メチルマロン酸

英

methylmalonic acid MMA

関

メチルマロン酸尿症、メチルマロニルCoA

• HOOC-CH(CH₃)-COOH

• http://en.wikipedia.org/wiki/Methylmalonic_acid
• Increased methylmalonic acid levels may indicate a vitamin B12 deficiency. However, it is sensitive without being specific. *MMA is elevated in 90-98% of patients with B12 deficiency. This test may be overly sensitive, as 25-20% of patients over the age of 70 have elevated levels of MMA, but 25-33% of them do not have B12 deficiency. For this reason, MMA is not routinely recommended in the elderly.

• An excess is associated with methylmalonic acidemia.

臨床関連

• メチルマロン酸尿症