レバロルファン
WordNet
- drug (trade name Lorfan) that is related to morphine but that counteracts the respiratory depression produced by morphine poisoning but without affecting its analgesic effects (同)Lorfan
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2017/04/11 20:54:40」(JST)
[Wiki en表示]
Levallorphan
|
Clinical data |
AHFS/Drugs.com |
International Drug Names |
Routes of
administration |
Oral |
ATC code |
|
Legal status |
Legal status |
- In general: ℞ (Prescription only)
|
Identifiers |
IUPAC name
- (−)-17-allylmorphinan-3-ol
|
CAS Number |
|
PubChem CID |
|
IUPHAR/BPS |
|
DrugBank |
|
ChemSpider |
|
UNII |
|
ChEMBL |
|
ECHA InfoCard |
100.005.273 |
Chemical and physical data |
Formula |
C19H25NO |
Molar mass |
283.4079 g/mol |
3D model (Jmol) |
|
SMILES
-
Oc1ccc3c(c1)[C@@]24[C@H]([C@H](N(CC2)C\C=C)C3)CCCC4
|
InChI
-
InChI=1S/C19H25NO/c1-2-10-20-11-9-19-8-4-3-5-16(19)18(20)12-14-6-7-15(21)13-17(14)19/h2,6-7,13,16,18,21H,1,3-5,8-12H2/t16-,18-,19-/m0/s1 Y
-
Key:OZYUPQUCAUTOBP-WDSOQIARSA-N Y
|
NY (what is this?) (verify) |
Levallorphan (INN, BAN) (brand names Lorfan, Naloxifan, Naloxiphan), also known as levallorphan tartrate (USAN), is an opioid modulator of the morphinan family used as an opioid analgesic and opioid antagonist/antidote.[1][2][3] It acts as an antagonist of the μ-opioid receptor (MOR) and as an agonist of the κ-opioid receptor (KOR),[4] and as a result, blocks the effects of stronger agents with greater intrinsic activity such as morphine whilst simultaneously producing analgesia.[5]
Levallorphan was formerly widely used in general anesthesia, mainly to reverse the respiratory depression produced by opioid analgesics and barbiturates used for induction of surgical anaesthesia whilst maintaining a degree of analgesia (via KOR agonism). It is now less commonly employed for this purpose as the newer drug naloxone tends to be used instead. Levallorphan was also used in combination with opioid analgesics to reduce their side effects, mainly in obstetrics, and a very small dose of levallorphan used alongside a full agonist of the MOR can produce greater analgesia than when the latter is used by itself.[6] The combination of levallorphan with pethidine (meperidine) was indeed used so frequently, a standardized formulation was made available, known as Pethilorfan.[7]
As an agonist of the KOR, levallorphan can produce severe mental reactions at sufficient doses including hallucinations, dissociation, and other psychotomimetic effects, dysphoria, anxiety, confusion, dizziness, disorientation, derealization, feelings of drunkenness, and bizarre, unusual, or disturbing dreams.[8][9][10]
See also
- Butorphanol
- Cyclorphan
- Dextrallorphan
- Levomethorphan
- Levorphanol
- Nalbuphine
- Nalodeine
- Nalorphine
- Oxilorphan
- Proxorphan
- Samidorphan
- Xorphanol
References
- ^ J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 731–. ISBN 978-1-4757-2085-3.
- ^ Swiss Pharmaceutical Society (2000). Index Nominum 2000: International Drug Directory (Book with CD-ROM). Boca Raton: Medpharm Scientific Publishers. ISBN 3-88763-075-0.
- ^ I.K. Morton; Judith M. Hall (6 December 2012). Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science & Business Media. pp. 164–. ISBN 978-94-011-4439-1.
- ^ Goodman & Gilman. The Pharmacological Basis of Therapeutics (10th ed.). McGraw Hill Medical Publishing. p. 602. ISBN 978-0-07-135469-1.
- ^ Codd, E. E.; Shank, R. P.; Schupsky, J. J.; Raffa, R. B. (September 1995). "Serotonin and norepinephrine uptake inhibiting activity of centrally acting analgesics: structural determinants and role in antinociception". The Journal of Pharmacology and Experimental Therapeutics. 274 (3): 1263–1270. PMID 7562497.
- ^ Bullough, J. (1959). "Use of premixed pethidine and antagonists in obstetrical analgesia; with special reference to cases in which levallorphan was used" (pdf). British Medical Journal. 2 (5156): 859–862. doi:10.1136/bmj.2.5156.859. PMC 1990381. PMID 13805887.
- ^ Williams, G.; Cope, I. (1962). "An evaluation of a combination of pethidine and levallorphan ("pethilorfan") in labour". The Medical Journal of Australia. 49 (2): 499–503. PMID 14000851.
- ^ R.C.W. Hall (6 December 2012). Psychiatric Presentations of Medical Illness: Somatopsychic Disorders. Springer Science & Business Media. pp. 364–. ISBN 978-94-011-7677-4.
- ^ American Hospital Formulary Service Drug Information. authority of the Board of Directors of the American Society of Hospital Pharmacists. 1984. p. 664.
- ^ John B. Williams (1963). Narcotics. Wm. C. Brown Company. p. 203.
Analgesics (N02A, N02B)
|
|
Opioids |
Opiates/opium |
- Codeine# (+paracetamol, +aspirin)
- Morphine# (+naltrexone)
- Opium
- Laudanum
- Paregoric
|
|
Semisynthetic |
- Acetyldihydrocodeine
- Benzylmorphine
- Buprenorphine (+naloxone)
- Desomorphine
- Diamorphine (heroin)
- Dihydrocodeine (+paracetamol)
- Dihydromorphine
- Ethylmorphine
- Hydrocodone (+paracetamol, +ibuprofen, +aspirin)
- Hydromorphinol
- Hydromorphone
- Nicocodeine
- Nicodicodeine
- Nicomorphine
- Oxycodone (+paracetamol, +aspirin, +ibuprofen, +naloxone, +naltrexone)
- Oxymorphone
- Thebacon
|
|
Synthetic |
- Alphaprodine
- Anileridine
- Butorphanol
- Dextromoramide
- Dextropropoxyphene
- Dezocine
- Fentanyl (+fluanisone)
- Ketobemidone
- Levorphanol
- Meptazinol
- Methadone
- Nalbuphine
- NFEPP
- Pentazocine
- Pethidine
- Phenadoxone
- Phenazocine
- Piminodine
- Piritramide
- Propiram
- Tapentadol
- Tilidine
- Tramadol
|
|
|
Paracetamol-type |
- Acetanilide‡
- Bucetin‡
- Butacetin‡
- Paracetamol (acetaminophen)#
- Parapropamol‡
- Phenacetin‡
- Propacetamol‡
|
|
NSAIDs |
Propionates |
- Fenoprofen
- Flurbiprofen
- Ibuprofen#
- Ketoprofen
- Naproxen
- Oxaprozin
|
|
Oxicams |
|
|
Acetates |
- Diclofenac
- Indometacin
- Ketorolac
- Nabumetone
- Sulindac
- Tolmetin
|
|
COX-2 inhibitors |
- Celecoxib
- Etoricoxib
- Lumiracoxib
- Parecoxib
- Rofecoxib ‡
- Valdecoxib ‡
|
|
Fenamates |
- Meclofenamic acid
- Mefenamic acid
|
|
Salicylates |
- Aspirin (acetylsalicylic acid)# (+paracetamol/caffeine)
- Benorylate
- Diflunisal
- Ethenzamide
- Magnesium salicylate
- Salicin
- Salicylamide
- Salsalate
- Wintergreen (methyl salicylate)
|
|
Pyrazolones |
- Aminophenazone‡
- Ampyrone
- Metamizole (dipyrone)
- Nifenazone
- Phenazone
- Propyphenazone (+paracetamol/caffeine)
|
|
Others |
|
|
|
Cannabinoids |
- Cannabidiol
- Cannabis
- Nabilone
- Nabiximols
- Tetrahydrocannabinol (dronabinol)
|
|
Ion channel
modulators |
Calcium blockers |
- Gabapentin
- Gabapentin enacarbil
- Pregabalin
- Ziconotide
|
|
Sodium blockers |
- Carbamazepine
- Lacosamide
- Local anesthetics (e.g., cocaine, lidocaine)
- Mexiletine
- Nefopam
- Tricyclic antidepressants (e.g., amitriptyline#)
- Nav1.7/1.8-selective: DSP-2230§
- Funapide§
- PF-05089771§
- Raxatrigine§
|
|
Potassium openers |
|
|
|
Myorelaxants |
- Carisoprodol
- Chlorzoxazone
- Cyclobenzaprine
- Mephenoxalone
- Methocarbamol
- Orphenadrine
|
|
Others |
- Camphor
- Capsaicin
- Clonidine
- Ketamine
- Menthol
- Methoxyflurane
- Nefopam
- Proglumide
- Tricyclic antidepressants (e.g., amitriptyline#)
|
|
-
- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
|
Antidotes (V03AB)
|
|
Nervous
system |
Nerve agent /
Organophosphate
poisoning
|
- Atropine#
- Biperiden
- Diazepam#
- Oximes
- see also: Cholinesterase
|
|
Barbiturate
overdose
|
|
|
Benzodiazepine
overdose
|
|
|
GHB overdose
|
|
|
Opioid overdose
|
- Diprenorphine
- Doxapram
- Nalmefene
- Nalorphine
- Naloxone#
- Naltrexone
|
|
Reversal of
neuromuscular blockade
|
|
|
|
Circulatory
system |
Beta blocker
|
|
|
Digoxin toxicity
|
|
|
Heparin
|
|
|
|
Other |
Arsenic poisoning
|
|
|
Cyanide poisoning
|
- 4-Dimethylaminophenol
- Hydroxocobalamin
- nitrite
- Amyl nitrite
- Sodium nitrite#
- Sodium thiosulfate#
|
|
Hydrofluoric acid
|
|
|
Methanol /
Ethylene glycol
poisoning
|
- Primary alcohols: Ethanol
- Fomepizole
|
|
Paracetamol toxicity
(Acetaminophen)
|
- Acetylcysteine#
- Glutathione
- Methionine#
|
|
|
- Dimercaprol#
- Edetates
- Prussian blue#
|
|
Other
|
- iodine-131
- Methylthioninium chloride#
- oxidizing agent
- Prednisolone/promethazine
|
|
|
Emetic |
- Copper sulfate
- Ipecacuanha
|
|
- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
|
Hallucinogens
|
|
Psychedelics
(5-HT2A
agonists) |
Lyserg‐
amides
|
- 1P-ETH-LAD
- 1P-LSD
- 2-Butyllysergamide
- 3-Pentyllysergamide
- AL-LAD
- ALD-52
- BU-LAD
- Diallyllysergamide
- Dimethyllysergamide
- Ergometrine
- ETH-LAD
- IP-LAD
- LAE-32
- LPD-824
- LSA
- LSD
- LSD-Pip
- LSH
- LSM-775
- LSZ
- Methylergometrine
- Methylisopropyllysergamide
- Methysergide
- MLD-41
- PARGY-LAD
- PRO-LAD
|
|
Phenethyl‐
amines
|
|
|
Piperazines
|
|
|
Tryptamines
|
|
- 4,5-DHP-α-MT
- 5-MeO-α-ET
- 5-MeO-α-MT
- α-ET
- α-MT
|
|
|
- 4,5-DHP-DMT
- 2,N,N-TMT
- 4-AcO-DMT
- 4-HO-5-MeO-DMT
- 4,N,N-TMT
- 4-Propionyloxy-DMT
- 5,6-diBr-DMT
- 5-AcO-DMT
- 5-Bromo-DMT
- 5-MeO-2,N,N-TMT
- 5-MeO-4,N,N-TMT
- 5-MeO-α,N,N-TMT
- 5-MeO-DMT
- 5-N,N-TMT
- 7,N,N-TMT
- α,N,N-TMT
- (Bufotenin) 5-HO-DMT
- DMT
- Norbaeocystin
- (Psilocin) 4-HO-DMT
- (Psilocybin) 4-PO-DMT
|
|
|
- (Ethacetin) 4-AcO-DET
- (Ethocin) 4-HO-DET
- 5-MeO-DET
- (T-9) DET
- (Ethocybin) 4-PO-DET
|
|
|
- (Depracetin) 4-AcO-DPT
- (Deprocin) 4-HO-DPT
- 5-MeO-DPT
- (The Light) DPT
|
|
|
- 1-Me-5-MeO-DiPT
- (Ipracetin) 4-AcO-DiPT
- (Iprocin) 4-HO-DiPT
- (Foxy Methoxy) 5-MeO-DiPT
- DiPT
|
|
|
- (Daltocin) 4-HO-DALT
- (Daltacetin) 4-AcO-DALT
- 5-MeO-DALT
- DALT
|
|
|
- (Metocin) 4-HO-MET
- (Metocetin) 4-AcO-MET
- 5-MeO-MET
- MET
|
|
|
- (Mipracetin) 4-AcO-MiPT
- (Miprocin) 4-HO-MiPT
- 5-Me-MiPT
- (Moxy) 5-MeO-MiPT
- MiPT
|
|
Subst.
Ibogamine
|
- Ibogaine
- Noribogaine
- Voacangine
|
|
Others
|
- 4-HO-DBT
- 4-HO-EPT
- 4-HO-McPT
- (Lucigenol) 4-HO-MPMI
- (Meprocin) 4-HO-MPT
- 5-MeO-EiPT
- 5-MeO-MALT
- 5-MeO-MPMI
- Aeruginascin
- Baeocystin
- DBT
- DCPT
- EiPT
- EPT
- MPT
- PiPT
|
|
|
Others
|
- 5-MeO-DiBF
- AL-38022A
- ALPHA
- Dimemebfe
- Efavirenz
- Lorcaserin
- M-ALPHA
- RH-34
Also empathogens in general (e. g.: 5-APB, 5-MAPB, 6-APB and other substituted benzofurans, MDAI, MDMA).
|
|
|
Dissociatives
(NMDAR
antagonists) |
Arylcyclo‐
hexylamines
|
- 2-Fluorodeschloroketamine
- 3-HO-PCP
- 3-MeO-PCE
- 3-MeO-PCMo
- 3-MeO-PCP
- 4-MeO-PCP
- Arketamine
- Deschloroketamine
- Dieticyclidine
- Esketamine
- Ethketamine
- Eticyclidine
- Gacyclidine
- Ketamine
- Methoxetamine
- Methoxmetamine
- Methoxyketamine
- Norketamine
- PCPr
- PCP
- Rolicyclidine
- Tenocyclidine
- Tiletamine
|
|
Morphinans
|
- Dextrallorphan
- Dextromethorphan
- Dextrorphan
- Racemethorphan
- Racemorphan
|
|
Diarylethylamines
|
- Diphenidine
- Ephenidine
- Fluorolintane
- Methoxphenidine
|
|
Others
|
- 2-MDP
- 8A-PDHQ
- Aptiganel
- Budipine
- Delucemine
- Dexoxadrol
- Dizocilpine
- Etoxadrol
- Ibogaine
- Midafotel
- NEFA
- Neramexane
- Nitrous oxide
- Noribogaine
- Perzinfotel
- Remacemide
- Selfotel
- Xenon
|
|
|
Deliriants
(mAChR
antagonists) |
- Atropine
- Benactyzine
- Benzatropine
- Benzydamine
- Biperiden
- BRN-1484501
- Brompheniramine
- BZ
- CAR-226,086
- CAR-301,060
- CAR-302,196
- CAR-302,282
- CAR-302,368
- CAR-302,537
- CAR-302,668
- Chloropyramine
- Chlorphenamine
- Clemastine
- CS-27349
- Cyclizine
- Cyproheptadine
- Dicycloverine
- Dimenhydrinate
- Diphenhydramine
- Ditran
- Doxylamine
- EA-3167
- EA-3443
- EA-3580
- EA-3834
- Elemicin
- Flavoxate
- Hyoscyamine
- JB-318
- JB-336
- Meclozine
- Mepyramine
- Myristicin
- Orphenadrine
- Oxybutynin
- Pheniramine
- Phenyltoloxamine
- Procyclidine
- Promethazine
- Scopolamine
- Tolterodine
- Trihexyphenidyl
- Tripelennamine
- Triprolidine
- WIN-2299
|
|
Others |
Cannabinoids
(CB1 agonists)
|
Natural
|
- Cannabinol
- THC (Dronabinol)
- THCV
|
|
Synthetic
|
|
|
|
D2 agonists
|
- Apomorphine
- Aporphine
- Bromocriptine
- Cabergoline
- Lisuride
- Memantine
- Nuciferine
- Pergolide
- Phenethylamine
- Piribedil
- Pramipexole
- Ropinirole
- Rotigotine
- Salvinorin A
Also indirect D2 agonists, such as dopamine reuptake inhibitors (cocaine, methylphenidate), releasing agents (amphetamine, methamphetamine), and precursors (levodopa).
|
|
GABAA
enhancers
|
- CI-966
- Eszopiclone
- Ibotenic acid
- Muscimol (Amanita muscaria)
- Zaleplon
- Zolpidem
- Zopiclone
|
|
Inhalants
(Mixed MOA)
|
- Aliphatic hydrocarbons
- Butane
- Gasoline
- Kerosene
- Propane
- Aromatic hydrocarbons
- Ethers
- Haloalkanes
- Chlorofluorocarbons
- Chloroform
|
|
κOR agonists
|
- 2-EMSB
- 2-MMSB
- Alazocine
- Bremazocine
- Butorphan
- Butorphanol
- Cyclazocine
- Cyclorphan
- Cyprenorphine
- Diprenorphine
- Enadoline
- Herkinorin
- Heroin
- HZ-2
- Ibogaine
- Ketazocine
- Levallorphan
- Levomethorphan
- Levorphanol
- LPK-26
- Metazocine
- Morphine
- Nalbuphine
- Nalmefene
- Nalorphine
- Noribogaine
- Oxilorphan
- Pentazocine
- Phenazocine
- Proxorphan
- Racemethorphan
- Racemorphan
- Salvinorin A
- Spiradoline
- Tifluadom
- U-50488
- U-69,593
- Xorphanol
|
|
Others
|
- Glaucine
- Isoaminile
- Noscapine
- Pukateine
|
|
Opioid receptor modulators
|
|
MOR |
|
|
DOR |
|
|
KOR |
- Agonists: 6'-GNTI
- 8-CAC
- 18-MC
- 14-Methoxymetopon
- β-Chlornaltrexamine
- β-Funaltrexamine
- Adrenorphin (metorphamide)
- Akuuamicine
- Alazocine
- Allomatrine
- Asimadoline
- BAM-12P
- BAM-18P
- BAM-22P
- Big dynorphin
- Bremazocine
- BRL-52537
- Butorphan
- Butorphanol
- BW-373U86
- Cebranopadol
- Ciprefadol
- CR665
- Cyclazocine
- Cyclorphan
- Cyprenorphine
- Diamorphine (heroin)
- Diacetylnalorphine
- Difelikefalin
- Dihydroetorphine
- Dihydromorphine
- Diprenorphine
- Dynorphin A
- Dynorphin B (rimorphin)
- Eluxadoline
- Enadoline
- Eptazocine
- Erinacine E
- Ethylketazocine
- Etorphine
- Fedotozine
- Fentanyl
- Gemazocine
- GR-89696
- GR-103545
- Hemorphin-4
- Herkinorin
- HS665
- Hydromorphone
- HZ-2
- Ibogaine
- ICI-199,441
- ICI-204,448
- Ketamine
- Ketazocine
- Laudanosine
- Leumorphin (dynorphin B-29)
- Levallorphan
- Levomethorphan
- Levorphanol
- Lexanopadol
- Lofentanil
- LPK-26
- Lufuradom
- Matrine
- MB-1C-OH
- Menthol
- Metazocine
- Metkefamide
- Mianserin
- Mirtazapine
- Morphine
- Moxazocine
- MR-2034
- N-MPPP
- Nalbuphine
- Nalbuphine sebacate
- NalBzOH
- Nalfurafine
- Nalmefene
- Nalodeine (N-allylnorcodeine)
- Nalorphine
- Naltriben
- Niravoline
- Norbuprenorphine
- Norbuprenorphine-3-glucuronide
- Noribogaine
- Norketamine
- O-Desmethyltramadol
- Oripavine
- Oxilorphan
- Oxycodone
- Pentazocine
- Pethidine (meperidine)
- Phenazocine
- Proxorphan
- Racemethorphan
- Racemorphan
- RB-64
- Salvinorin A (salvia)
- Salvinorin B ethoxymethyl ether
- Salvinorin B methoxymethyl ether
- Samidorphan
- SKF-10047
- Spiradoline (U-62,066)
- TH-030418
- Thienorphine
- Tifluadom
- Tricyclic antidepressants (e.g., amitriptyline, desipramine, imipramine, nortriptyline)
- U-50,488
- U-54,494A
- U-69,593
- Xorphanol
- Antagonists: 4′-Hydroxyflavanone
- 4',7-Dihydroxyflavone
- 5'-GNTI
- 6'-GNTI
- 6β-Naltrexol
- 6β-Naltrexol-d4
- β-Chlornaltrexamine
- Buprenorphine/samidorphan
- Amentoflavone
- ANTI
- Apigenin
- Arodyne
- AT-076
- Axelopran
- AZ-MTAB
- Binaltorphimine
- BU09059
- Buprenorphine
- Catechin
- Catechin gallate
- CERC-501 (LY-2456302)
- Clocinnamox
- Cyclofoxy
- Dezocine
- DIPPA
- EGC
- ECG
- Epicatechin
- Hyperoside
- JDTic
- LY-255582
- LY-2196044
- LY-2444296
- LY-2459989
- LY-2795050
- MeJDTic
- Methylnaltrexone
- ML190
- ML350
- MR-2266
- N-Fluoropropyl-JDTic
- Naloxone
- Naltrexone
- Naltrindole
- Naringenin
- Norbinaltorphimine
- Noribogaine
- Pawhuskin A
- PF-4455242
- RB-64
- Quadazocine
- Taxifolin
- UPHIT
- Zyklophin
- Unknown/unsorted: Akuammicine
- Akuammine
- Coronaridine
- Cyproterone acetate
- Dihydroakuuamine
- Ibogamine
- Tabernanthine
|
|
NOP |
- Agonists: (Arg14,Lys15)Nociceptin
- ((pF)Phe4)Nociceptin(1-13)NH2
- (Phe1Ψ(CH2-NH)Gly2)Nociceptin(1-13)NH2
- Ac-RYYRWK-NH2
- Ac-RYYRIK-NH2
- BU08070
- Buprenorphine
- Cebranopadol
- Dihydroetorphine
- Etorphine
- JNJ-19385899
- Levomethorphan
- Levorphanol
- Levorphanol
- Lexanopadol
- MCOPPB
- MT-7716
- NNC 63-0532
- Nociceptin (orphanin FQ)
- Nociceptin (1-11)
- Nociceptin (1-13)NH2
- Norbuprenorphine
- Racemethorphan
- Racemorphan
- Ro64-6198
- Ro65-6570
- SCH-221510
- SCH-486757
- SR-8993
- SR-16435
- TH-030418
- Antagonists: (Nphe1)Nociceptin(1-13)NH2
- AT-076
- BAN-ORL-24
- J-113397
- JTC-801
- LY-2940094
- NalBzOH
- Nociceptin (1-7)
- Nocistatin
- SB-612111
- SR-16430
- Thienorphine
- Trap-101
- UFP-101
|
|
Unsorted |
- β-Casomorphins
- Amidorphin
- BAM-20P
- Cytochrophin-4
- Deprolorphin
- Gliadorphin (gluteomorphin)
- Gluten exorphins
- Hemorphins
- Kava constituents
- MEAGL
- MEAP
- NEM
- Neoendorphins
- Nepetalactone (catnip)
- Peptide B
- Peptide E
- Peptide F
- Peptide I
- Rubiscolins
- Soymorphins
|
|
Others |
- Enkephalinase inhibitors: Amastatin
- BL-2401
- Candoxatril
- D -Phenylalanine
- Dexecadotril (retorphan)
- Ecadotril (sinorphan)
- Kelatorphan
- Racecadotril (acetorphan)
- RB-101
- RB-120
- RB-3007
- Opiorphan
- Selank
- Semax
- Spinorphin
- Thiorphan
- Tynorphin
- Ubenimex (bestatin)
- Propeptides: β-Lipotropin (proendorphin)
- Prodynorphin
- Proenkephalin
- Pronociceptin
- Proopiomelanocortin (POMC)
- Others: Kyotorphin (met-enkephalin releaser/degradation stabilizer)
|
|
See also: Peptide receptor modulators
|
English Journal
- Microfabricated electrochemical detector for high-performance liquid chromatography.
- Ogburn ET1, Dziewatkoski M, Moles D, Johnson JM, Heineman WR.
- Analytical chemistry.Anal Chem.2011 Sep 15;83(18):6963-70. doi: 10.1021/ac200476j. Epub 2011 Aug 18.
- A microfabricated electrochemical cell has been developed as a disposable detector for flow injection analysis (FIA) and high-performance liquid chromatography (HPLC). The simplicity of the fabrication process allows this detector to be used as a low-cost, disposable device that can be replaced easi
- PMID 21598939
- Inhibition of morphine-induced cAMP overshoot: a cell-based assay model in a high-throughput format.
- Xia M1, Guo V, Huang R, Shahane SA, Austin CP, Nirenberg M, Sharma SK.
- Cellular and molecular neurobiology.Cell Mol Neurobiol.2011 Aug;31(6):901-7. doi: 10.1007/s10571-011-9689-y. Epub 2011 May 20.
- Opiates are not only potent analgesics but also drugs of abuse mainly because they produce euphoria. Chronic use of opiates results in the development of tolerance and dependence. Dr Marshall Nirenberg's group at the National Institutes of Health (NIH) was the first to use a cellular model system of
- PMID 21598037
- Exploration of catalytic properties of CYP2D6 and CYP3A4 through metabolic studies of levorphanol and levallorphan.
- Bonn B1, Masimirembwa CM, Castagnoli N Jr.
- Drug metabolism and disposition: the biological fate of chemicals.Drug Metab Dispos.2010 Jan;38(1):187-99. doi: 10.1124/dmd.109.028670.
- CYP2D6 and CYP3A4, two members of the cytochrome P450 superfamily of monooxygenases, mediate the biotransformation of a variety of xenobiotics. The two enzymes differ in substrate specificity and size and characteristics of the active site cavity. The aim of this study was to determine whether the c
- PMID 19797609
Japanese Journal
Related Links
- Levallorphan (Lorfan, Naloxiphan) is a drug of the morphinan family which is used as an opioid antidote or antagonist. It acts as an antagonist on μ-opioid receptor and agonist on kappa receptors hence called partial agonist, and as a result, ...
- 13 Jun 2005 ... It should be used cautiously; levallorphan reverses severe opioid-induced respiratory depression but may exacerbate respiratory depression such as that induced by alcohol or other non-opioid central depressants.
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★リンクテーブル★
[★]
- 英
- levallorphan
- 化
- 酒石酸レバロルファン levallorphan tartrate
- 商
- ロルファン注射液、ペチロルファン
- 関
- オピオイド受容体、麻薬性鎮痛薬
[★]
レバロルファン、酒石酸レバロルファン