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- pemirolast potassium
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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/02/03 23:43:53」(JST)
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Pemirolast
|
| Clinical data |
| Trade names |
Alamast |
| AHFS/Drugs.com |
Monograph |
Pregnancy
category |
- US: C (Risk not ruled out)
|
Routes of
administration |
Oral, ophthalmic |
| ATC code |
none |
| Legal status |
| Legal status |
|
| Identifiers |
IUPAC name
- 9-methyl-3-(1H-tetrazol-5-yl)-4H-pyrido[1,2-a]pyrimidin-4-one
|
| CAS Number |
69372-19-6 Y |
| PubChem (CID) |
57697 |
| IUPHAR/BPS |
7329 |
| DrugBank |
DB00885 N |
| ChemSpider |
51990 N |
| UNII |
2C09NV773M N |
| KEGG |
D07476 Y |
| ChEMBL |
CHEMBL1201198 N |
| ECHA InfoCard |
100.222.995 |
| Chemical and physical data |
| Formula |
C10H8N6O |
| Molar mass |
228.21 g/mol |
| 3D model (Jmol) |
Interactive image |
SMILES
-
CC1=CC=CN2C1=NC=C(C2=O)C3=NNN=N3
|
| NY (what is this?) (verify) |
Pemirolast (INN) is a mast cell stabilizer used as an anti-allergic drug therapy. It is marketed under the tradenames Alegysal and Alamast.
It has also been studied for the treatment of asthma.
References
- Tinkelman DG, Berkowitz RB (February 1991). "A pilot study of pemirolast in patients with seasonal allergic rhinitis". Ann Allergy. 66 (2): 162–5. PMID 1994787.
- Kawashima T, Iwamoto I, Nakagawa N, Tomioka H, Yoshida S (1994). "Inhibitory effect of pemirolast, a novel antiallergic drug, on leukotriene C4 and granule protein release from human eosinophils". Int. Arch. Allergy Immunol. 103 (4): 405–9. doi:10.1159/000236662. PMID 8130655.
- Abelson MB, Berdy GJ, Mundorf T, Amdahl LD, Graves AL (October 2002). "Pemirolast potassium 0.1% ophthalmic solution is an effective treatment for allergic conjunctivitis: a pooled analysis of two prospective, randomized, double-masked, placebo-controlled, phase III studies". J Ocul Pharmacol Ther. 18 (5): 475–88. doi:10.1089/10807680260362759. PMID 12419098.
- Kemp JP, Bernstein IL, Bierman CW, et al. (June 1992). "Pemirolast, a new oral nonbronchodilator drug for chronic asthma". Ann Allergy. 68 (6): 488–91. PMID 1610024.
External links
- Mitsubishi Tanabe Pharma Corporation (2007). "ALEGYSAL (English)" (PDF). Retrieved 2008-09-02.
- "DailyMed Announcements". U.S. National Library of Medicine. 2005. Retrieved 2008-09-02.
|
Antihistamines (R06)
|
|
| Aminoalkyl ethers |
- Bromazine (bromodiphenhydramine)
- Carbinoxamine
- Clemastine
- Chlorphenoxamine
- Diphenylpyraline
- Diphenhydramine
- Doxylamine
- Orphenadrine
- Phenyltoloxamine
|
|
| Substituted alkylamines |
- Brompheniramine
- Chlorphenamine
- Dexbrompheniramine (+pseudoephedrine)
- Dexchlorpheniramine (+betamethasone)
- Dimetindene
- Pheniramine
- Talastine
|
|
| Substituted ethylenediamines |
- Chloropyramine
- Histapyrrodine
- Mepyramine
- Methapyrilene
- Tripelennamine (pyribenzamine)
|
|
| Phenothiazine derivatives |
- Alimemazine
- Fenethazine
- Hydroxyethylpromethazine
- Isothipendyl
- Mequitazine
- Methdilazine
- Oxomemazine
- Promethazine
|
|
| Piperazine derivatives |
- Buclizine
- Cetirizine
- Chlorcyclizine
- Cinnarizine
- Cyclizine
- Hydroxyzine
- Meclizine
- Oxatomide
|
|
| Others for systemic use |
- Antazoline
- Azanator
- Azatadine
- Bamipine
- Cyproheptadine
- Deptropine
- Ebastine
- Emedastine
- Epinastine
- Ketotifen
- Latrepirdine
- Mebhydrolin
- Mizolastine
- Olopatadine
- Phenindamine
- Pimethixene
- Pyrrobutamine
- Quifenadine
- Rupatadine
- Triprolidine
- selective (Acrivastine
- Astemizole
- Azelastine
- Bilastine
- Desloratadine
- Fexofenadine
- Loratadine
- Terfenadine)
|
|
| For topical use |
- Bamipine
- Chloropyramine
- Chlorphenoxamine
- Clemastine
- Dimetindene
- Diphenhydramine
- Isothipendyl
- Mepyramine
- Promethazine
- Thenalidine
|
UpToDate Contents
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English Journal
- Inhibition and stimulation of activity of purified recombinant CYP11A1 by therapeutic agents.
- Mast N, Linger M, Pikuleva IA.SourceDepartment of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, OH 44106, USA.
- Molecular and cellular endocrinology.Mol Cell Endocrinol.2012 Oct 23. pii: S0303-7207(12)00465-0. doi: 10.1016/j.mce.2012.10.013. [Epub ahead of print]
- In vertebrates, the biosynthesis of steroid hormones is initiated by cytochrome P450 CYP11A1 which converts cholesterol to pregnenolone. We investigated whether some of the experimental and FDA-approved therapeutic agents alter the activity of CYP11A1 in the reconstituted system in vitro. We found t
- PMID 23089212
- Pemirolast reduces cisplatin-induced kaolin intake in rats.
- Tatsushima Y, Egashira N, Matsushita N, Kurobe K, Kawashiri T, Yano T, Oishi R.SourceDepartment of Pharmacy, Kyushu University Hospital, Fukuoka, Japan. youko820@pharmst.med.kyushu-u.ac.jp
- European journal of pharmacology.Eur J Pharmacol.2011 Jul 1;661(1-3):57-62. Epub 2011 Apr 27.
- Emesis is the most feared side effect in patients who are undergoing cancer chemotherapy. In particular, cisplatin causes severe acute and delayed emesis. Although early vomiting is well controlled by 5-hydroxytryptamine 3 (5-HT(3)) receptor antagonists, delayed-phase vomiting is not sufficiently co
- PMID 21539837
Japanese Journal
- シクロスポリン点眼液のマウスTh2細胞結膜移入モデルにおける好酸球浸潤抑制作用
- Increasing Effect by Simultaneous Use of Levocabastine and Pemirolast on Experimental Allergic Conjunctivitis in Rats(Pharmacology)
- パクリタキセル過敏反応における知覚神経ペプチドの関与
- 福山大学薬学部研究年報 = Annual report of the Faculty of Pharmacy & Pharmaceutical Sciences, Fukuyama University 23, 21-39, 2005
- NAID 120005499909
Related Links
- Easy to read patient leaflet for pemirolast. Includes indications, proper use, special instructions, precautions, and possible side effects. ... If OVERDOSE is suspected: Contact 1-800-222-1222 (the American Association of Poison ...
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