x. Epub 2014 Jul 30.
We evaluated the effect of SKI3246, the 50% ethanol extract of the rhizome of Atractylodes japonica, on visceral hypersensitivity, which is a major characteristic feature of IBS. We used various rat models of visceral hypersensitivity to assess the visceral pain responses to colorectal distension (C
PMID 25070763

Effect of ramosetron on the QT interval during sevoflurane anaesthesia in children: a prospective observational study.

Lee JH1, Yoo EK, Song IK, Kim JT, Kim HS.
European journal of anaesthesiology.Eur J Anaesthesiol.2015 May;32(5):330-5. doi: 10.1097/EJA.0000000000000200.
BACKGROUND: We investigated the effects of concomitant administration of sevoflurane and ramosetron on the QT interval, the interval between the peak and end of the T wave (Tpe) and Tpe/QT ratio in children.OBJECTIVES: To compare the effects of concomitant administration of ramosetron and sevofluran
PMID 25485883

Japanese Journal

下痢型過敏性腸症候群に対するラモセトロン塩酸塩の効果 (特集過敏性腸症候群の病態と診療)

千葉俊美,鳥谷洋右,久多良徳彦 [他]
消化器内科 59(3), 226-230, 2014-09
NAID 40020212623

下痢型過敏性腸症候群(IBS-D)におけるS100蛋白発現および遺伝子多型の検討 (特集過敏性腸症候群の病態と診療)

塩谷昭子,楠裕明,眞部紀明 [他]
消化器内科 59(3), 207-212, 2014-09
NAID 40020212580

輸液フィルター通過性試験における小児投与量1点での吸光度測定法の有用性

山之内恒昭,堀内賢一,石井一成 [他],三村泰彦,加藤敦,足立伊佐雄
薬学雑誌. 乙号 134(5), 671-677, 2014
… The adsorption of Bevacizumab, Trastuzumab, Rituximab, Nedaplatin, Vincristine sulfate, Nogitecan hydrochloride, Actinomycin D and Ramosetron hydrochloride to 0.2 μm endotoxin-retentive in-line filters was evaluated with pediatric doses by UV spectrophotometry. … The results indicated that some drug adsorption was shown with Nogitecan hydrochloride, Actinomycin D and Ramosetron hydrochloride, and good recovery was shown with the other five drugs. …
NAID 130004756425

「ラモセトロン」

Ramosetron
Systematic (IUPAC) name
	(1-methyl-1H-indol-3-yl)[(5R)-4,5,6,7-tetrahydro-1H-benzimidazol-5-yl]methanone
Clinical data
AHFS/Drugs.com	International Drug Names
Routes of; administration	Intravenous
Pharmacokinetic data
Biological half-life	5.8 hours
Identifiers
CAS Number	132907-72-3
ATC code	none
PubChem	CID 108000
IUPHAR/BPS	2301; [3H]ramosetron: 2305
ChemSpider	97112
UNII	7ZRO0SC54Y
ChEMBL	CHEMBL1643895
Chemical data
Formula	C17H17N3O
Molar mass	279.33 g/mol
	SMILES CN1C=C(C2=CC=CC=C21)C(=O)[C@@H]3CCC4=C(C3)NC=N4 ;
	InChI InChI=1S/C17H17N3O/c1-20-9-13(12-4-2-3-5-16(12)20)17(21)11-6-7-14-15(8-11)19-10-18-14/h2-5,9-11H,6-8H2,1H3,(H,18,19)/t11-/m1/s1 ; Key:NTHPAPBPFQJABD-LLVKDONJSA-N ;
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