代謝中間体

WordNet

lying between two extremes in time or space or state; "going from sitting to standing without intermediate pushes with the hands"; "intermediate stages in a process"; "intermediate stops on the route"; "an intermediate range plane"
a substance formed during a chemical process before the desired product is obtained
of or relating to metabolism; "metabolic rate"
undergoing metamorphosis (同)metabolous

PrepTutorEJDIC

(程度・距離・時間などにおいて)中間の,中間にある(起こる)
新陳代謝の

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/12/24 10:33:55」(JST)

wiki en

Metabolic intermediates refers to molecules which are the precursors or metabolites of biologically significant molecules.

Although these intermediates are of relatively minor direct importance to cellular function, they can play important roles in the allosteric regulation of enzymes.

Clinical significance

Some can be useful in measuring rates of metabolic processes (for example, 3,4-dihydroxyphenylacetic acid or 3-aminoisobutyrate).

Because they can represent unnatural points of entry into natural metabolic pathways, some (such as AICA ribonucleotide) are of interest to researchers in developing new therapies.

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1. 妊娠への母体の適応：内分泌系と代謝の変化 maternal adaptations to pregnancy endocrine and metabolic changes
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3. メープルシロップ尿症の概要 overview of maple syrup urine disease
4. ピルビン酸キナーゼ欠損症 pyruvate kinase deficiency
5. Gestational diabetes mellitus: Glycemic control and maternal prognosis

English Journal

Worldwide uptake of FRAX.

Kanis JA1, Johansson H, Oden A, Cooper C, McCloskey EV; Epidemiology and Quality of Life Working Group of IOF.Collaborators (21)Kanis JA, Cooper C, Adachi J, Borgström F, Clark P, Cummings S, Diaz-Curiel M, Dimai HP, Harvey N, Hiligsmann M, Lau E, Lewiecki M, Lips P, Lorenc R, McCloskey E, Ortolani S, Papioannou A, Silverman S, Sosa M, Szulc P, Yoshimura N.
Archives of osteoporosis.Arch Osteoporos.2014 Dec;9(1):166. doi: 10.1007/s11657-013-0166-8. Epub 2014 Jan 14.
The worldwide uptake of FRAX is described.INTRODUCTION: The aim of this report was to determine the usage of FRAX worldwide over a 1-year period from 1 May 2012.METHODS: The number of FRAX calculations from each country was assessed over a 1-year period and expressed as calculations per million of t
PMID 24420978

Identifying the proton transfer reaction mechanism via a proton-bound dimeric intermediate for esomeprazoles by a kinetic method combined with density functional theory calculations.

Cao X1, Zhang F, Zhu K, Ye X, Shen L, Chen J, Mo W.Author information 1Research Center of Analysis and Measurement, Zhejiang University of Technology, 18 Chaowang Rd, Hangzhou, Zhejiang, 310014, P.R. China.AbstractRATIONALE: Esomeprazole analogs are a class of important proton pump inhibitors for the treatment of gastro-esophageal reflux diseases. Understanding the fragmentation reaction mechanism of the protonated esomeprazole analogs will facilitate the characterization of their complex metabolic fate in humans. In this paper, the kinetic method and theoretical calculations were applied to evaluate the fragmentation of protonated esomeprazole analogs.
Rapid communications in mass spectrometry : RCM.Rapid Commun Mass Spectrom.2014 May 15;28(9):1045-50. doi: 10.1002/rcm.6877.
RATIONALE: Esomeprazole analogs are a class of important proton pump inhibitors for the treatment of gastro-esophageal reflux diseases. Understanding the fragmentation reaction mechanism of the protonated esomeprazole analogs will facilitate the characterization of their complex metabolic fate in hu
PMID 24677526

Sphingosine 1-phosphate is a key metabolite linking sphingolipids to glycerophospholipids.

Kihara A.Author information Laboratory of Biochemistry, Faculty of Pharmaceutical Sciences, Hokkaido University, Kita 12-jo, Nishi 6-chome, Kita-ku, Sapporo 060-0812, Japan. Electronic address: kihara@pharm.hokudai.ac.jp.AbstractThe sphingolipid metabolite sphingosine 1-phosphate (S1P) is a well-known lipid mediator. As a lipid mediator, S1P must be present in extracellular space and bind to its cell surface receptors (S1P1-5). However, most S1P, synthesized intracellularly, is metabolized without being released into extracellular space, in other words, without functioning as a lipid mediator in the vast majority of cells except those supplying plasma and lymph S1P such as blood cells and endothelial cells. Instead, intracellular S1P plays an important role as an intermediate of the sole sphingolipid-to-glycerophospholipid metabolic pathway. The degradation of S1P by S1P lyase is the first irreversible reaction (committed step) of this pathway. This metabolic pathway is conserved in eukaryotes from yeast to human, indicating its much older origin than the function of S1P as a lipid mediator, which is found to be present only in vertebrates and chordates. The sphingolipid-to-glycerophospholipid metabolism takes place ubiquitously in mammalian tissues, and its defect causes an aberration of several tissue functions as well as abnormal lipid metabolism. Although this metabolic pathway has been known for over four decades, only recently the precise reactions and enzymes involved in this pathway have been revealed. This review will focus on the recent advances in our understanding of the sphingolipid metabolic pathway via S1P and its physiological and pathological roles. This article is part of a Special Issue entitled New Frontiers in Sphingolipid Biology.
Biochimica et biophysica acta.Biochim Biophys Acta.2014 May;1841(5):766-772. doi: 10.1016/j.bbalip.2013.08.014. Epub 2013 Aug 27.
The sphingolipid metabolite sphingosine 1-phosphate (S1P) is a well-known lipid mediator. As a lipid mediator, S1P must be present in extracellular space and bind to its cell surface receptors (S1P1-5). However, most S1P, synthesized intracellularly, is metabolized without being released into extrac
PMID 23994042

Japanese Journal

Improvement of (R)-1,3-butanediol production by engineered Escherichia coli(GENETICS, MOLECULAR BIOLOGY, AND GENE ENGINEERING)

Kataoka Naoya,Vangnai Alisa S.,Tajima Takahisa,Nakashimada Yutaka,Kato Junichi
Journal of bioscience and bioengineering 115(5), 475-480, 2013-05-00
… (R)-1,3-Butanediol is a valuable chemical extensively used as a key intermediate for the synthesis of pharmaceuticals and several industrial compounds. …
NAID 110009611448

Thermoplastic Polyesters of 2-Pyrone-4,6-Dicarboxylic Acid (PDC) Obtained from a Metabolic Intermediate of Lignin

Shikinaka Kazuhiro,Hashimoto Yoshiki,Kajita Shinya [他]
Fiber = 繊維学会誌 : journal of the Society of Fiber Science and Technology, Japan 69(2), 39-47, 2013-02-00
NAID 40019570217