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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/06/14 12:41:41」(JST)

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Vindesine is an anti-mitotic vinca alkaloid used in chemotherapy. It is used to treat many different types of cancer, including leukaemia, lymphoma, melanoma, breast cancer, and lung cancer.^[1]

References

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1. 成人T細胞性白血病/リンパ腫の治療および予後 treatment and prognosis of adult t cell leukemia lymphoma
2. マイトマイシン-Cの肺毒性 mitomycin c pulmonary toxicity
3. 治療関連骨髄腫瘍：急性骨髄性白血病および骨髄異形成症候群 therapy related myeloid neoplasms acute myeloid leukemia and myelodysplastic syndrome
4. ステージIII非小細胞肺癌のマネージメント management of stage iii non small cell lung cancer
5. 限局進行性で切除不能の転移性食道癌および胃癌に対する全身療法 systemic therapy for locally advanced unresectable and metastatic esophageal and gastric cancer

English Journal

Differential involvement of glutathione S-transferase mu 1 and multidrug resistance protein 1 in melanoma acquired resistance to vinca alkaloids.

Attaoua C1, Vincent LA, Abdel Jaoued A, Hadj-Kaddour K, Baï Q, De Vos J, Vian L, Cuq P.
Fundamental & clinical pharmacology.Fundam Clin Pharmacol.2015 Feb;29(1):62-71. doi: 10.1111/fcp.12093. Epub 2014 Dec 3.
On account of its extreme intrinsic resistance to apoptosis and of its strong ability to become chemoresistant after a primary response to drugs, malignant melanoma (MM) is still a therapeutic challenge. We previously showed that glutathione S-transferase mu 1 (GSTM1) acts in synergy with multidrug
PMID 25283245

Lysosomes and unfolded protein response, determinants of differential resistance of melanoma cells to vinca-alkaloids.

Vincent LA1, Attaoua C, Bellis M, Rozkydalova L, Hadj-Kaddour K, Vian L, Cuq P.
Fundamental & clinical pharmacology.Fundam Clin Pharmacol.2015 Jan 20. doi: 10.1111/fcp.12098. [Epub ahead of print]
On account of its strong ability to become chemoresistant after a primary response to drugs, malignant melanoma (MM) remains a therapeutic challenge. The present study focuses on acquired resistance to vinca-alkaloids (VAs) by using VA-resistant MM cell lines (CAL1R-VCR, CAL1R-VDS and CAL1R-VRB), es
PMID 25601431

Solitary plasmacytoma of the sternum with a spiculated periosteal reaction: A case report.

Zhao J1, Li Y1, Wu W1, Zhang Z1, Ding Y1.
Oncology letters.Oncol Lett.2015 Jan;9(1):191-194. Epub 2014 Oct 24.
Solitary plasmacytomas (SPs) represent ≤5% of all plasma cell neoplasms and mostly occur in the spine, pelvis, ribs and pectoral girdle, while rarely occurring in the sternum. The tumors typically appear as osteolytic lesions. In rare cases, SPs can manifest as bony spicules on the surface of the
PMID 25435957

Japanese Journal

肺扁平上皮癌に対する放射線治療8年後，照射野内に発生した肺小細胞癌の1例

田中真,上野剛,末久弘,澤田茂樹,原田大二郎,山下素弘
肺癌 55(1), 9-13, 2015
… 背景．放射線治療後の長期生存例では放射線誘発癌が問題となることがある．症例．67歳，男性．健診で胸部異常陰影を指摘された．精査で右上葉の肺扁平上皮癌（cT2aN2M0，stage IIIA）と診断し，mitomycin＋vindesine＋cisplatin（MMC＋VDS＋CDDP）による化学療法2コースと60 Gyの同時性放射線療法を施行した．治療の結果complete response（CR）であり，以後再燃なく経過観察されていた．8年後のCT検査で放射線治療後器質化肺内に，腫 …
NAID 130005062360

Treatment outcome of elderly patients with aggressive adult T cell leukemia-lymphoma: Nagasaki University Hospital experience

Makiyama Junya,Imaizumi Yoshitaka,Tsushima Hideki,Taniguchi Hiroaki,Moriwaki Yuji,Sawayama Yasushi,Imanishi Daisuke,Taguchi Jun,Hata Tomoko,Tsukasaki Kunihiro,Miyazaki Yasushi
International Journal of Hematology 100(5), 464-472, 2014-11
… VCAP (vincristine, cyclophosphamide, doxorubicin, and prednisone)-AMP (doxorubicin, ranimustine, and prednisone)-VECP (vindesine, etoposide, carboplatin, and prednisone) is a standard regimen for aggressive adult T cell leukemia-lymphoma (ATL). …
NAID 120005527922

Membranoproliferative Glomerulonephritis in Castleman's Disease: A Systematic Review of the Literature and 2 Case Reports

, , , ,
Internal Medicine 51(12), 1537-1542, 2012
… Both cases were sensitive to chemotherapy with cyclophosphamide, vindesine and prednisone (COP). …
NAID 130002062150

Related Pictures

★リンクテーブル★

リンク元	「ビンカアルカロイド」
拡張検索	「vindesine sulfate」

「ビンカアルカロイド」

Vindesine
Systematic (IUPAC) name
	methyl (5S,7S,9S)- 9-[(2β,3β,4β,5α,12β,19α)- 3-(aminocarbonyl)- 3,4-dihydroxy- 16-methoxy- 1-methyl- 6,7-didehydroaspidospermidin- 15-yl]- 5-ethyl- 5-hydroxy- 1,4,5,6,7,8,9,10-octahydro- 2H- 3,7-methanoazacycloundecino[5,4-b]indole- 9-carboxylate
Clinical data
AHFS/Drugs.com	Micromedex Detailed Consumer Information
Pregnancy cat.	D (AU)
Legal status	℞ Prescription only
Routes	Intravenous
Pharmacokinetic data
Protein binding	65-75%
Metabolism	Hepatic (CYP3A4-mediated)
Half-life	24 hours
Excretion	Biliary and renal
Identifiers
CAS number	59917-39-4
ATC code	L01CA03
PubChem	CID 40839
DrugBank	DB00309
ChemSpider	37302
UNII	RSA8KO39WH
KEGG	D01769
ChEBI	CHEBI:36373
ChEMBL	CHEMBL219146
Chemical data
Formula	C43H55N5O7
Mol. mass	753.926 g/mol
SMILES	eMolecules & PubChem
	InChI InChI=1S/C43H55N5O7/c1-6-39(52)21-25-22-42(38(51)55-5,33-27(13-17-47(23-25)24-39)26-11-8-9-12-30(26)45-33)29-19-28-31(20-32(29)54-4)46(3)35-41(28)15-18-48-16-10-14-40(7-2,34(41)48)36(49)43(35,53)37(44)50/h8-12,14,19-20,25,34-36,45,49,52-53H,6-7,13,15-18,21-24H2,1-5H3,(H2,44,50)/t25-,34+,35-,36-,39+,40-,41-,42+,43+/m1/s1 ; Key:HHJUWIANJFBDHT-KOTLKJBCSA-N ;
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