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inflammation of the kidney and its pelvis caused by bacterial infection

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/04/18 04:20:44」(JST)

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Pyelonephritis /paɪəloʊnəˈfraɪtɪs/ (from Greek πύελο|ς pýelo|s, "basin" + νεφρ|ός nepʰrós, "kidney" + suffix -itis suggesting "inflammation") is an inflammation of the kidney tissue, calyces, and renal pelvis.^[1] It is commonly caused by bacterial infection that has spread up the urinary tract or travelled through the bloodstream to the kidneys.^[2]

A similar term is "pyelitis" which means inflammation of the pelvis and calyces.^[3]^[4] In other words, pyelitis together with nephritis is collectively known as pyelonephritis. Severe cases of pyelonephritis can lead to pyonephrosis (pus accumulation around the kidney), sepsis (a systemic inflammatory response of the body to infection), kidney failure and even death.

Pyelonephritis presents with fever, accelerated heart rate, painful urination, abdominal pain radiating to the back, nausea, and tenderness at the costovertebral angle on the affected side. Pyelonephritis that has progressed to urosepsis may be accompanied by signs of septic shock, including rapid breathing, decreased blood pressure, violent shivering, and occasionally delirium. Pyelonephritis requires antibiotic therapy, and sometimes surgical intervention such as ureteroscopy, percutaneous nephrostomy or percutaneous nephrolithotomy, as well as treatment of any underlying causes to prevent its recurrence. Xanthogranulomatous pyelonephritis is a rare form of chronic pyelonephritis in which surgical removal of the kidney is usually necessary for definitive treatment.

Signs and symptoms

Signs and symptoms of acute pyelonephritis generally develop rapidly over a few hours or a day. It can cause high fever, pain on passing urine, and abdominal pain that radiates along the flank towards the back. There is often associated vomiting.^[5]

Chronic pyelonephritis causes persistent flank or abdominal pain, signs of infection (fever, unintentional weight loss, malaise, decreased appetite), lower urinary tract symptoms and blood in the urine.^[6] Chronic pyelonephritis can in addition cause fever of unknown origin. Furthermore, inflammation-related proteins can accumulate in organs and cause the condition AA amyloidosis.^[7]

Physical examination may reveal fever and tenderness at the costovertebral angle on the affected side.^[8]

Causes

Most cases of "community-acquired" pyelonephritis are due to bowel organisms that enter the urinary tract. Common organisms are E. coli (70–80%) and Enterococcus faecalis. Hospital-acquired infections may be due to coliform bacteria and enterococci, as well as other organisms uncommon in the community (e.g., Pseudomonas aeruginosa and various species of Klebsiella). Most cases of pyelonephritis start off as lower urinary tract infections, mainly cystitis and prostatitis.^[5] E. coli can invade the superficial umbrella cells of the bladder to form intracellular bacterial communities (IBCs), which can mature into biofilms. These biofilm-producing E. coli are resistant to antibiotic therapy and immune system responses, and present a possible explanation for recurrent urinary tract infections, including pyelonephritis.^[9] Risk is increased in the following situations:^[5]^[10]

Mechanical: any structural abnormalities in the urinary tract, vesicoureteral reflux (urine from the bladder flowing back into the ureter), kidney stones, urinary tract catheterization, ureteral stents or drainage procedures (e.g., nephrostomy), pregnancy, neurogenic bladder (e.g., due to spinal cord damage, spina bifida or multiple sclerosis) and prostate disease (e.g., benign prostatic hyperplasia) in men
Constitutional: diabetes mellitus, immunocompromised states
Behavioral: change in sexual partner within the last year, spermicide use
Positive family history (close family members with frequent urinary tract infections)

Diagnosis

Laboratory examination

Analysis of the urine may show signs of urinary tract infection. Specifically, the presence of nitrite and white blood cells on a urine test strip in patients with typical symptoms are sufficient for the diagnosis of pyelonephritis, and are an indication for empirical treatment. Blood tests such as a complete blood count may show neutrophilia. Microbiological culture of the urine, with or without blood cultures and antibiotic sensitivity testing are useful for establishing a formal diagnosis,^[5] and are considered mandatory.^[11]

Imaging studies

If a kidney stone is suspected (e.g. on the basis of characteristic colicky pain or the presence of a disproportionate amount of blood in the urine), a kidneys, ureters, and bladder x-ray (KUB film) may assist in identifying radioopaque stones.^[5] Where available, a noncontrast helical CT scan with 5 millimeter sections is the diagnostic modality of choice in the radiographic evaluation of suspected nephrolithiasis.^[12]^[13]^[14] All stones are detectable on CT scans except very rare stones composed of certain drug residues in the urine.^[15] In patients with recurrent ascending urinary tract infections, it may be necessary to exclude an anatomical abnormality, such as vesicoureteral reflux or polycystic kidney disease. Investigations used in this setting include ultrasonography of the kidneys or voiding cystourethrography.^[5] CT scan or abdominal ultrasonography is useful in the diagnosis of xanthogranulomatous pyelonephritis; serial imaging may be useful for differentiating this condition from kidney cancer.^[6]

A DMSA scan is a radionuclide scan that uses dimercaptosuccinic acid in assessing the kidney morphology. It is now the most reliable test for the diagnosis of acute pyelonephritis.^[16]

Classification

Acute pyelonephritis

Acute pyelonephritis is an exudative purulent localized inflammation of the renal pelvis (collecting system) and kidney. The kidney parenchyma presents in the interstitium abscesses (suppurative necrosis), consisting in purulent exudate (pus): neutrophils, fibrin, cell debris and central germ colonies (hematoxylinophils). Tubules are damaged by exudate and may contain neutrophil casts. In the early stages, the glomerulus and vessels are normal. Gross pathology often reveals pathognomonic radiations of bleeding and suppuration through the renal pelvis to the renal cortex.^{[citation needed]}

Chronic pyelonephritis

Chronic pyelonephritis implies recurrent kidney infections, and can result in scarring of the renal parenchyma and impaired function, especially in the setting of obstruction. A perinephric abscess (infection around the kidney) and/or pyonephrosis may develop in severe cases of pyelonephritis.^[17]

Xanthogranulomatous pyelonephritis

Xanthogranulomatous pyelonephritis is an unusual form of chronic pyelonephritis characterized by granulomatous abscess formation, severe kidney destruction, and a clinical picture that may resemble renal cell carcinoma and other inflammatory kidney parenchymal diseases. Most affected individuals present with recurrent fevers and urosepsis, anemia, and a painful kidney mass. Other common manifestations include kidney stones and loss of function of the affected kidney. Bacterial cultures of kidney tissue are almost always positive.^[18] Microscopically, there are granulomas and lipid-laden macrophages (hence the term xantho-, which means yellow in ancient Greek). It is found in roughly 20% of specimens from surgically managed cases of pyelonephritis.^[6]

Management

In patients suspected of having pyelonephritis, a urine culture and antibiotic sensitivity test is performed, and initial therapy is tailored on the basis of the infecting organism. As most cases of pyelonephritis are due to bacterial infections, antibiotics are the mainstay of treatment. The choice of antibiotic depends on the species and antibiotic sensitivity profile of the infecting organism, and may include fluoroquinolones, cephalosporins, aminoglycosides, or trimethoprim/sulfamethoxazole, either alone or in combination.^[11]

In people who do not require hospitalization and live in an area where there is a low prevalence of antibiotic-resistant bacteria, an oral fluoroquinolone such as ciprofloxacin or levofloxacin is an appropriate initial choice for therapy. In areas where there is a higher prevalence of fluoroquinolone resistance, it is useful to initiate treatment with a single intravenous dose of a long-acting antibiotic such as ceftriaxone or an aminoglycoside, and then continuing treatment with an oral fluoroquinolone. Oral trimethoprim/sulfamethoxazole is an appropriate choice for therapy if the uropathogen is known to be susceptible. If trimethoprim/sulfamethoxazole is used when the susceptibility is not known, it is useful to initiate treatment with a single intravenous dose of a long-acting antibiotic such as ceftriaxone or an aminoglycoside. Oral beta-lactam antibiotics are less effective than other available agents for treatment of pyelonephritis.^[11]

People with acute pyelonephritis that is accompanied by high fever and leukocytosis are typically admitted to the hospital for intravenous hydration and intravenous antibiotic treatment. Treatment is typically initiated with an intravenous fluoroquinolone, an aminoglycoside, an extended-spectrum penicillin or cephalosporin, or a carbapenem. Combination antibiotic therapy is often used in such situations. The treatment regimen is selected based on local resistance data and the susceptibility profile of the specific infecting organism(s).^[11]

During the course of antibiotic treatment, serial white blood cell count and temperature are closely monitored. Typically, the intravenous antibiotics are continued until the patient is afebrile for at least 24 to 48 hours, then equivalent oral antibiotic agents can be given for a total of 2–week duration of treatment.^[19] Intravenous fluids may be administered to compensate for the reduced oral intake, insensible losses (due to the raised temperature) and vasodilation and to optimize urine output. Percutaneous nephrostomy or ureteral stent placement may be indicated to relieve obstruction caused by a stone. Children with acute pyelonephritis can be treated effectively with oral antibiotics (cefixime, ceftibuten and amoxicillin/clavulanic acid) or with short courses (2 to 4 days) of intravenous therapy followed by oral therapy.^[20] If intravenous therapy is chosen, single daily dosing with aminoglycosides is safe and effective.^[20]

Treatment of xanthogranulomatous pyelonephritis involves antibiotics as well as surgery. Removal of the kidney is the best surgical treatment in the overwhelming majority of cases, although polar resection (partial nephrectomy) has been effective for some people with localized disease.^[6]^[21] Watchful waiting with serial imaging may be appropriate in rare circumstances.^[22]

Prevention

In people who experience recurrent urinary tract infections, additional investigations may identify an underlying abnormality. Occasionally, surgical intervention is necessary to reduce the likelihood of recurrence. If no abnormality is identified, some studies suggest long-term preventive (prophylactic) treatment with antibiotics, either daily or after sexual activity.^[23] In children at risk for recurrent urinary tract infections, meta-analysis of the existing literature indicates that not enough studies have been performed to conclude prescription of long-term antibiotics have a net positive benefit.^[24] Ingestion of cranberry juice has been studied as a prophylactic measure; many studies suggest a benefit.^[25]^[26]^[27] Increasing fluid intake, consuming cranberry juice, blueberry juice, and fermented milk products containing probiotic bacteria have all been shown to inhibit adherence of bacteria to the epithelial cell of the urinary tract, and may reduce the recurrence rate of urinary tract infections.^[25]

Epidemiology

The incidence of pyelonephritis is roughly 12–13 cases annually per 10,000 population in women receiving outpatient treatment and 3–4 cases requiring admission. In men, 2–3 cases per 10,000 are treated as outpatients and 1– cases/10,000 require admission.^[28] Young women are most often affected, probably reflecting sexual activity in that age group. Infants and the elderly are also at increased risk, reflecting anatomical changes and hormonal status.^[28] Xanthogranulomatous pyelonephritis is most common in middle-aged women.^[18] It can present somewhat differently in children, in whom it may be mistaken for Wilms' tumor.^[29]

References

^ medilexicon.com
^ merckmanuals.com
^ medilexicon.com
^ Using Medical Terminology: A Practical Approach 2006 p.723
^ ^a ^b ^c ^d ^e ^f Ramakrishnan, K; Scheid, DC (2005). "Diagnosis and management of acute pyelonephritis in adults". American Family Physician 71 (5): 933–42. PMID 15768623.
^ ^a ^b ^c ^d Korkes, F; Favoretto RL; Bróglio M; Silva CA; Castro MG; Perez MD (2008). "Xanthogranulomatous pyelonephritis: clinical experience with 41 cases". Urology 71 (2): 178–80. doi:10.1016/j.urology.2007.09.026. PMID 18308077.
^ Herrera, GA; Picken, MM (2007). "Chapter 19: Renal Diseases". In Jennette, JC; Olson, JL; Schwartz, MM; et al. Heptinstall's Pathology of the Kidney 2 (6th ed.). Philadelphia: Lippincott Williams & Wilkins. pp. 853–910. ISBN 978-0-7817-4750-9.
^ Weiss, M; Liapis, H; Tomaszewski, JE; Arend, LJ (2007). "Chapter 22: Pyelonephritis and other infections, reflux nephropathy, hydronephrosis, and nephrolithiasis". In Jennette, JC; Olson, JL; Schwartz, MM; et al. Heptinstall's Pathology of the Kidney 2 (6th ed.). Philadelphia: Lippincott Williams & Wilkins. pp. 991–1082. ISBN 978-0-7817-4750-9.
^ Hultgren, SJ (2011). "Pathogenic Cascade of E. coli UTI". UTI Pathogenesis. St. Louis, Missouri: Molecular Microbiology and Microbial Pathogenesis Program, Washington University. Retrieved 2011-06-05.
^ Scholes, D; Hooton TM; Roberts PL; Gupta K; Stapleton AE; Stamm WE (2005). "Risk factors associated with acute pyelonephritis in healthy women" (PDF). Annals of Internal Medicine 142 (1): 20–7. doi:10.7326/0003-4819-142-1-200501040-00008. PMID 15630106.
^ ^a ^b ^c ^d Gupta, K; Hooton TM; et al. (2011). "International Clinical Practice Guidelines for the Treatment of Acute Uncomplicated Cystitis and Pyelonephritis in Women: A 2010 Update by the Infectious Diseases Society of America and the European Society for Microbiology and Infectious Diseases" (PDF). Clinical Infectious Diseases 52 (5): e103–20. doi:10.1093/cid/ciq257. PMID 21292654.
^ Pearle, MS; Calhoun, EA; Curhan, GC (2007). "Chapter 8: Urolithiasis". In Litwin, MS; Saigal, CS. Urologic Diseases in America (NIH Publication No. 07–5512) (PDF). Bethesda, Maryland: US Department of Health and Human Services, Public Health Service, National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases. pp. 283–319.
^ Smith, RC; Varanelli, M (2000). "Diagnosis and Management of Acute Ureterolithiasis: CT Is Truth" (PDF). American Journal of Roentgenology 175 (1): 3–6. doi:10.2214/ajr.175.1.1750003. PMID 10882237.
^ Fang, LST (2009). "Chapter 135: Approach to the Paient with Nephrolithiasis". In Goroll, AH; Mulley, AG. Primary care medicine: office evaluation and management of the adult patient (6th ed.). Philadelphia: Lippincott Williams & Wilkins. pp. 962–7. ISBN 978-0-7817-7513-7.
^ Pietrow, PK; Karellas ME (2006). "Medical Management of Common Urinary Calculi" (PDF). American Family Physician 74 (1): 86–94. PMID 16848382.
^ Goldraich NP, Goldraich IH (April 1995). "Update on dimercaptosuccinic acid renal scanning in children with urinary tract infection". Pediatr. Nephrol. 9: 221–6; discussion 227. doi:10.1007/bf00860755. PMID 7794724.
^ Griebling, TL (2007). "Chapter 18: Urinary Tract Infection in Women". In Litwin, MS; Saigal, CS. Urologic Diseases in America (NIH Publication No. 07–5512) (PDF). Bethesda, Maryland: US Department of Health and Human Services, Public Health Service, National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases. pp. 589–619.
^ ^a ^b Malek, RS; Elder, JS (1978). "Xanthogranulomatous pyelonephritis: a critical analysis of 26 cases and of the literature". Journal of Urology 119 (5): 589–93. PMID 660725.
^ Cabellon, MCL (2005). "Chapter 8: Urinary Tract Infections". In Starlin, R. The Washington Manual: Infectious Diseases Subspecialty Consult (1st ed.). Philadelphia: Lippincott Williams & Wilkins. pp. 95–108. ISBN 978-0-7817-4373-0.
^ ^a ^b Strohmeier Y, Hodson EM, Willis NS, Webster AC, Craig JC (July 2014). "Antibiotics for acute pyelonephritis in children". Cochrane Database of Systematic Reviews 7: CD003772. doi:10.1002/14651858.CD003772.pub4. PMID 25066627.
^ Rosi, P; Selli C; Carini M; Rosi MF; Mottola A (1986). "Xanthogranulomatous pyelonephritis: clinical experience with 62 cases". European Urology 12 (2): 96–100. PMID 3956552.
^ Lebret, T; Poulain JE; Molinie V; Herve JM; Denoux Y; Guth A; Scherrer A; Botto H (2007). "Percutaneous core biopsy for renal masses: indications, accuracy and results". The Journal of Urology 178 (4 Pt 1): 1184–8. doi:10.1016/j.juro.2007.05.155. PMID 17698122.
^ Schooff, M; Hill, K (2005). "Antibiotics for recurrent urinary tract infections". American Family Physician 71 (7): 1301–2. PMID 15832532.
^ Williams, GJ; Craig, JC (2011). Williams, Gabrielle, ed. "Long-term antibiotics for preventing recurrent urinary tract infection in children". Cochrane Database of Systematic Reviews 2011 (3): CD001534. doi:10.1002/14651858.CD001534.pub3. PMID 21412872.
^ ^a ^b Wilkens, KG; Juneja, V (2007). "Chapter 39: Medical Nutrition Therapy for Renal Disorders". In Mahan, LK; Escott-Stump. Krause's food & nutrition therapy (12th ed.). Philadelphia: W.B. Saunders. pp. 921–58. ISBN 978-1-4160-3401-8.
^ Raz, R; Chazan B; Dan M (2004). "Cranberry juice and urinary tract infection" (PDF). Clinical Infectious Diseases 38 (10): 1413–9. doi:10.1086/386328. PMID 15156480.
^ Wang CH, Fang CC, Chen NC, et al. (2012). "Cranberry-containing products for prevention of urinary tract infections in susceptible populations". Arch Intern Med 172 (13): 988–96. doi:10.1001/archinternmed.2012.3004. PMID 22777630.
^ ^a ^b Czaja, CA; Scholes D; Hooton TM; Stamm WE (2007). "Population-based epidemiologic analysis of acute pyelonephritis" (PDF). Clin Infect Dis 45 (3): 273–80. doi:10.1086/519268. PMID 17599303.
^ Goodman, TR; McHugh K; Lindsell DR (1998). "Paediatric xanthogranulomatous pyelonephritis". International Journal of Clinical Practice 52 (1): 43–5. PMID 9536568.

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1. 黄色肉芽腫性腎盂腎炎 xanthogranulomatous pyelonephritis
2. 腎の小腫瘤の診断的アプローチ、鑑別診断、および治療 diagnostic approach differential diagnosis and treatment of a small renal mass
3. 急性複雑性膀胱炎および腎盂腎炎 acute complicated cystitis and pyelonephritis
4. 小児における腎結石症の疫学および危険因子 epidemiology of and risk factors for nephrolithiasis in children
5. 黄色肉芽腫性胆嚢炎 xanthogranulomatous cholecystitis

English Journal

[Xanthogranulomatous pyelonephritis with cutaneous fistula and a right flank mass].

Moreno-Cuerda VJ1, Meizoso-Latova T2, Morales-Conejo M3, Ruiz-Galiana J4.
Medicina clínica.Med Clin (Barc).2015 Jun 8;144(11):e21. doi: 10.1016/j.medcli.2014.12.001. Epub 2015 Jan 8.
PMID 25577579

Xanthogranulomatous pyelonephritis with colesional actinomycosis in a 63-year-old man.

Gulwani HV1.
Indian journal of urology : IJU : journal of the Urological Society of India.Indian J Urol.2015 Apr-Jun;31(2):144-5. doi: 10.4103/0970-1591.152925.
Xanthogranulomatous pyelonephritis is an uncommon chronic destructive granulomatous disease of the kidney. A rare case of xanthogranulomatous pyelonephritis with extrarenal extension that had coexistence of renal actinomycosis is described in this article.
PMID 25878419

Japanese Journal

下行結腸に炎症の波及した黄色肉芽腫性腎盂腎炎の1例

黒田悠太,柴崎智宏,中野裕子 [他]
山形県立病院医学雑誌 44(1), 39-42, 2010-01
NAID 40017120227

黄色肉芽腫性腎盂腎炎と鑑別が困難であった腎浸潤性移行上皮癌の1例

大関孝之,森康範,加藤良成 [他]
泌尿器科紀要 56(10), 573-576, 2010-10
… The patient was scheduled for surgery, which was postponed when pre-operative CT indicated a reduction in the tumor size, leading to a subsequent diagnosis of xanthogranulomatous pyelonephritis. …
NAID 120002576702

Related Pictures

★リンクテーブル★

リンク元	「黄色肉芽腫性腎盂腎炎」

「黄色肉芽腫性腎盂腎炎」

Pyelonephritis
	CD68 immunostaining on this photomicrograph shows macrophages and giant cells in a case of xanthogranulomatous pyelonephritis
Classification and external resources
Specialty	Urology Nephrology
ICD-10	N10-N12, N13.6, N20.9
ICD-9-CM	590.0, 590.1, 590.3, 590.8, 590.81
DiseasesDB	11052 29255 31522
MedlinePlus	001274
eMedicine	ped/1959
Patient UK	Pyelonephritis
MeSH	D011704
	[edit on Wikidata]

　　[★]

英: xanthogranulomatous pyelonephritis

[1] xicon.com

[2] rckmanuals.com

[3] xicon.com

[4] Using Medical Terminology: A Practical Approach 2006 p.723

[Ramakrishnan2005-5] ^ ^a ^b ^c ^d ^e ^f Ramakrishnan, K; Scheid, DC (2005). "Diagnosis and management of acute pyelonephritis in adults". American Family Physician 71 (5): 933–42. PMID 15768623.

[Korkes2008-6] Korkes, F; Favoretto RL; Bróglio M; Silva CA; Castro MG; Perez MD (2008). "Xanthogranulomatous pyelonephritis: clinical experience with 41 cases". Urology 71 (2): 178–80. doi:10.1016/j.urology.2007.09.026. PMID 18308077.

[Herrera2007-7] Herrera, GA; Picken, MM (2007). "Chapter 19: Renal Diseases". In Jennette, JC; Olson, JL; Schwartz, MM; et al. Heptinstall's Pathology of the Kidney 2 (6th ed.). Philadelphia: Lippincott Williams & Wilkins. pp. 853–910. ISBN 978-0-7817-4750-9.

[Weiss2007-8] Weiss, M; Liapis, H; Tomaszewski, JE; Arend, LJ (2007). "Chapter 22: Pyelonephritis and other infections, reflux nephropathy, hydronephrosis, and nephrolithiasis". In Jennette, JC; Olson, JL; Schwartz, MM; et al. Heptinstall's Pathology of the Kidney 2 (6th ed.). Philadelphia: Lippincott Williams & Wilkins. pp. 991–1082. ISBN 978-0-7817-4750-9.

[Hultgren2011-9] Hultgren, SJ (2011). "Pathogenic Cascade of E. coli UTI". UTI Pathogenesis. St. Louis, Missouri: Molecular Microbiology and Microbial Pathogenesis Program, Washington University. Retrieved 2011-06-05.

[Scholes2005-10] Scholes, D; Hooton TM; Roberts PL; Gupta K; Stapleton AE; Stamm WE (2005). "Risk factors associated with acute pyelonephritis in healthy women" (PDF). Annals of Internal Medicine 142 (1): 20–7. doi:10.7326/0003-4819-142-1-200501040-00008. PMID 15630106.

[Gupta2011-11] Gupta, K; Hooton TM; et al. (2011). "International Clinical Practice Guidelines for the Treatment of Acute Uncomplicated Cystitis and Pyelonephritis in Women: A 2010 Update by the Infectious Diseases Society of America and the European Society for Microbiology and Infectious Diseases" (PDF). Clinical Infectious Diseases 52 (5): e103–20. doi:10.1093/cid/ciq257. PMID 21292654.

[Pearle2007-12] Pearle, MS; Calhoun, EA; Curhan, GC (2007). "Chapter 8: Urolithiasis". In Litwin, MS; Saigal, CS. Urologic Diseases in America (NIH Publication No. 07–5512) (PDF). Bethesda, Maryland: US Department of Health and Human Services, Public Health Service, National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases. pp. 283–319.

[SmithCentennial2000-13] Smith, RC; Varanelli, M (2000). "Diagnosis and Management of Acute Ureterolithiasis: CT Is Truth" (PDF). American Journal of Roentgenology 175 (1): 3–6. doi:10.2214/ajr.175.1.1750003. PMID 10882237.

[Fang2009-14] Fang, LST (2009). "Chapter 135: Approach to the Paient with Nephrolithiasis". In Goroll, AH; Mulley, AG. Primary care medicine: office evaluation and management of the adult patient (6th ed.). Philadelphia: Lippincott Williams & Wilkins. pp. 962–7. ISBN 978-0-7817-7513-7.

[Pietrow2006-15] Pietrow, PK; Karellas ME (2006). "Medical Management of Common Urinary Calculi" (PDF). American Family Physician 74 (1): 86–94. PMID 16848382.

[16] Goldraich NP, Goldraich IH (April 1995). "Update on dimercaptosuccinic acid renal scanning in children with urinary tract infection". Pediatr. Nephrol. 9: 221–6; discussion 227. doi:10.1007/bf00860755. PMID 7794724.

[Griebling2007-17] Griebling, TL (2007). "Chapter 18: Urinary Tract Infection in Women". In Litwin, MS; Saigal, CS. Urologic Diseases in America (NIH Publication No. 07–5512) (PDF). Bethesda, Maryland: US Department of Health and Human Services, Public Health Service, National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases. pp. 589–619.

[Malek1978-18] Malek, RS; Elder, JS (1978). "Xanthogranulomatous pyelonephritis: a critical analysis of 26 cases and of the literature". Journal of Urology 119 (5): 589–93. PMID 660725.

[Starlin2005-19] Cabellon, MCL (2005). "Chapter 8: Urinary Tract Infections". In Starlin, R. The Washington Manual: Infectious Diseases Subspecialty Consult (1st ed.). Philadelphia: Lippincott Williams & Wilkins. pp. 95–108. ISBN 978-0-7817-4373-0.

[Strohmeier2014-20] Strohmeier Y, Hodson EM, Willis NS, Webster AC, Craig JC (July 2014). "Antibiotics for acute pyelonephritis in children". Cochrane Database of Systematic Reviews 7: CD003772. doi:10.1002/14651858.CD003772.pub4. PMID 25066627.

[Rosi1986-21] Rosi, P; Selli C; Carini M; Rosi MF; Mottola A (1986). "Xanthogranulomatous pyelonephritis: clinical experience with 62 cases". European Urology 12 (2): 96–100. PMID 3956552.

[Lebret2007-22] Lebret, T; Poulain JE; Molinie V; Herve JM; Denoux Y; Guth A; Scherrer A; Botto H (2007). "Percutaneous core biopsy for renal masses: indications, accuracy and results". The Journal of Urology 178 (4 Pt 1): 1184–8. doi:10.1016/j.juro.2007.05.155. PMID 17698122.

[Schooff2005-23] Schooff, M; Hill, K (2005). "Antibiotics for recurrent urinary tract infections". American Family Physician 71 (7): 1301–2. PMID 15832532.

[Williams2011-24] Williams, GJ; Craig, JC (2011). Williams, Gabrielle, ed. "Long-term antibiotics for preventing recurrent urinary tract infection in children". Cochrane Database of Systematic Reviews 2011 (3): CD001534. doi:10.1002/14651858.CD001534.pub3. PMID 21412872.

[Mahan2007-25] Wilkens, KG; Juneja, V (2007). "Chapter 39: Medical Nutrition Therapy for Renal Disorders". In Mahan, LK; Escott-Stump. Krause's food & nutrition therapy (12th ed.). Philadelphia: W.B. Saunders. pp. 921–58. ISBN 978-1-4160-3401-8.

[Raz2004-26] Raz, R; Chazan B; Dan M (2004). "Cranberry juice and urinary tract infection" (PDF). Clinical Infectious Diseases 38 (10): 1413–9. doi:10.1086/386328. PMID 15156480.

[Wang2012-27] Wang CH, Fang CC, Chen NC, et al. (2012). "Cranberry-containing products for prevention of urinary tract infections in susceptible populations". Arch Intern Med 172 (13): 988–96. doi:10.1001/archinternmed.2012.3004. PMID 22777630.

[Czaja2007-28] Czaja, CA; Scholes D; Hooton TM; Stamm WE (2007). "Population-based epidemiologic analysis of acute pyelonephritis" (PDF). Clin Infect Dis 45 (3): 273–80. doi:10.1086/519268. PMID 17599303.

[Goodman1998-29] Goodman, TR; McHugh K; Lindsell DR (1998). "Paediatric xanthogranulomatous pyelonephritis". International Journal of Clinical Practice 52 (1): 43–5. PMID 9536568.

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xanthogranulomatous pyelonephritis