- 同
- tenoposide
- 関
- teniposide
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/07/24 23:46:38」(JST)
[Wiki en表示]
Teniposide
|
Systematic (IUPAC) name |
(5R,5aR,8aR,9S)-5,8,8a,9-Tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-9-({4,6-O-[(R)-2-thienylmethylene]-β-D-glucopyranosyl}oxy)furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one |
Clinical data |
AHFS/Drugs.com |
monograph |
MedlinePlus |
a692045 |
Pregnancy cat. |
D (AU) D (US) |
Legal status |
℞-only (US) |
Routes |
Intravenous |
Pharmacokinetic data |
Bioavailability |
n/a |
Protein binding |
>99% |
Metabolism |
Hepatic (CYP2C19-mediated) |
Half-life |
5 hours |
Excretion |
Renal and fecal |
Identifiers |
CAS number |
29767-20-2 Y |
ATC code |
L01CB02 |
PubChem |
CID 34698 |
DrugBank |
DB00444 |
ChemSpider |
31930 N |
UNII |
957E6438QA N |
KEGG |
D02698 Y |
ChEBI |
CHEBI:75988 N |
ChEMBL |
CHEMBL1200536 N |
Chemical data |
Formula |
C32H32O13S |
Mol. mass |
656.655 g/mol |
N (what is this?) (verify) |
Teniposide (Vumon, VM-26) is a chemotherapeutic medication[1] mainly used in the treatment of childhood acute lymphocytic leukemia (ALL). It is in a class of drugs known as podophyllotoxin derivatives and slows the growth of cancer cells in the body.
Contents
- 1 Mechanism of action
- 2 Administration
- 3 Side-effects
- 4 References
Mechanism of action
Teniposide causes dose-dependent single- and double-stranded breaks in DNA and DNA-protein cross-links. The mechanism of action appears to be related to the inhibition of type II topoisomerase activity since teniposide does not intercalate into DNA or bind strongly to DNA. The cytotoxic effects of teniposide are related to the relative number of double-stranded DNA breaks produced in cells, which are a reflection of the stabilization of a topoisomerase II-DNA intermediate.
Administration
The medication is injected though a vein and burns if it leaks under the skin. It is sometimes used in combination with other anticancer drugs.
Side-effects
Teniposide, when used with other chemotherapeutic agents for the treatment of ALL, results in severe myelosuppression. Other common side effects include gastrointestinal toxicity, hypersensitivity reactions, and alopecia.
References
- ^ Cragg, Gordon M.; Newman, David J. (2005). "Plants as a source of anti-cancer agents". Journal of Ethnopharmacology 100 (1–2): 72–9. doi:10.1016/j.jep.2005.05.011. PMID 16009521.
UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
English Journal
- Podophyllotoxin derivatives: a patent review (2012 - 2014).
- Kamal A1, Ali Hussaini SM, Rahim A, Riyaz S.
- Expert opinion on therapeutic patents.Expert Opin Ther Pat.2015 Sep;25(9):1025-34. doi: 10.1517/13543776.2015.1051727. Epub 2015 Jun 2.
- INTRODUCTION: Podophyllotoxin (PPT) is a naturally occurring antimitotic agent and an interesting lead in the development of anticancer agents. Its optimization led to the development of etoposide and teniposide used in combination chemotherapy with other anticancer drugs; unlike PPT these drugs act
- PMID 26027947
- Expression of OATP2B1 as determinant of drug effects in the microcompartment of the coronary artery.
- Hussner J1, Begunk R2, Boettcher K2, Gliesche DG1, Prestin K1, Meyer Zu Schwabedissen HE3.
- Vascular pharmacology.Vascul Pharmacol.2015 Sep;72:25-34. doi: 10.1016/j.vph.2015.06.006. Epub 2015 Jun 16.
- Clinical success of coronary drug-eluting stents (DES) is hampered by simultaneous reduction of smooth muscle cell (HCASMC) and endothelial cell proliferation due to unspecific cytotoxicity of currently used compounds. Previous in vitro data showing SMC-specific inhibition of proliferation suggested
- PMID 26091578
- Endophytic Fungus from Sinopodophyllum emodi (Wall.) Ying that Produces Podophyllotoxin.
- Liang Z1, Zhang J1, Zhang X1, Li J1, Zhang X1, Zhao C2.
- Journal of chromatographic science.J Chromatogr Sci.2015 Aug 25. pii: bmv124. [Epub ahead of print]
- The aryltetralin lactone podophyllotoxin, which exhibits pronounced antineoplastic activity, is used as the precursor of the following three clinical anticancer drugs: Etoposide™, Etopophos™ and Teniposide™. The natural occurrence of this arylnaphthalene lignan is scarce and unable to meet the
- PMID 26306574
Related Links
- 1 VUMON® (teniposide injection) WARNING VUMON (teniposide injection) is a cytotoxic drug which should be administered under the supervision of a qualified physician experienced in the use of cancer chemotherapeutic agents.
- Vumon - Get up-to-date information on Vumon side effects, uses, dosage, overdose, pregnancy, alcohol and more. Learn more about Vumon ... Serious side effects have been reported with Vumon including the following: Vumon can ...
Related Pictures
![Tenipósido - EcuRed](https://1mg.info/0/n/n/0510.jpg)
![VUMON (E.R. Squibb & Sons, L.L.C.): FDA Package Insert, Page 4](https://1mg.info/0/n/n/0511.jpg)
![Vumon - patient information, description, dosage and directions.](https://1mg.info/0/n/n/0512.jpg)
![CAS No.29767-20-2,Teniposide Suppliers,MSDS download](https://1mg.info/0/n/n/0513.jpg)
![VUMON é indicado para o tratamento das seguintes condições, normalmente associado](https://1mg.info/0/n/n/0514.jpg)
![VUMON® (teniposide injection)](https://1mg.info/0/n/n/0515.jpg)
![VUMON - Galenox.com ¡Tu colega siempre en línea!](https://1mg.info/0/n/n/0516.jpg)