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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/12/05 12:40:21」(JST)

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β-マンノシダーゼ(Beta-Mannosidase、EC 3.2.1.25)は、β-D-マンノシドの非還元末端からβ-D-マンノースを切り出す酵素である。系統名は、β-D-マンノシドマンノヒドロラーゼ(beta-D-mannoside mannohydrolase)。である。マンナナーゼ(mannanase)、マンナーゼ(mannase)等とも言う。ヒトでは、MANBA遺伝子がコードする^[1]^[2]^[3]^[4]^[5]^[6]。

この遺伝子は、GHファミリー2の酵素をコードする。コードされた蛋白質はリソソームに局在し、ここで、N-結合オリゴ糖の異化経路の最後のエキソグリコシダーゼとして働く。この遺伝子の変異は、幅広い神経障害を引き起こすリソソーム蓄積症であるβ-マンノシドーソスを引き起こす^[1]。

出典

^ ^a ^b “Entrez Gene: mannosidase”. 2013年8月17日閲覧。
^ Chen H, Leipprandt JR, Traviss CE, Sopher BL, Jones MZ, Cavanagh KT, Friderici KH (February 1995). “Molecular cloning and characterization of bovine beta-mannosidase”. J. Biol. Chem. 270 (8): 3841–8. doi:10.1074/jbc.270.8.3841. PMID 7876128.
^ Adams, M., Richtmyer, N.K. and Hudson, C.S. (1943). “Some enzymes present in highly purified invertase preparations; a contribution to the study of fructofuranosidases, galactosidases, glucosidases and mannosidases”. J. Am. Chem. Soc. 65 (7): 1369–1380. doi:10.1021/ja01247a029.
^ Bartholomew, B.A. and Perry, A.L. (1973). “The properties of synovial fluid β-mannosidase activity”. Biochim. Biophys. Acta 315 (1): 123–127. doi:10.1016/0005-2744(73)90136-8. PMID 4743897.
^ Deuel, H., Lewuenberger, R. and Huber, G. (1950). “Über den enzymatischen Abbau von Carubin, dem Galaktomannan aus Ceratonia siliqua L”. Helv. Chim. Acta 33 (4): 942–946. doi:10.1002/hlca.19500330424.
^ Hylin, J.W. and Sawai, K. (1964). “The enzymatic hydrolysis of Leucaena glauca galactomannan. Isolation of crystalline galactomannan depolymerase”. J. Biol. Chem. 239: 990–992. PMID 14165949.

関連文献

Bolmstedt A, Sjölander S, Hansen JE, et al. (1996). “Influence of N-linked glycans in V4-V5 region of human immunodeficiency virus type 1 glycoprotein gp160 on induction of a virus-neutralizing humoral response”. J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 12 (3): 213–20. doi:10.1097/00042560-199607000-00001. PMID 8673525.
Kalsi G, Kuo PH, Aliev F, et al. (2010). “A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts”. Hum. Mol. Genet. 19 (12): 2497–506. doi:10.1093/hmg/ddq112. PMC 2876884. PMID 20332099.
Levade T, Graber D, Flurin V, et al. (1994). “Human beta-mannosidase deficiency associated with peripheral neuropathy”. Ann. Neurol. 35 (1): 116–9. doi:10.1002/ana.410350119. PMID 8285582.
Hu H, Shioda T, Moriya C, et al. (1996). “Infectivities of human and other primate lentiviruses are activated by desialylation of the virion surface”. J. Virol. 70 (11): 7462–70. PMC 190813. PMID 8892864.
Yeh JC, Seals JR, Murphy CI, et al. (1993). “Site-specific N-glycosylation and oligosaccharide structures of recombinant HIV-1 gp120 derived from a baculovirus expression system”. Biochemistry 32 (41): 11087–99. doi:10.1021/bi00092a019. PMID 8218172.
Sabourdy F, Labauge P, Stensland HM, et al. (2009). “A MANBA mutation resulting in residual beta-mannosidase activity associated with severe leukoencephalopathy: a possible pseudodeficiency variant”. BMC Med. Genet. 10: 84. doi:10.1186/1471-2350-10-84. PMC 2745377. PMID 19728872.
Hosgood HD, Zhang L, Shen M, et al. (2009). “Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity”. Occup Environ Med 66 (12): 848–53. doi:10.1136/oem.2008.044024. PMC 2928224. PMID 19773279.
Alkhayat AH, Kraemer SA, Leipprandt JR, et al. (1998). “Human beta-mannosidase cDNA characterization and first identification of a mutation associated with human beta-mannosidosis”. Hum. Mol. Genet. 7 (1): 75–83. doi:10.1093/hmg/7.1.75. PMID 9384606.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). “Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes”. Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Papandreou MJ, Fenouillet E (1997). “Effect of various glycosidase treatments on the resistance of the HIV-1 envelope to degradation”. FEBS Lett. 406 (1–2): 191–5. doi:10.1016/S0014-5793(97)00273-1. PMID 9109416.
Gao J, Arbman G, He L, et al. (2008). “MANBA polymorphism was related to increased risk of colorectal cancer in Swedish but not in Chinese populations”. Acta Oncol 47 (3): 372–8. doi:10.1080/02841860701644052. PMID 17899454.
Robinson WE, Montefiori DC, Mitchell WM (1987). “Evidence that mannosyl residues are involved in human immunodeficiency virus type 1 (HIV-1) pathogenesis”. AIDS Res. Hum. Retroviruses 3 (3): 265–82. doi:10.1089/aid.1987.3.265. PMID 2829950.
Montefiori DC, Robinson WE, Mitchell WM (1988). “Role of protein N-glycosylation in pathogenesis of human immunodeficiency virus type 1”. Proc. Natl. Acad. Sci. U.S.A. 85 (23): 9248–52. doi:10.1073/pnas.85.23.9248. PMC 282716. PMID 3264072.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Fenouillet E, Jones I, Powell B, et al. (1993). “Functional role of the glycan cluster of the human immunodeficiency virus type 1 transmembrane glycoprotein (gp41) ectodomain”. J. Virol. 67 (1): 150–60. PMC 237347. PMID 8093218.
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★リンクテーブル★

リンク元	「βマンノシダーゼ」
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「βマンノシダーゼ」

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PMC	articles
PubMed	articles
NCBI	proteins

β-マンノシダーゼ
識別子
EC番号	3.2.1.25
CAS登録番号	9025-43-8
データベース
IntEnz	IntEnz view
BRENDA（英語版）	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB構造	RCSB PDB PDBe PDBj PDBsum
遺伝子オントロジー	AmiGO / EGO
検索
PMC	articles
PubMed	articles
NCBI	proteins