mesonephroma

中腎腫

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/06/09 21:06:33」(JST)

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Clear-cell adenocarcinoma of the vagina
Classification and external resources
ICD-O	8310/3
DiseasesDB	2786
MeSH	D018262

Clear-cell adenocarcinoma (CCA) of the vagina (or cervix) is a rare Adenocarcinoma (cancer) often linked to diethylstilbestrol (DES), a drug which was prescribed in the mistaken belief that it prevented miscarriage and ensured a healthy pregnancy.

History

The synthetic estrogen DES was given to millions of pregnant women in the United States and other countries. Use in the US was primarily from 1938-1971 but not limited to those years. Internationally, DES use continued until the early 1980s. DES was given if a woman had a previous miscarriage, diabetes, or a problem-pregnancy with bleeding, threatened miscarriage or premature labor.

Up until the mid to late 1950s some women were given DES shots. After that, DES was primarily prescribed in pill form. DES also was included in some prenatal vitamins.

In the late 1960s through 1971 a cluster of young women, from their teens into their twenties, was mysteriously diagnosed with CCA, a cancer not generally found in women until after menopause. Doctors at Massachusetts General Hospital in Boston eventually linked DES exposure before birth to the development of CCA in these young woman. They determined the risk for developing CCA among so-called DES Daughters is small, estimated at 1 in a 1,000.

Clinical features

After age 30 it was thought DES Daughters no longer were at risk for the disease, but as they age into their 40s and 50, cases continue to be reported. Researchers are now watching for a possible spike of CCA cases in post-menopausal DES Daughters, since this is when this cancer is normally diagnosed.

According to the Centers for Disease Control and Prevention (CDC), DES Daughters should have a special pap/pelvic exam every year because of their lifelong risk for clear-cell adenocarcinoma. The screening is similar to a routine exam but is more comprehensive and should be done every year for DES Daughters even after a hysterectomy. Although the cervix was removed in surgery, the vagina remains, and should be examined for the possible development of CCA. Updated screening guidelines in 2012 allow some women to skip annual Paps. But in developing the guidelines, the United States Preventative Services Task Force (USPSTF) specifically spelled out that the guidelines do NOT apply to DES Daughters, who should continue having annual screenings.

Nomenclature

Clear cells are rich in glycogen, which accounts for their histology.

See Also

• Glassy cell carcinoma of the cervix

References

External links

• Clear cell adenocarcinoma entry in the public domain NCI Dictionary of Cancer Terms

• DES Action USA [1] national consumer organization providing comprehensive information for DES-exposed individuals

 This article incorporates public domain material from the U.S. National Cancer Institute document "Dictionary of Cancer Terms".

English Journal

• Solid pattern yolk sac tumor: a morphologic and immunohistochemical study of 52 cases.

• Kao CS, Idrees MT, Young RH, Ulbright TM.SourceDepartment of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
• The American journal of surgical pathology.Am J Surg Pathol.2012 Mar;36(3):360-7. doi: 10.1097/PAS.0b013e31823c510b.
• Yolk sac tumors may exhibit numerous patterns. One that has received little attention overall, yet is not uncommon, is a solid pattern, which is especially prone to misinterpretation, usually as seminoma, in biopsy specimens from metastatic or mediastinal sites. This distinction is of critical impor
• PMID 22261704

• Functional interaction between peritoneal mesothelial cells and stem cells of ovarian yolk sac tumor (SC-OYST) in peritoneal dissemination.

• Mitsui H, Shibata K, Suzuki S, Umezu T, Mizuno M, Kajiyama H, Kikkawa F.SourceDepartment of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
• Gynecologic oncology.Gynecol Oncol.2012 Feb;124(2):303-10. Epub 2011 Oct 29.
• OBJECTIVE: In recent years it has been indicated that ecological niches play important roles in the maintenance of cancer stem cells (CSCs). We investigated interactions between peritoneal mesothelial cells and SC-OYST based on the hypothesis that peritoneal mesothelial cells have the potential to p
• PMID 22040835

Japanese Journal

• Malignant mesonephroma の1例 : 第112回熊本地方会

• 日本泌尿器科學會雜誌 75(3), 552-553, 1984
• NAID 110003082404

• 喀痰中に卵巣中腎腫細胞が見出された稀な1例

• 日本臨床細胞学会雑誌 19(4), 557-560, 1980-10-25
• NAID 110001253706

• 喀痰中に卵巣中腎腫細胞が見出された稀な1例

• 日本臨床細胞学会雑誌 19(4), 557-560, 1980
• NAID 130003925391

Related Links

• Mesonephroma | definition of mesonephroma by Medical ...

mesonephroma [mez″o-nĕ-fro´mah] clear cell adenocarcinoma. mes·o·ne·phro·ma (mez'ō-ne-frō'mă), Obsolete term for a relatively rare malignant neoplasm of the ovary and corpus uteri, thought to originate in mesonephric structures ...

• Mesonephroma | Define Mesonephroma at Dictionary.com

mesonephroma mes·o·ne·phro·ma (měz'ō-nə-frō'mə, měs'-) n. Any of various rare tumors possibly derived from the mesonephros and occurring in the genital tract. Also called mesometanephric carcinoma.

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