ウイルス性筋炎
WordNet
- relating to or caused by a virus; "viral infection"
- inflammation of muscle tissue
PrepTutorEJDIC
- ウィルスの;ウィルスが原因の
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English Journal
- Distinct differences in clinical manifestation and viral laboratory parameters between children and adults with influenza A(H1N1)pdm09 infection-A retrospective comparative analysis.
- Redlberger-Fritz M1, Hirk S, Buchinger D, Haberl R, Hell M, Perkmann-Nagele N, Kundi M, Popow-Kraupp T.Author information 1Department of Virology, Medical University Vienna, Vienna, Austria.AbstractDuring the influenza pandemic 2009 children and adults differed in the clinical course of the influenza disease. In following the question arose, if the case definitions used within the national and international organizations are an adequate tool for the clinical diagnosis of influenza in children as well as in adults. Therefore medical charts from 146 children and 229 adults were retrospectively analyzed. In addition, the initial viral loads of all 375 patients and the duration of virus shedding of a subset of 79 patients were also investigated. Children show a wider clinical spectrum including gastro enteric symptoms and also a different spectrum of laboratory parameters like elevated CRP-levels, leucocytosis, and higher viral loads. Further, children show significantly more often complications, for example, myositis that may be underdiagnosed. In patients receiving antiviral-therapy complications occurred significantly less often and the presence of symptoms was significantly shorter compared to the untreated group (2.3 days vs. 6.0 days). In summary, the differences in the clinical picture between children and adults should be taken into consideration for the clinical diagnosis of influenza and also for a future discussion on age specific influenza case definitions. J. Med. Virol. 86:1048-1055, 2014. © 2014 Wiley Periodicals, Inc.
- Journal of medical virology.J Med Virol.2014 Jun;86(6):1048-55. doi: 10.1002/jmv.23912. Epub 2014 Feb 24.
- During the influenza pandemic 2009 children and adults differed in the clinical course of the influenza disease. In following the question arose, if the case definitions used within the national and international organizations are an adequate tool for the clinical diagnosis of influenza in children
- PMID 24615722
- Altered RIG-I/DDX58-mediated innate immunity in dermatomyositis.
- Suárez-Calvet X1, Gallardo E, Nogales-Gadea G, Querol L, Navas M, Diaz-Manera J, Rojas-Garcia R, Illa I.Author information 1Neuromuscular Diseases Unit, Neurology Department, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona and Institut de Recerca Sant Pau, Barcelona; Centro Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.AbstractWe investigated the molecular mechanisms involved in the pathogenesis of three inflammatory myopathies, dermatomyositis (DM), polymyositis (PM) and inclusion body myositis (IBM). We performed microarray experiments using microdissected pathological muscle fibers from 15 patients with these disorders and 5 controls. Differentially expressed candidate genes were validated by immunohistochemistry on muscle biopsies, and the altered pathways were analysed in human myotube cultures. Upregulation of genes involved in viral and nucleic acid recognition were found in the three myopathies but not in controls. In DM, retinoic acid-inducible gene 1 (RIG-I, DDX58) and the novel antiviral factor DDX60, that promotes RIG-I-mediated signaling, were significantly upregulated, followed by IFIH1 (MDA5) and TLR3. Immunohistochemistry confirmed overexpression of RIG-I in pathological muscle fibers in 5/5 DM, 0/5 PM, and 0/5 IBM patients, and in 0/5 controls. Stimulation of human myotubes with a ligand of RIG-I produced a significant secretion of interferon β (p<0.05) and upregulation of Class I MHC, RIG-I and TLR3 (p<0.05) by interferon β-dependent and TLR3-independent mechanisms. RIG-I-mediated innate immunity, triggered by a viral or damage signal, plays a significant role in the pathogenesis of DM but not in that of PM or IBM.
- The Journal of pathology.J Pathol.2014 Mar 6. doi: 10.1002/path.4346. [Epub ahead of print]
- We investigated the molecular mechanisms involved in the pathogenesis of three inflammatory myopathies, dermatomyositis (DM), polymyositis (PM) and inclusion body myositis (IBM). We performed microarray experiments using microdissected pathological muscle fibers from 15 patients with these disorders
- PMID 24604766
- Infection of myofibers contributes to increased pathogenicity during infection with an epidemic strain of chikungunya virus.
- Rohatgi A1, Corbo JC, Monte K, Higgs S, Vanlandingham DL, Kardon G, Lenschow DJ.Author information 1Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.AbstractChikungunya virus (CHIKV) is an alphavirus transmitted by mosquitoes that is known to cause severe arthritis and myositis in affected patients. The ongoing epidemic began in eastern Africa in 2004 and then spread to islands of the Indian Ocean, India, and Southeast Asia, ultimately afflicting millions. During this outbreak, more severe disease manifestations, including fatalities, have been documented. The reasons for this change in pathogenesis are multifactorial but likely include mutations that have arisen in the viral genome which could alter disease pathogenesis. To test this hypothesis, we used a murine model of CHIKV to compare the disease pathogeneses of two recombinant strains of CHIKV, the first derived from the La Reunion outbreak in 2006 (LR2006 OPY1) and the second isolated from Senegal in 1983 (37997). While the two strains exhibited similar growth in mammalian cells in vitro, we observed more severe clinical disease and pathology in mice infected with the LR2006 OPY1 strain of CHIKV, which included prolonged viremia and elevated viral titers and persistence in the muscle, resulting in devastating myonecrosis. Both CHIKV strains infected connective tissue fibroblasts of the muscle, but only the LR2006 OPY1 strain replicated within myofibers in vivo, despite similar growth of the two strains in these cell types in vitro. However, when the 37997 strain was administered directly into muscle, myofiber infection was comparable to that in LR2006 OPY1-infected mice. These results indicate that differences in the ability of the strain of CHIKV to establish infection in myofibers may contribute to the increased disease severity. Importance: CHIKV is an emerging pathogen that causes significant morbidity. Little is known about the pathogenesis of the disease, and this study suggests that the ability of a recent epidemic strain to infect myofibers results in increased disease severity. Better understanding of how CHIKV causes disease contributes to the ultimate goal of creating therapeutics to alleviate the impact of this debilitating virus.
- Journal of virology.J Virol.2014 Mar;88(5):2414-25. doi: 10.1128/JVI.02716-13. Epub 2013 Dec 11.
- Chikungunya virus (CHIKV) is an alphavirus transmitted by mosquitoes that is known to cause severe arthritis and myositis in affected patients. The ongoing epidemic began in eastern Africa in 2004 and then spread to islands of the Indian Ocean, India, and Southeast Asia, ultimately afflicting millio
- PMID 24335291
Japanese Journal
- Hepatitis C Virus (HCV) Reactivation Caused by Steroid Therapy for Dermatomyositis
- Mori Nami,Imamura Michio,Takaki Shintaro,Araki Takehisa,Hayes Nelson C.,Aisaka Yasuyuki,Chayama Kazuaki
- Internal Medicine 53(23), 2689-2693, 2014
- … however, the serum alanine aminotransferase levels rapidly increased, with positive serum HCV RNA and a high viral titer. … Liver enzymes and the viral load should be monitored in anti-HCV-positive patients receiving immunosuppressives, even if serum HCV RNA is negative. …
- NAID 130004713280
- Drug-induced Hypersensitivity Syndrome Associated with a Marked Increase in Anti-paramyxovirus Antibody Titers in a Scleroderma Patient
- Naniwa Taio,Maeda Shinji,Sawada Hiroo,Watanabe Yuko,Osawa Tomoyo,Hayami Yoshihito,Banno Shogo,Morita Akimichi,Ueda Ryuzo
- Allergology International 56(3), 303-308, 2007
- … A 61-year-old man with early diffuse cutaneous scleroderma with myositis and progressive interstitial pneumonia developed generalized erythema with high fever 3 weeks after taking sulfamethoxazole/trimethoprim. … Discussion: These findings suggest that paramyxovirus infection had contributed to the development of DIHS in this patient and that there is a need to seek evidence of other viral infections in some cases of DIHS, especially those without herpes virus reactivation/infection. …
- NAID 130004476931
- Ｒｅｓｐｉｒａｔｏｒｙ ｓｙｎｃｙｔｉｕｍウイルス感染を契機に発症した多発筋炎の１乳児例
- 長澤 哲郎,佐久間 啓,荒木 聡,渡辺 章充,牧野 道子,埜中 征哉
- 脳と発達 32(6), 543-546, 2000
- ウイルス (RSV; respiratory syncytium virus) による間質性肺炎にて入院後, 筋力低下をきたし筋生検にて多発筋炎と診断された11カ月の乳児例を報告した.ステロイドパルス療法が著効し, 人工呼吸管理から離脱, 歩行可能となった.その後の発育, 発達は良好に経過しており, ステロイド中止後も再発の徴候は見られない.ウイルス感染と多発筋炎の関係についての報告は散見されるが …
- NAID 130004183430
Related Links
- The clinical spectrum of muscle syndromes associated with viral infections ranges from benign, commonly experienced myalgias to rhabdomyolysis with myoglobinuric renal failure.This topic will review the clinical, pathologic, and ...
- Infectious myositis may be caused by a broad range of bacterial, fungal, parasitic, and viral agents. Infectious myositis is overall uncommon given the relative resistance of the musculature to infection. For example, inciting events ...
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- 関
- virally、virogenic、virus