WordNet
- any substance (as a toxin or enzyme) that stimulates an immune response in the body (especially the production of antibodies)
- denoting or relating to cells or tissues from individuals belonging to different species
PrepTutorEJDIC
- 抗原(生物の体内にはいって免疫体を作る物質)
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- 1. 前立腺癌のスクリーニング screening for prostate cancer
- 2. 前立腺特異的抗原（PSA）の測定 measurement of prostate specific antigen
- 3. 抗原提示細胞 antigen presenting cells
- 4. 胎児および新生児における免疫細胞の発達 the development of immune cells in the fetus and neonate
- 5. 成人における急性咽頭炎の評価 evaluation of acute pharyngitis in adults
English Journal
- Immunological characteristics of human umbilical cord mesenchymal stem cells and the therapeutic effects of their transplantion on hyperglycemia in diabetic rats.
- Wang H1, Qiu X1, Ni P2, Qiu X1, Lin X1, Wu W1, Xie L1, Lin L1, Min J3, Lai X1, Chen Y4, Ho G1, Ma L1.Author information 1Department of Pediatrics, Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong 515041, P.R. China.2Cancer Hospital of Shantou University Medical College, Shantou, Guangdong 515041, P.R. China.3Department of Obstetrics and Gynecology, Shenzhen Pingshan Women's And Children's Hospital, Shenzhen, Guangdong 518118, P.R. China.4Transformation Medical Center, Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong 515041, P.R. China.AbstractIslet transplantation involves the transplantation of pancreatic islets from the pancreas of a donor to another individual. It has proven to be an effective method for the treatment of type 1 diabetes. However, islet transplantation is hampered by immune rejection, as well as the shortage of donor islets. Human umbilical cord Wharton's jelly-derived mesenchymal stem cells (HUMSCs) are an ideal cell source for use in transplantation due to their biological characteristics and their use does not provoke any ethical issues. In this study, we investigated the immunological characteristics of HUMSCs and their effects on lymphocyte proliferation and the secretion of interferon (IFN)-γ, and explored whether direct cell-to-cell interactions and soluble factors, such as IFN-γ were important for balancing HUMSC-mediated immune regulation. We transplanted HUMSCs into diabetic rats to investigate whether these cells can colonize in vivo and differentiate into pancreatic β-cells, and whether the hyperglycemia of diabetic rats can be improved by transplantation. Our results revealed that HUMSCs did not stimulate the proliferation of lymphocytes and did not induce allogeneic or xenogeneic immune cell responses. qRT-PCR demonstrated that the HUMSCs produced an immunosuppressive isoform of human leukocyte antigen (HLA-I) and did not express HLA-DR. Flow cytometry revealed that the HUMSCs did not express immune response-related surface antigens such as, CD40, CD40L, CD80 and CD86. IFN-γ secretion by human peripheral blood lymphocytes was reduced when the cells were co-cultured with HUMSCs. These results suggest that HUMSCs are tolerated by the host in an allogeneic transplant. We transplanted HUMSCs into diabetic rats, and the cells survived in the liver and pancreas. Hyperglycemia of the diabetic rats was improved and the destruction of pancreatic cells was partly repaired by HUMSC transplantation. Hyperglycemic improvement may be related to the immunomodulatory effects of HUMSCs. However, the exact mechanisms involved remain to be further clarified.
- International journal of molecular medicine.Int J Mol Med.2014 Feb;33(2):263-70. doi: 10.3892/ijmm.2013.1572. Epub 2013 Nov 28.
- Islet transplantation involves the transplantation of pancreatic islets from the pancreas of a donor to another individual. It has proven to be an effective method for the treatment of type 1 diabetes. However, islet transplantation is hampered by immune rejection, as well as the shortage of donor
- PMID 24297321
- Enhanced suppression of the xenogeneic T-cell response in vitro by xenoantigen stimulated and expanded regulatory T cells.
- Jin X, Wang Y, Hawthorne WJ, Hu M, Yi S, O'Connell P.Author information 1 Center for Transplant and Renal Research, Westmead Millennium Institute, Westmead Hospital, Westmead, New South Wales, Australia. 2 Present address: Key Laboratory of Transplant Engineering and Immunology, Ministry of Health; Regenerative Medicine Research Center; West China Hospital, Sichuan University, Chengdu, Sichuan, China. 3 Transplantation Research Center, The 2nd Xiangya Hospital, Central South University, Changsha, Hunan, China. 4 Address for correspondence to: Shounan Yi, M.D., Ph.D., or Philip O'Connell, M.D., Ph.D., Centre for Transplant and Renal Research, Westmead Millennium Institute, Westmead Hospital, Westmead, New South Wales 2145, Australia.AbstractBACKGROUND: Strategies to prevent xenograft rejection while minimizing long-term immunosuppression need to be developed for successful xenotransplantaion. Polyclonally expanded human regulatory T cells (Treg) are known to suppress xenogeneic responses in vivo and in vitro. However, the risk of opportunistic infection and malignancy and the requirement for large numbers of Treg for effective suppression remain drawbacks to their clinical application. This study aimed to expand human Treg with xenoantigen stimulation and to assess their effectiveness at suppressing the xenoimmune response.
- Transplantation.Transplantation.2014 Jan 15;97(1):30-8. doi: 10.1097/TP.0b013e3182a860fa.
- BACKGROUND: Strategies to prevent xenograft rejection while minimizing long-term immunosuppression need to be developed for successful xenotransplantaion. Polyclonally expanded human regulatory T cells (Treg) are known to suppress xenogeneic responses in vivo and in vitro. However, the risk of oppor
- PMID 24092378
- Are FDA and CE sacrificing safety for a faster commercialization of xenogeneic tissue devices? Unavoidable need for legislation in decellularized tissue manufacturing.
- Naso F, Iop L, Spina M, Gerosa G.Author information Department of Cardiac, Thoracic and Vascular Sciences, University Hospital of Padova, Padova, Italy.KEYWORDS: alphaGal, biomaterials, food and drug administration, xenoantigen
- Tissue antigens.Tissue Antigens.2014 Jan 7. doi: 10.1111/tan.12275. [Epub ahead of print]
- PMID 24397352
Japanese Journal
- 異種移植臨床への研究
- 高木 弘
- 日本外科学会雑誌 99(4), 251-255, 1998-04-01
- NAID 110003936836
- ラット/マウス異種角膜移植における拒絶反応発生機序とその抑制法に関する検討
- 山上 博子,YAMAGAMI Hiroko
- 東京女子医科大学雑誌 67(11), 883-891, 1997-11-25
- … To investigate the immunological background and the immunosuppressive effect of antileukocyte function associated antigen-1 (LFA-1) monoclonal antibody (mAb) and FK506 in concordant corneal xenotransplantation, orthotopic penetrating keratoplasty was performed using Lewis rats as donors and BALB/c mice as recipients. … These results indicate that treatment with anti-LFA-1 mAb in combination with FK506 synergistically suppresses concordant corneal xenogeneic humoral and cell-mediated immune reactions. …
- NAID 110007527940
- ラット肝細胞を移植されたマウスにおける遅延型過敏応答
- 田辺 茂之 [他],田浦 保穂,古澤 修一,廣田 好和,田中 紀則,中市 統三,中間 實徳
- 日本獣医学雑誌 56(6), 1143-1148, 1994-12-15
- ラット肝細胞をマウスの背側皮下, 脾臓内および静脈内に感作されたマウスの遅延型過敏(DTH)応答が検索された. ラット肝細胞(1×10^6個)を脾臓内あるいは静脈内に前感作されたマウスは同量のラット肝細胞で皮下に感作されたマウスに比して, 有意に低いDTH応答を示した. 脾臓内感作マウスの脾細胞と皮下感作マウスの脾細胞を無処置マウスに混合移入し, DTH応答を検索したところ, 皮下感作マウスの脾細 …
- NAID 110003916177
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★リンクテーブル★
| リンク元 | 「異種抗原」「heterophile antigen」「heteroantigen」「heterologous antigen」 |
| 関連記事 | 「xenogeneic」 |
「異種抗原」
「heterophile antigen」
「heteroantigen」
「heterologous antigen」
「xenogeneic」
- 異種間の