vumon

Teniposide
Systematic (IUPAC) name
	(5R,5aR,8aR,9S)-5,8,8a,9-Tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-9-({4,6-O-[(R)-2-thienylmethylene]-β-D-glucopyranosyl}oxy)furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one
Clinical data
AHFS/Drugs.com	monograph
MedlinePlus	a692045
Pregnancy cat.	D (AU) D (US)
Legal status	℞-only (US)
Routes	Intravenous
Pharmacokinetic data
Bioavailability	n/a
Protein binding	>99%
Metabolism	Hepatic (CYP2C19-mediated)
Half-life	5 hours
Excretion	Renal and fecal
Identifiers
CAS number	29767-20-2
ATC code	L01CB02
PubChem	CID 34698
DrugBank	DB00444
ChemSpider	31930
UNII	957E6438QA
KEGG	D02698
ChEBI	CHEBI:75988
ChEMBL	CHEMBL1200536
Chemical data
Formula	C32H32O13S
Mol. mass	656.655 g/mol
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Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/07/24 23:46:38」(JST)

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Teniposide (Vumon, VM-26) is a chemotherapeutic medication^[1] mainly used in the treatment of childhood acute lymphocytic leukemia (ALL). It is in a class of drugs known as podophyllotoxin derivatives and slows the growth of cancer cells in the body.

Mechanism of action

Teniposide causes dose-dependent single- and double-stranded breaks in DNA and DNA-protein cross-links. The mechanism of action appears to be related to the inhibition of type II topoisomerase activity since teniposide does not intercalate into DNA or bind strongly to DNA. The cytotoxic effects of teniposide are related to the relative number of double-stranded DNA breaks produced in cells, which are a reflection of the stabilization of a topoisomerase II-DNA intermediate.

Administration

The medication is injected though a vein and burns if it leaks under the skin. It is sometimes used in combination with other anticancer drugs.

Side-effects

Teniposide, when used with other chemotherapeutic agents for the treatment of ALL, results in severe myelosuppression. Other common side effects include gastrointestinal toxicity, hypersensitivity reactions, and alopecia.

References

^ Cragg, Gordon M.; Newman, David J. (2005). "Plants as a source of anti-cancer agents". Journal of Ethnopharmacology 100 (1–2): 72–9. doi:10.1016/j.jep.2005.05.011. PMID 16009521.

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UpToDate Contents

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English Journal

Podophyllotoxin derivatives: a patent review (2012 - 2014).

Kamal A1, Ali Hussaini SM, Rahim A, Riyaz S.
Expert opinion on therapeutic patents.Expert Opin Ther Pat.2015 Sep;25(9):1025-34. doi: 10.1517/13543776.2015.1051727. Epub 2015 Jun 2.
INTRODUCTION: Podophyllotoxin (PPT) is a naturally occurring antimitotic agent and an interesting lead in the development of anticancer agents. Its optimization led to the development of etoposide and teniposide used in combination chemotherapy with other anticancer drugs; unlike PPT these drugs act
PMID 26027947

Expression of OATP2B1 as determinant of drug effects in the microcompartment of the coronary artery.

Hussner J1, Begunk R2, Boettcher K2, Gliesche DG1, Prestin K1, Meyer Zu Schwabedissen HE3.
Vascular pharmacology.Vascul Pharmacol.2015 Sep;72:25-34. doi: 10.1016/j.vph.2015.06.006. Epub 2015 Jun 16.
Clinical success of coronary drug-eluting stents (DES) is hampered by simultaneous reduction of smooth muscle cell (HCASMC) and endothelial cell proliferation due to unspecific cytotoxicity of currently used compounds. Previous in vitro data showing SMC-specific inhibition of proliferation suggested
PMID 26091578

Endophytic Fungus from Sinopodophyllum emodi (Wall.) Ying that Produces Podophyllotoxin.

Liang Z1, Zhang J1, Zhang X1, Li J1, Zhang X1, Zhao C2.
Journal of chromatographic science.J Chromatogr Sci.2015 Aug 25. pii: bmv124. [Epub ahead of print]
The aryltetralin lactone podophyllotoxin, which exhibits pronounced antineoplastic activity, is used as the precursor of the following three clinical anticancer drugs: Etoposide™, Etopophos™ and Teniposide™. The natural occurrence of this arylnaphthalene lignan is scarce and unable to meet the
PMID 26306574

Related Pictures

Tenipósido - EcuRed VUMON (E.R. Squibb & Sons, L.L.C.): FDA Package Insert, Page 4 Vumon - patient information, description, dosage and directions. CAS No.29767-20-2,Teniposide Suppliers,MSDS download VUMON é indicado para o tratamento das seguintes condições, normalmente associado VUMON® (teniposide injection) VUMON - Galenox.com ¡Tu colega siempre en línea! teniposide intravenous : Uses, Side Effects, Interactions, Pictures, Warnings & Dosing

[1] Cragg, Gordon M.; Newman, David J. (2005). "Plants as a source of anti-cancer agents". Journal of Ethnopharmacology 100 (1–2): 72–9. doi:10.1016/j.jep.2005.05.011. PMID 16009521.

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