overall
- adj.
- 全部の。端から端までの。総合的な、全般的な
- As long-term survival in ALL improves, more children experience late adverse effects including CNS imparirment, decreased linear growth, cardiotoxicity, infertility, and an increased incidence of secondary cancers, al well as an overall decreased health status due to such factors as neurocognitive dysfunction, depression, fatigue, and anxiety.